Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 6.9e-17 2.4e-13 51.2 11.0 5 61 23 79 19 82 0.96

2 8 1.7 5.8e+03 -1.3 7.2 50 62 82 95 80 100 0.77

3 8 0.52 1.8e+03 0.3 25.6 31 61 98 129 92 143 0.77

4 8 8.2e-05 0.29 12.5 21.7 24 61 134 172 128 179 0.80

5 8 1.4 5e+03 -1.1 6.1 49 59 181 191 173 193 0.58

6 8 0.00016 0.56 11.6 19.7 25 61 185 222 182 223 0.85

7 8 0.2 6.8e+02 1.7 3.7 50 61 225 236 222 243 0.74

8 8 0.23 7.9e+02 1.5 9.8 34 50 245 261 236 262 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	6.9e-17	2.4e-13	51.2	11.0	5	61	23	79	19	82	0.96
2	8	1.7	5.8e+03	-1.3	7.2	50	62	82	95	80	100	0.77
3	8	0.52	1.8e+03	0.3	25.6	31	61	98	129	92	143	0.77
4	8	8.2e-05	0.29	12.5	21.7	24	61	134	172	128	179	0.80
5	8	1.4	5e+03	-1.1	6.1	49	59	181	191	173	193	0.58
6	8	0.00016	0.56	11.6	19.7	25	61	185	222	182	223	0.85
7	8	0.2	6.8e+02	1.7	3.7	50	61	225	236	222	243	0.74
8	8	0.23	7.9e+02	1.5	9.8	34	50	245	261	236	262	0.77

Coding Sequence: ATGTTTGATGGCCCATGCATATCACTGTCGGTATTCACAGGCGAATGGGGTCCGAATCCGTCCGGGCCGCTCAACTGCCCGCACTGCGGCTACAGGATCGTGACGTCGACGCACACTAGAGCCTCCATGGGCGCGCACTTTGCTGCAGGGGTCCTCTGCATCTTGGGACTCTGGCCGTGCTGCCTGCTGCCCGACTGCCTGAGCACGTGTCAGAACACGTACCACACGTGTCAGAACACGTACCACACGTGTCAGAACACGTACCACACGTGTCAGAACACGTGCCACACGTGTCATATTGATCCTTGTGTCTGCAGACTCTTGCCGTGCTGCCTGCTGCCCTACTGCCTAAGCACGTGTCAGAACACGTACAATACGTGTCAGAACACGTACAATACGTGTCAGAACACGTGCCACACGTGTCATATTGATCCTTGTGTCTGCAGACTATGGCCGTGCTGCCTGCTGCCCTACTGCCTGAGCACGTGTCAGAACACGTACCACACGTGTCAGAACACGTACAACACGTGTCAGAACACGTGCCACACGTGTCAGAACACGTACCACACGTGTCATATTGATCCTTGTGTCTGCAGACTCTGGCCGTGCTGCCTGCTGCCCTACTGCCTGATCACGTGTCAGAACACGTACCACACGTGTCAGAACACGTACCACACGTGTCAGAACACGTACCACACGTGTCAGAACACGGACCACACGTGTCATATTGATCCTTGTGTCTGCAGACTCTGGCCGTGCTGCCTGCTGCCCTACTGCCTGAGCACGTGA
Protein Sequence: MFDGPCISLSVFTGEWGPNPSGPLNCPHCGYRIVTSTHTRASMGAHFAAGVLCILGLWPCCLLPDCLSTCQNTYHTCQNTYHTCQNTYHTCQNTCHTCHIDPCVCRLLPCCLLPYCLSTCQNTYNTCQNTYNTCQNTCHTCHIDPCVCRLWPCCLLPYCLSTCQNTYHTCQNTYNTCQNTCHTCQNTYHTCHIDPCVCRLWPCCLLPYCLITCQNTYHTCQNTYHTCQNTYHTCQNTDHTCHIDPCVCRLWPCCLLPYCLST

Sequence clustering based on sequence similarity using MMseqs2