Basic Information

Gene Symbol
su(Hw)
Assembly
GCA_963675445.1
Location
OY776277.1:3823711-3829592[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0018 0.22 13.3 2.3 1 20 132 151 132 153 0.94
2 12 7.2e-06 0.00085 20.9 0.4 3 23 204 225 202 225 0.93
3 12 0.03 3.5 9.5 0.1 1 23 231 253 231 253 0.95
4 12 2.4e-06 0.00029 22.4 2.1 1 21 260 280 260 281 0.95
5 12 2.2e-05 0.0027 19.3 1.3 3 23 294 314 292 314 0.96
6 12 1.8e-06 0.00021 22.8 3.4 1 23 325 347 325 347 0.98
7 12 7.3e-05 0.0086 17.7 0.8 1 23 353 375 353 375 0.97
8 12 1.6e-05 0.0018 19.8 1.0 1 23 381 403 381 403 0.99
9 12 1.1e-05 0.0013 20.3 1.4 1 23 409 431 409 431 0.97
10 12 2e-05 0.0024 19.4 1.5 1 23 435 457 435 457 0.98
11 12 0.0033 0.39 12.5 0.5 2 22 472 492 471 495 0.91
12 12 1.6 1.9e+02 4.0 0.2 3 23 510 531 508 531 0.93

