Basic Information

Gene Symbol
-
Assembly
GCA_947363905.1
Location
OX376212.1:1585544-1588577[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 4.3 3.2e+02 2.6 0.1 1 21 171 191 171 192 0.93
2 17 0.00062 0.046 14.6 5.4 1 23 198 220 198 220 0.98
3 17 1.7 1.2e+02 3.8 0.5 2 23 224 245 223 245 0.94
4 17 0.0011 0.084 13.8 0.1 2 23 331 353 330 353 0.96
5 17 9.1e-05 0.0068 17.3 0.8 1 23 359 382 359 382 0.97
6 17 2.5 1.8e+02 3.3 0.7 1 20 386 405 386 407 0.92
7 17 0.00014 0.011 16.7 0.2 1 23 415 438 415 438 0.96
8 17 0.9 67 4.7 1.0 1 23 443 466 443 466 0.85
9 17 7.9e-05 0.0059 17.5 0.3 2 23 479 500 478 500 0.97
10 17 0.0076 0.56 11.2 1.6 1 23 506 528 506 528 0.98
11 17 0.35 26 6.0 2.4 2 23 534 554 534 554 0.96
12 17 0.00029 0.022 15.7 1.0 2 23 560 581 560 581 0.97
13 17 0.041 3.1 8.9 0.1 2 23 586 606 585 606 0.95
14 17 2.6e-05 0.002 19.0 3.1 1 23 653 675 653 675 0.98
15 17 0.0011 0.083 13.8 1.4 2 23 681 702 680 702 0.96
16 17 0.048 3.6 8.7 0.8 1 23 708 731 708 731 0.93
17 17 0.042 3.2 8.9 0.3 1 23 736 759 736 759 0.96

