Basic Information

Gene Symbol
E2F4
Assembly
GCA_030264695.1
Location
JARJDU010027901.1:1949-3022[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.9e-30 2e-26 91.7 0.1 2 64 10 73 9 74 0.98
2 2 1.2 8.1e+03 -3.1 0.0 16 36 117 137 114 138 0.71

Sequence Information

Coding Sequence
ATGTCTGATGTACCGTCGAGCCGTTTCGAGAAGTCCCTTGGCCTTCTCACTACGAAGTTCGTGAGCTTGCTTCAAAACTCCAATGGCGGGGTTCTAGATTTGAAAACGGCCGCTGATCAACTGGCCGTGCGACAAAAACGACGAATTTATGATATTACAAATGTGCTTGAAGGAATTGGACTCATCGagaaaaagagtaaaaatagTATACAATGGAAACCATACACCTACAAGGATTCGATCCAAAATACCTCCTCACAGGATATTGcatcaaaagtaaaaaaattaaaaactgacATATCTGCACTTGATACAGTAGAAAGTAATTTGGATCTGCATCTCTCTTGGTTAGAACAAAGTATAAAGAATGTAACAAATGATAAAGAAATTTGCCAAGATctgtatattaaaaaagatgACCTAAAGGCAATTGCCAATGAAGAAGATAGATTGATTTTGTTGCATATGCCAATTAATTCATCTGTGAAGGTTGATGATAGCTGCTCTATGGGCTATCGCATGAAAATCAGGACAAAAATTGGAACAATACAAGGATGTGTGAGTAAAGATGATTTAATGATTGAGGACCTTGCTGAAGATCCTAGTGAAAGTACTGATGTTGAAGCACCTCATAACAGCAAGcgaaaaagaattgaatttgaGGATGATGATATTGAAACTGCTGATATTCTGCTTAGGAATCCTTGTAAAAGTATTGAAAGGAACAAGTTTGTTCAACAAAattcaaaatttgtacCACTAAATGCATCATATTCAAAAGATTTCTCCTATGTGCTATCAGATATGGAAGGAGCAAGTGATCTATTTGATATTCCACCTAAAAGATTTATAGCGTAG
Protein Sequence
MSDVPSSRFEKSLGLLTTKFVSLLQNSNGGVLDLKTAADQLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKPYTYKDSIQNTSSQDIASKVKKLKTDISALDTVESNLDLHLSWLEQSIKNVTNDKEICQDLYIKKDDLKAIANEEDRLILLHMPINSSVKVDDSCSMGYRMKIRTKIGTIQGCVSKDDLMIEDLAEDPSESTDVEAPHNSKRKRIEFEDDDIETADILLRNPCKSIERNKFVQQNSKFVPLNASYSKDFSYVLSDMEGASDLFDIPPKRFIA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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