Sequence Information

Coding Sequence
atgagttttaaaaaagaaccTAAAAGTACACAAACCAGACGTTCCAGTTTGggaatcaaaatactcaatGACGAAAAAGTGACTGCGCCGTTGCCTTTAACAATACCAGTTATGACCTCGGTGCCGTTGTCTCCACCGAAACAAATCACATTGTCCATTGCCAAACCCAAAAAAGAATTAAAGCAAAAGAATATGGATCATTATGTGATGAAAACGGTCAAAGGAGAGAAGAATACTGACAATGGCCTTGAAGAAAGTGAAACGATTGATTTTGTATTGACAGAAAATAATGATGACGAATCATTAAAACCGGGTGGAGAAATAACCGAAGAATTACATTTAAGTGAAGATGAGGATCATGAGCCCACCTTAACGAGCTCGGATCTCGTTGAGCATGTTTGTGGAAAATGCTTTACAACTTTTAGGCGCTTAAAgAGCTTAAAAAAACATTTGGACTATTGCCGTTTCGACAGCGGCTATAGCATTCGTAAAGCGGAAATGttgaaaaacttggaaaaaattgaaaagGACGCTATCATAATGGAAAATAaagatgtttgtttttgttgtggaGAAAGTTATGATACATTTCAtCTGGGACACATCAATTGTCCTGATTGTCCAAAATCTTTCAAAACTCAAATGAGCTATGAACGTCATATATTCATAACACATTCCGAAGATGATTTCTATCCTTGCAGTATTTGTAATGCTAAATTGCGTAGcgcaaatttgttaaaattgcaTGAAGAGCAACATCGTAATCGAGGAAAACCGTTTGCTTGTAAGATTTGTGGCAAAGACTTTACTCGCTCCTATCATTTGAGTCGTCATCAAAAGTATTCGTCCTGTTCGGCCAATGAAAATGATACTATGAATTGTAAGGTGTGTAATAGAGCGTTCTATCGTTTGGACAATTTGAGGCAACATCTTAAGCAACATTTAGGAActcagcaaacaaaaaaatcggaGTACATGTGTccaatatgtaaaaaatgtttctacAGTTTGTCAACATTAAAtatCCACACGCGTACACATACTGGAGAAAGACCATTTGATTGTGATTTATGTGAGAAAAAATTTCCATCACTAGTTGCTTTAAAAAAGCATAGACGTTATCATACAGGTGAAAAACCCTATACTTGTTCAGTGTGCAAGCAATCGTTTGCTGTTAAGGAAGTCTTAAATCGTCATATGAAACGACATACGGGCGAGAGACCTCATGTCTGCACTGAATGTGGCAAAAGTTTTATCCAAGGCACTCAACTTCGCACTCACGCAAAGACTCACTTAAGGCCATACGTATGCAATCAGTGCCCACAAAAGTTTAAAACTGAAAAGCAATTACTGAAGCACTTGAAAGAACACAGTACATTATTAAGGAGAAAGGGTCGCACACCAATGGCAAATAAGTGTGATATATGTAAAATCGGTTTCAAAACTGAAATACAGTTTAACGAACACATGCAGAATGGAAGACATATCAcACCTGCACAAAGACGGAGATTGAAAACTCGAACTGATTGTGCAGTTTGTAAAGAGAATTTTGAATCTGTACAAAGTCTTCAATTCCACATACTTAAAGTTCATCAAGAGGATCCTGAAACGTTCGTTAATGAGGACCACTTTGAAAGACCAATTCATACGGAGAACAATGATTCCATGTTAATGCCTACtccaaaagtaattaaaattgagGATTCACAAGGTGCACGCATAGAATTTGTTACCACTAACAGTGatggtaaaattttaaatacaaacgtCAAACATTTAAATCAGGAACAATCAGTTAGTCCTGAGAGCAAAGTTTCAGAAGCAAATAAAGTACACATTTTAGATCAGTTCATATTCGATGAGAGCCCTTCAACATCACTGAGTGCTGGCGGCAAACAGACTATATTTCTTTCAAACGAAGCTTATACTGTAATACCCTTAGAGTCGGATGGAGGTTTGATACAACCAATTACTACAACTATATTGCCAAATAATGTTGTAAGCCCAGAATGCAAAAAGGAACAACGCAAATCTTTAGCTGAAAGCTTGGCCGCTGCTATAGCAGACGATTCAGAGAATGTTTCCAATACCTTTGAATCGCCAGAATATTCTGAAGAAGAAGTCAAGATTAAAGATAATGTTAGCAAACTCTTAGACATGTTGGTAGACAGTTCAACACTTAAGAAATTTGGTTGGCCCAAAACTTCAGAAGAAAGTGTGCTTtgtaaagttattgaaaattgcgGTCATGATTTATCTAAAGAACAGTATAACTATGCCAGTTGGGATTACGCTAGCCGAATGCGTGAATatgttaaattactttttaccgTTGTCATTCACAACGACTCCATTAAAGAATTACTCAATAACTATCCCATTGACGAAGTTATTGAGTATGTTTTAGGAAATGACGAAGACGACGATGATGACGATGAGGACGACaatgcaaatgaaataaaagaaaatgataataagCCTTTGATGAAAACCATCAAATGTGAAAATGATgattaa
Protein Sequence
MSFKKEPKSTQTRRSSLGIKILNDEKVTAPLPLTIPVMTSVPLSPPKQITLSIAKPKKELKQKNMDHYVMKTVKGEKNTDNGLEESETIDFVLTENNDDESLKPGGEITEELHLSEDEDHEPTLTSSDLVEHVCGKCFTTFRRLKSLKKHLDYCRFDSGYSIRKAEMLKNLEKIEKDAIIMENKDVCFCCGESYDTFHLGHINCPDCPKSFKTQMSYERHIFITHSEDDFYPCSICNAKLRSANLLKLHEEQHRNRGKPFACKICGKDFTRSYHLSRHQKYSSCSANENDTMNCKVCNRAFYRLDNLRQHLKQHLGTQQTKKSEYMCPICKKCFYSLSTLNIHTRTHTGERPFDCDLCEKKFPSLVALKKHRRYHTGEKPYTCSVCKQSFAVKEVLNRHMKRHTGERPHVCTECGKSFIQGTQLRTHAKTHLRPYVCNQCPQKFKTEKQLLKHLKEHSTLLRRKGRTPMANKCDICKIGFKTEIQFNEHMQNGRHITPAQRRRLKTRTDCAVCKENFESVQSLQFHILKVHQEDPETFVNEDHFERPIHTENNDSMLMPTPKVIKIEDSQGARIEFVTTNSDGKILNTNVKHLNQEQSVSPESKVSEANKVHILDQFIFDESPSTSLSAGGKQTIFLSNEAYTVIPLESDGGLIQPITTTILPNNVVSPECKKEQRKSLAESLAAAIADDSENVSNTFESPEYSEEEVKIKDNVSKLLDMLVDSSTLKKFGWPKTSEESVLCKVIENCGHDLSKEQYNYASWDYASRMREYVKLLFTVVIHNDSIKELLNNYPIDEVIEYVLGNDEDDDDDDEDDNANEIKENDNKPLMKTIKCENDD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00045491;
90% Identity
iTF_00899905;
80% Identity
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