Basic Information

Insect: Linnaemya vulpina
Gene Symbol: MBD-R2
Assembly: GCA_963675445.1
Location: OY776277.1:96175102-96179887[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2 1.4e+04 -3.0 0.0 38 57 85 105 61 112 0.66

2 3 2.1e-22 1.5e-18 67.4 0.1 4 76 418 488 415 489 0.93

3 3 2.2 1.6e+04 -3.2 0.0 45 63 920 936 919 941 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2	1.4e+04	-3.0	0.0	38	57	85	105	61	112	0.66
2	3	2.1e-22	1.5e-18	67.4	0.1	4	76	418	488	415	489	0.93
3	3	2.2	1.6e+04	-3.2	0.0	45	63	920	936	919	941	0.79

Sequence Information

Coding Sequence: atgggTCGCCGGTGCTGTATAACCGGTTGTACATCGACTTCACGCTTACCAGAGCATCATGGCGTTACGTATCATTCCTTTCCCTCTGACCAGGCTGCACGTACCATTTGGATACGAAATACTAAAATAAGTGTTGATCGCCATATAACGAAAAGCGTTTTGGTATGCTCCAGACACTTTCGCCGCGCTGACTTTCAGCCACAACGAAGCGGTAAATATATGCTGAAGCAAAAGGTATTTCCAACAGTATTTCCTTGGGGTAAGATAGATGCTGCACAAATTGAAGAAGACTTGGAATATTTAAATTCTACTAGCGCAGCAACTCCTAGTAATATGTTGACAGCTTCGACCGCAGTAGATGAGGATACTAAAGCTACTGTGGCAGCAACAGTAGCACAAATAATGGCACAAACTGCAGAATTAAATGCAGCAGCAGGTATAAAAGTGGAAAAATCGGATGGTACTGTTGAAGAATTATTGAATGATAGTGCAGCAGCCATTCCATCCACACCTCAAAATGTTAAATTTGAACCAGTTACTTCCTTTAATCCTGGCGCCCGTTTGGAGGCACAGGATTTTGATGGTGTCTGGCATATAGCTCGTATCGTTGAAGTAGATAACGATGACCGCGAGGTTCTTATTAAATTCGAAaagaattctaaaaataaatcgaaCATTGCCGGTACTGAAGAATGGATACCTATGAATTCTACACGTCTGCGTCAACGTATttcaactaaaactattttgaacTTTGAGTTGGAGGAAAAATGTTTAGCACGTTGGTCGGGACCTCGCAAATTTCCCGGTACTGTTAAGAAAATACTACCAAATGATGTTTACGAAATTTTGTTCGATGATGgctatattaaaaatgttcgcGCTATTCATATGAATAAAGTGCATTCAAAGACTGTTGTGGAACCAGACGTTGTTGAGACTGTATCGTCAGAAATATCTGCTGTTGATCCTAATATTGACGACCAAAACGTTGTGAATCTGCCCACTACAAGTGTTGCATCAGCTGTAAAAAGACCATCATCTGGACAGAATTCTGGACCGTTGGCCAAAAAACGATCCTCTAACAGTTCTAGAAAGGATTGGCCATTATTGGACTTGTCAAAATTGGATTTAGCATCACTCAATCTCCCTGATATCCCCAAAGATGGCGAGTGGACTTGCCATTGGGTTAATGATCAACCGATAGGGCGTGAAGGTTACTTAGTTGTTGGCGAACATCGTAAACCTACAGTAATAGTAGAAGATTGGCGTCTACCTCCCGGTTGGATCAAACACATGTACCAACGATCCAATGTTTTAGGAAAATGGGATGTTATATTAGTTACGCCTAATGGCAAACGTTTTAGATCCAAAGCAGACCTTAAAACCTATTTGGAAGAACTAGGTCAGGTATACAACCCTGATATTTATGACTTCAGCATACACAGGCGGAGAGCAAAAGATATTAACTGCTATGTACATACCTCCGACTATGTGCCACAGCAGCCTCCGAAAGCGAAGACGTCATTAAATACTTCCCTAGATACCAGTATGGAAGACAAATCTTCGTCTATTGTGGAAACATTACCCAATGCTGTGGGTTCACCATATATGGATACACCTGTAGCGGAAGCGTTGCCTCCAATAGAATTGCTAACTTCTTCCACAAGTCTGGCGGCAGAGGATAAAAGTGTGACACAAGTAGAGGCAGAAGTTCCAAAACAGCTTTTAGAATCAGCTGAAGTTAGTTCGACCCCTACTCCTACATCTACACCTACTGTTGGTTTGAAGGAAGAGGCTGTATTATCGTCAGATTGTGCAACGCCTACTCCAGTTTCTAACGCAACATCAGCTTTTGAAGAATCACAAAAGGTCGACGATGGTTTTGCTCTTATTGGTGGCCTAAAGGTACAAATTATCGATAATCTATTTCGTTGTCCCCAGGAGGGGTGTACGAAAAATTTCCGGAAAgaaaatcatttgcaaattcATGTTAAACATTATCATCGCAATTTAGTAAAATTACTAGGATCCTGCCCTAAAATGTTAGAGTTGGCCGAAAAGCGAACTCATCCCGGTAGCAATGAAGCTGCTGAACCGGTGCCGAAAAATCAAATCCCTAATCaacaattttttgcaaaattgcatCAGCAAGACCTTGAACAAACCAGAGGTCATCGTAGAAGCACTGGTATTTTAAAGTCCACCGTTGATACGCCACCAGCAGAATTCAAAACAGAAAAAACAGACGAAGCTAATATAAAAGTCGAGGAAAATCTACAAAACATGGACAACTCACAAAATGATAATTCTCTAAATAATACAACTACTAGTGGGCTTATTGATAGTTCTTTTGCCTCTACTAGTGCAGCGGAAGATTCAATAAATGCAGAAACTGCTTTGACAGAACCTCCGGCAAGTAAGAGATCTAGATTTACTCCTAACAAGAAGACATCCGGCTCTAGAAAGAGTAATCGCCAAAGAACTACAAGAAAATATCTAACGGCAGCCCAGGCTACCGCTGGAGTAGGAACCGCTTCATCTTCATTGCCAGCAGCTTCGGAAACTAGCTTTATTGGAGTGGCGGAATTCGAAGAAACACGTCACTCGTTCAACGCAACaccagaaataaataaagatagtAAAAAACGTAAAACTATTTTACCCTCCAACACTCCTCTCAGCAGTGCTGATTCTCCCATAACGGCTGATTCCGGTTCGAACTCTTTCCAACCCCAAAATTCCACAGAAAACGATACAATTAATCAACCTCCACAGTATATCAAAGAAAACggtgaattaattaaaattgtgcaCATGCGCCAAGAAGAAATTATTAACTGTTTGTGTGGCTACTGCGAAGAAGATGGTTTAATGCTACAATGTGAGCTTTGCCTCTGTTGGCAGCATGGCTTATGTAATGGCATCGACAAAGTTTCGGATGTTCCCGACAAATATGTCTGCTATATATGTCGTAATCCACAAAGAGTTCGCGAATCTTTGCGCTTCAAACATGATCAAGACTGGTTATATGAAGGTAAATTACCAGTTGCAAACTACCACGCTTCCAACTCTATTCAGTTACAAAAAAGATCTGAATATCTTAAGCGTTCCCATGTTCTAACTGGCAATCTTTTGGAATTGAAAAACTACGTGCACTCCTTAAGAGTTAAAATTAATATAGCTGGTAATAAATGTCATCCCAAACTGTATCTTTGGGCTAAGAAATGGGATGAAGATGTAACAACcgatattaaaaaggaaattaaaccCGAAAGTGGTGAGGAAAATAAAAGAGTCAACGTTGACTCACCTATAACAcccacaaagaaaattaaatctgAACCCACTACTCCAGCGAGGCCTGTGCCAAATGTACCACAGCCAGAAGCTCCAATTGATCCCGTAGAATGCCAACAGCGTCTAATGGAGCACATTAATATTCAACAGGACTTAGTAATGAAACGCTTAAATGATATAGAATCGGCTATAGAtgttttggaaAATGAGGATGACTTGCCTGATTTGCGTGAAGAAGATTTCGGTGCCACTAAAGATGTTTTAGCCGCTTTTATTAAAGAACtagatattgtaaaaaaaattgcaaagttAAATAGTTTGGAACATACTAAGCTGGCACATAAAAACGCTACTACATTGAAATAG
Protein Sequence: MGRRCCITGCTSTSRLPEHHGVTYHSFPSDQAARTIWIRNTKISVDRHITKSVLVCSRHFRRADFQPQRSGKYMLKQKVFPTVFPWGKIDAAQIEEDLEYLNSTSAATPSNMLTASTAVDEDTKATVAATVAQIMAQTAELNAAAGIKVEKSDGTVEELLNDSAAAIPSTPQNVKFEPVTSFNPGARLEAQDFDGVWHIARIVEVDNDDREVLIKFEKNSKNKSNIAGTEEWIPMNSTRLRQRISTKTILNFELEEKCLARWSGPRKFPGTVKKILPNDVYEILFDDGYIKNVRAIHMNKVHSKTVVEPDVVETVSSEISAVDPNIDDQNVVNLPTTSVASAVKRPSSGQNSGPLAKKRSSNSSRKDWPLLDLSKLDLASLNLPDIPKDGEWTCHWVNDQPIGREGYLVVGEHRKPTVIVEDWRLPPGWIKHMYQRSNVLGKWDVILVTPNGKRFRSKADLKTYLEELGQVYNPDIYDFSIHRRRAKDINCYVHTSDYVPQQPPKAKTSLNTSLDTSMEDKSSSIVETLPNAVGSPYMDTPVAEALPPIELLTSSTSLAAEDKSVTQVEAEVPKQLLESAEVSSTPTPTSTPTVGLKEEAVLSSDCATPTPVSNATSAFEESQKVDDGFALIGGLKVQIIDNLFRCPQEGCTKNFRKENHLQIHVKHYHRNLVKLLGSCPKMLELAEKRTHPGSNEAAEPVPKNQIPNQQFFAKLHQQDLEQTRGHRRSTGILKSTVDTPPAEFKTEKTDEANIKVEENLQNMDNSQNDNSLNNTTTSGLIDSSFASTSAAEDSINAETALTEPPASKRSRFTPNKKTSGSRKSNRQRTTRKYLTAAQATAGVGTASSSLPAASETSFIGVAEFEETRHSFNATPEINKDSKKRKTILPSNTPLSSADSPITADSGSNSFQPQNSTENDTINQPPQYIKENGELIKIVHMRQEEIINCLCGYCEEDGLMLQCELCLCWQHGLCNGIDKVSDVPDKYVCYICRNPQRVRESLRFKHDQDWLYEGKLPVANYHASNSIQLQKRSEYLKRSHVLTGNLLELKNYVHSLRVKINIAGNKCHPKLYLWAKKWDEDVTTDIKKEIKPESGEENKRVNVDSPITPTKKIKSEPTTPARPVPNVPQPEAPIDPVECQQRLMEHINIQQDLVMKRLNDIESAIDVLENEDDLPDLREEDFGATKDVLAAFIKELDIVKKIAKLNSLEHTKLAHKNATTLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01174299;
90% Identity: iTF_00899576;
80% Identity: iTF_00900633;