Lhum001026.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Linepithema humile
Gene Symbol
croc
Assembly
GCA_000217595.1
Location
NW:1683083-1689273[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.5e-43 1.9e-40 136.1 0.1 2 87 70 154 69 155 0.97

Sequence Information

Coding Sequence
ATGCACACGCTATTCGGCGAACAGAACGCGTACTATCGGCACGCGACGGCGGTGCCGGTTGGTATGGGTACGCCGTCGTACCCGGGGGTGGGCGCCGCCCCAGGTTATTACGAACAGTATCGCTACGGCGGTTACGCGACGGCCGCCGGTTACCCAGTGTCGGGTATCGGCCAGCAGCACATTCATCACGCCGGCAAGGACATGGTAAAACCGCCGTACTCGTACATCGCACTGATCGCCATGGCTATTCAGAACGCGCCCGACAAGAAAATCACGCTCAACGGCATCTATCAGTTCATCATGGACCGCTTTCCGTATTATCGCGAGAACAAGCAGGGCTGGCAGAATTCTATCCGACACAATCTCAGTCTGAACGAGTGCTTCGTCAAGGTGCCGCGTGACGACAAGAAGCCCGGTAAGGGCAGCTACTGGTCCCTCGATCCCGACAGTTACAACATGTTCGACAACGGCTCTTATCTGAGACGCCGCAGACGCTTCAAGAAGAAGGACGCGCTGAAGGAGAAAGAAGAGGCGATGAAGCGGCAGGGTCTGGTGCCGGAGAAGCGTCAGGAGGACGCCAAGTCCGGCAGCAGCCAGGTCGCTCTACCGCCGCCGTCGGACACGTCGGCGAAGAAGCTCGGCACACTGGAGACCGCCACCGGTCTGTGCAAGCCGAAGCGCGAGCCGGTCAACGATCACACCAGCGGTAACCACTGCATGGCGGTTCAGGCGACTAAGTACAGCCTGCACAGCCCGATACAGgagacgaagacgacgacggcggTTGCGGCGCCCGGCCAGAGCGTCATCCAGACCGCGCTGGGCCATCAAGTGCATCAGCCGCATCAGGTGCACCAGGAGGCCATCCAGGACGTGTCGATGGGCCTCGATCCGGCTAGCTTCAGTGTCGACGCACTGATGACCACGCGGGACAACAGCGCCGGGCTGATGGCGCGCGACAATCAGCATCACTCGCACCATCCGCACGGTCTCCAGCATCCGCACTCCATTATGAGCAGCAGGGAGTCCATGGGCAGCGGCAGCAGGGACCTGTCGTCCGCGTGCACCACCACGACCACCACGACCGCCGCGGTGGCGGCGATGATGGCCACCACCGGCTACGGGCACAGCAGTACAGTTTCCAGGGGCAACGCCTCACCGCCCGGCACCATGTACACGCCGTATTGCGCACCGGCGGCCGCCGGCTACGCCATCATGGACCACGCCGAGTACAACTCGGCGAGGAATCACGCGAATAACGCCGTAGGACACTCACAGTGGTATCAGGATGCTGCTAGTCCTGATACGGCGATCTATCAGGACACTCAGTCCCCGAGCTGCCAGCTTTACAGATCGAGTCCGCCGACACCGCTCTCGACGGGTGCGGCGCCGTCTCCTCCGCTATATCACCGATATTACCAAGACTGCAACGCCGTCAACACCAGCGGCAATCTTCCGATAACGTTGCACAAGTACTGA
Protein Sequence
MHTLFGEQNAYYRHATAVPVGMGTPSYPGVGAAPGYYEQYRYGGYATAAGYPVSGIGQQHIHHAGKDMVKPPYSYIALIAMAIQNAPDKKITLNGIYQFIMDRFPYYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWSLDPDSYNMFDNGSYLRRRRRFKKKDALKEKEEAMKRQGLVPEKRQEDAKSGSSQVALPPPSDTSAKKLGTLETATGLCKPKREPVNDHTSGNHCMAVQATKYSLHSPIQETKTTTAVAAPGQSVIQTALGHQVHQPHQVHQEAIQDVSMGLDPASFSVDALMTTRDNSAGLMARDNQHHSHHPHGLQHPHSIMSSRESMGSGSRDLSSACTTTTTTTAAVAAMMATTGYGHSSTVSRGNASPPGTMYTPYCAPAAAGYAIMDHAEYNSARNHANNAVGHSQWYQDAASPDTAIYQDTQSPSCQLYRSSPPTPLSTGAAPSPPLYHRYYQDCNAVNTSGNLPITLHKY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01