Basic Information

Gene Symbol
Mbd2
Assembly
GCA_030264535.1
Location
JARJEB010000543.1:3787-4708[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.3e-09 1.1e-05 25.3 0.2 3 59 10 88 8 106 0.81

Sequence Information

Coding Sequence
atgagTTTGAGCAATATAACAatcgaaaaaacaaaatacgaaTGCACAACATTACCAAAACGATGGCAAGGACAAGAACGTGAGTTATCGTTGAAAAAGACGGGCATCCAACTTGGCAAAGTCGACGTAATGTACTACAGTCGAAATGTACGCAACGATGCTTCCCTTGTTCCACCGATCCGCCAGACTGCATCGATCTTCAAACAACCGGTGACCGTCTACAAAACGCAGGAGAGTAAAGTCAAGACTGATTTCAAACACGGCATTCAAGAGAAACCGAAACAACTCATTTGGGAGAAACGTTTGGAAGGGCTGCGTGCATGCGATTTGGATGGTGTGCAATTCGAAGGTATGGTGCTACCGAAAGGATTGAAACCCGTCGGGCCGAACGTTACCGAAGAAAcgattatacagagtgttgcGACAGCTCTACACGTATCATCGCAACCAGTGACGGGACAAACAGGCAGTAGGACTTCATTGGAAAAGAATCCGGGTGTGTTTTTAGATCCGAAACAGCCGCTTGTTCAAGCCGTTAATATCGCTGAAGATGATATCAAAGTGCAGGAGGAACGCGTTGCGGCAGCACGAAGGCGACTGCAAGATGCTTTGATGGCGtag
Protein Sequence
MSLSNITIEKTKYECTTLPKRWQGQERELSLKKTGIQLGKVDVMYYSRNVRNDASLVPPIRQTASIFKQPVTVYKTQESKVKTDFKHGIQEKPKQLIWEKRLEGLRACDLDGVQFEGMVLPKGLKPVGPNVTEETIIQSVATALHVSSQPVTGQTGSRTSLEKNPGVFLDPKQPLVQAVNIAEDDIKVQEERVAAARRRLQDALMA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01351724;
90% Identity
-
80% Identity
-