Sequence Information

Coding Sequence
ATGGACATTTTCAAGTTGAAGCTCAAAAATGTCCTTCACAGTACAAAGTATTGTGGGATATGCTTGGAAATTGACGATAATATGAGCACTATTAAGGAAAATCTGGAGATCATTGTGAATGAACGGACTAGCACGAAAGCTTTGAAGGCTATAATTGATATAGTGTTTAAAGAGACTAAATATACCCCAGCAAGTTCACTCATATGCAACAGTTGTGTGGAAAAACTGATTCAGTCATACATTTTCATAGAAAATGCGAAGGAAACATCCAATATTTTAAATAACTATATTGATGACTTGTTTAGCAAGTCAGATGATATTTTCAAACATTTGCCGGAGTCAAGCAATGAAAGTACAAATGTTGTTATTGTATTAGAAAATAATATCCATGATTCTCCTGAAAAAAAGTCAAGAAAAGATGAGTTTAACATAATGGCAGAAAAACACAACGAAACCTTTGAAGTGAAAAAGGAATTTAAACCAAATACATACTCTCAAAAAAGAAAGAAATTCCAATGTGTGAAATGTCTGGTAATACTACCCTCACTCAGAGCGTTAAAGATTCATAGAATGAAATGTAGGAAGCAGATATTTCGGTGTAGACTATGTTTTAAGACATTTATAAATAAACAACATTTAAATATCCATTACAAACTGCATTTGAAAGTGAAATGCAAATTTTGTCCTGAAATACTTCTTAAAAAGGAATTACTGGACCATCTTAAAACTAACCATGGTGATTCTTTACTCAAATGTTTGAAATGTGAACTATTTTACTCTTTAATAACATTTCAAACTCACACTAAAGTCTGCCAACAAATAAAAGAAGAAAAACCTCAATGTCTGATGTGCCTAAAAACCTATAATGAAAAAGAATTCAAGTCCCATAAATGCAAGTACAGCTGCCCAGAATGTACTGAAATACCTTGCATGCATTATAAGTATTTGAAGTATTATAGGGAACAGACATTAAACAACGCAGACAAGATCAAATGTGTTGACTGCGACTATGTTAGTACAAGAAAAGAGAATTTACTTGGACATGTGAATAAGGTCCATTTAAACAATCATCCATATACTTGTGATAAATGCGGACAACAGTTTTATTCAAAAGTAGTTTTAAAAGCTCATATTCTTCGGTTCCATGAAAACTGTTTTGTGTGCCAGTGCTGTGATTCAGAATTTAGTAATATTAAAAATTACGAAAGTCATGTCATATCCTGTGAAGATATCAAAAGAAAGTTTGCTTGTGACAATTGTCCAGCCTCTTTTGATTTGTCTGAGAATTTGACGAACCATATAAAACGGAGACATAGCACAGATATCTTCCCCTGTGGCCTTTGCAATAAAAAGTTCCTGAAAGATTCTAAACGGAAAGAGCATATGGTTAAAGTGCATAGCATTCTCAAACTTAAGAAAAGGGATAAAAATGTAGAATGTCTTGTGTGTCAAGAAAAGTTTGATAATAAAGGACAGTTGGTGCAGCATATGAAATCTCATGGTCCGCATACTACATACCCATGCAGGATATGCAATACAGAGTATCAGACTCTGAGACAGTTTCGGGCACATAATCGCAAGCACAACGGACCATTTGCTACATGCCATGTTTGTGGTAAGCAAATGAGAGAAATCCTACTAAAAAAACATCTGACTACCCACTCAGATGCTGTAGAAACCTGTGAGACTTGTGGCAGGTCTTTTCAAAACATCACTCTACTAAAATACCACCAGAAAGTTCATTTAGAAAGTGTCCCATGTCCTAAATGTAAGAAAATGATCAACCCGGCCAGACTGCGGCGGCATTGGAGAGGGCATCTAATGGAAGAGAATCCTGCTCAAAAAGAAATGCGGAAACAACGGCCAAACTTGAAATGTGAACAGTGTGAATATAAGACATGGAACAACACACTTTTAGAATGTCATATGAACCGCCATCATTTGAAAATAAAGCCATACGTCTGCCATATATGCAGCAAAGACTTCATAGGAAAACATTTGCTGAAAAAGCATATTGAAACGCATGATATGAAAAGCGTTGTCTGCATGGTGTGCCTGAAGAGTTTTGCCAACTCGACTTGCTTGAAAATGCATTTGCGTCTACATACAGGTGAAAAGCCTTTTACTTGTGAAATATGTGGGGACCGATTTCGTTCATCAAGCATTATGAACGTACACAAGTTAAAAAAGCATTCTGGCAAGAGTTATATGTGTCCGTTATGTTCAAATAAATTTTATATTGTAAGGGATTTACGAAGACATGTGATTAAAGTGCATTGGAAGCAGAAAAATAAAAGGTTTGACCCTCGAGAGTTGAAAGGGCTAGATAAAGAACATTATCATTTGTTTCAGGATGGCAGGAGAGTTAAAGTTGCCGACGAAGATGTCGATTTTTATATGCCTCGTTGA
Protein Sequence
MDIFKLKLKNVLHSTKYCGICLEIDDNMSTIKENLEIIVNERTSTKALKAIIDIVFKETKYTPASSLICNSCVEKLIQSYIFIENAKETSNILNNYIDDLFSKSDDIFKHLPESSNESTNVVIVLENNIHDSPEKKSRKDEFNIMAEKHNETFEVKKEFKPNTYSQKRKKFQCVKCLVILPSLRALKIHRMKCRKQIFRCRLCFKTFINKQHLNIHYKLHLKVKCKFCPEILLKKELLDHLKTNHGDSLLKCLKCELFYSLITFQTHTKVCQQIKEEKPQCLMCLKTYNEKEFKSHKCKYSCPECTEIPCMHYKYLKYYREQTLNNADKIKCVDCDYVSTRKENLLGHVNKVHLNNHPYTCDKCGQQFYSKVVLKAHILRFHENCFVCQCCDSEFSNIKNYESHVISCEDIKRKFACDNCPASFDLSENLTNHIKRRHSTDIFPCGLCNKKFLKDSKRKEHMVKVHSILKLKKRDKNVECLVCQEKFDNKGQLVQHMKSHGPHTTYPCRICNTEYQTLRQFRAHNRKHNGPFATCHVCGKQMREILLKKHLTTHSDAVETCETCGRSFQNITLLKYHQKVHLESVPCPKCKKMINPARLRRHWRGHLMEENPAQKEMRKQRPNLKCEQCEYKTWNNTLLECHMNRHHLKIKPYVCHICSKDFIGKHLLKKHIETHDMKSVVCMVCLKSFANSTCLKMHLRLHTGEKPFTCEICGDRFRSSSIMNVHKLKKHSGKSYMCPLCSNKFYIVRDLRRHVIKVHWKQKNKRFDPRELKGLDKEHYHLFQDGRRVKVADEDVDFYMPR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01119684;
90% Identity
iTF_00037168;
80% Identity
-