Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.32 3e+03 -2.2 0.4 46 73 33 51 12 74 0.42

2 3 4.7e-16 4.4e-12 46.5 17.1 1 45 120 168 120 198 0.69

3 3 0.2 1.8e+03 -1.5 0.1 239 252 205 218 182 231 0.47

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.32	3e+03	-2.2	0.4	46	73	33	51	12	74	0.42
2	3	4.7e-16	4.4e-12	46.5	17.1	1	45	120	168	120	198	0.69
3	3	0.2	1.8e+03	-1.5	0.1	239	252	205	218	182	231	0.47

Coding Sequence: ATGCccaaggccaagaagaaaCCTTTAGGCGGATCAGCGGCCACGAAATCCACGACACCCGACAAATCCAAGGCTCTGAAAAGAAGCGCCAACCCAGAGAAAACCTCGAGATCACCGGCTGgcgaggcagcaacaacaacaaggcaaacaaacggcaGCGATGAAGTCATCGATCCGCAGGCCGCCGAGAAAGCTTTTAGCGCCGAACAGAAACCCCCAGAAATCGCACGGCCGCCGACTGGCAATGATAACGAACCTGCGAATGATAAAGATCAAGAATCGCTGGCGGACTTCGAAGAGGACCCGCCGGAGGAGCAGGAACTCCTGGTGCAGTTCCTGGGCGAGGCCAATCGCATTGCAGAAGCGCGACTGGAGGCCCGCCGTCGGGCCCGGGCCGAGGCGCGGGAGATCCGCATGCGCGAGCTGGAGCGCCAGCAGAAGGAGCAGGAGCAAACCCAGCGTCCCGACCGAAGCCGCAGACGATCTCGAAGCCGCAACGCCCCAATTTTGCATCCGGTGGCCGACTGCAACACTACTGAGGCGATCCTGAAGTCCCTTAACGATAGCATAAATTCATTGCGTTTGATCCAGGAAAAACAGATGGATCttatgatgatgatgctgaagcagcaacaacaacagacgcAGCAACAGGGGCAAAACCTGAATTTGCTCACTGCCCTCCAAGTGCAGCAAGCACCAAAATAA
Protein Sequence: MPKAKKKPLGGSAATKSTTPDKSKALKRSANPEKTSRSPAGEAATTTRQTNGSDEVIDPQAAEKAFSAEQKPPEIARPPTGNDNEPANDKDQESLADFEEDPPEEQELLVQFLGEANRIAEARLEARRRARAEAREIRMRELERQQKEQEQTQRPDRSRRRSRSRNAPILHPVADCNTTEAILKSLNDSINSLRLIQEKQMDLMMMMLKQQQQQTQQQGQNLNLLTALQVQQAPK

Sequence clustering based on sequence similarity using MMseqs2