269601; iTF_01270310; iTF_01268076; iTF_01266701; iTF_01268821; iTF_01267353; iTF_01271001; iTF_00085089; iTF_00087735; iTF_00765345; iTF_00126504; iTF_00125712; iTF_00127249; iTF_00127988; iTF_00129530; iTF_00128767; iTF_00884860; iTF_01418817; iTF_00961634; iTF_00962995; iTF_00964288; iTF_00962312; iTF_00963672; iTF_01122238; iTF_01122888; iTF_00965858; iTF_01453890; iTF_01245028; iTF_00867945; iTF_00729099; iTF_00729867; iTF_00730540; iTF_00868574; iTF_00867200; iTF_00109635; iTF_00280459; iTF_00264814; iTF_00264080; iTF_00279775; iTF_01422727; iTF_01421363; iTF_01423447; iTF_01422040; iTF_00452394; iTF_01087021; iTF_01070858; iTF_00306059; iTF_00141644; iTF_00140393; iTF_00684618; iTF_00142288; iTF_01254605; iTF_01077279; iTF_01168977; iTF_00085971; iTF_00417365; iTF_01098999; iTF_00391097; iTF_00633433; iTF_00865817; iTF_00862373; iTF_00860934; iTF_00861693; iTF_00763046; iTF_00865129; iTF_00863083; iTF_00866515; iTF_00231125; iTF_00762360; iTF_00863765; iTF_00860191; iTF_00864447; iTF_00183104; iTF_00183759; iTF_01354425; iTF_01476737; iTF_01477380; iTF_01523172; iTF_01355115; iTF_01475992; iTF_00015195; iTF_00016500; iTF_01228827; iTF_01228196; iTF_01015612; iTF_00385082; iTF_01407970; iTF_01520034; iTF_00014532; iTF_01261672; iTF_00015856; iTF_00182448; iTF_00181781; iTF_00181124; iTF_01405493; iTF_01407034; iTF_01406301; iTF_01408862; iTF_00625307; iTF_00024445; iTF_00733789; iTF_00223681; iTF_00226401; iTF_00216195; iTF_00214212; iTF_00220389; iTF_00218918; iTF_00222343; iTF_00232424; iTF_00221065; iTF_00221737; iTF_00229161; iTF_01417514; iTF_00227083; iTF_00229837; iTF_00983437; iTF_00224366; iTF_00982095; iTF_00214832; iTF_00216880; iTF_00233040; iTF_00873616; iTF_00230514; iTF_01424178; iTF_00982771; iTF_00222997; iTF_00225717; iTF_00219608; iTF_00225048; iTF_00231800; iTF_00217561; iTF_00228473; iTF_00760796; iTF_01420102; iTF_01420743; iTF_01419453; iTF_00683975; iTF_00088586; iTF_01068781; iTF_01065358; iTF_01069455; iTF_01070162; iTF_01067415; iTF_01068089; iTF_01066047; iTF_01066751; iTF_00141070; iTF_01498000; iTF_01539408; iTF_00117809; iTF_00218225; iTF_00675829; iTF_00227766; iTF_00227765; iTF_00360022; iTF_00360715; iTF_00086905; iTF_00084335; iTF_00215514; iTF_01418171; iTF_00302844; iTF_00769437;
90% Identity
iTF_01254605;
80% Identity
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