Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.3 1.2e+04 -2.3 0.3 8 22 96 110 91 117 0.65

2 3 1.1 3.8e+03 -0.7 0.3 34 44 154 165 138 174 0.55

3 3 1.4e-24 5e-21 75.8 14.2 2 70 219 287 218 287 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.3	1.2e+04	-2.3	0.3	8	22	96	110	91	117	0.65
2	3	1.1	3.8e+03	-0.7	0.3	34	44	154	165	138	174	0.55
3	3	1.4e-24	5e-21	75.8	14.2	2	70	219	287	218	287	0.96

Coding Sequence: ATGGCGCGTGGCCACGAACTGGCCCACGATCAAATTCCCGCCACTCTTGACGTGACTCATGACGTTTCAGGGCAGAGCCGTTCTACTGGTAAATTAAACCATGAGAAACAGTTTTCAAGTAATTCTCTGAAGATGTACGAGCGCCATGCCGCTCGATACTCTCTCTTTTCCTTGTGGACGACAACAGTCCCTGAAGACACGATGCGTACCAACAGCTCTCGTGGTTTGGCAACTCGTGGGTACCAACAGCTGTTGACGCCGGCGCATCGACTCTGCGCAGGAATGTGTTCCACGACGCACGAGACACATCTGACTTCCACTGAGATCAATGATGAAGCTGTTACAGTTTCATATCCACGTAACAGCTTCATCACTGAACTCAGAAGAAAACAGACAGAGGAGCACAGACTCTTGCAGGAGACGCTGCTTGACCAAATGATAGTCTTCATGGTCCCAGGTCTCGTTGTTTTGGGTCTGATTCTGCTCTGCTACTGTCAACCAGCAAGAACTTACTATCTACACGGCTATGGAGCAGGAAGACACTATCACGGCGGTAATCGCAAACACTTCATCTCGGTCCCACGGGCAGCCCCGCTAATGCTGCCGTCCTGCCCGGAAACACACCAGATGATAAAAGCGATAATGGTTGGACCGGATTCTGTCCCAATGATATGTCCAAGTTGTCACCATGAAGTCACTACCATAGTTACAAGAGAGCCTTCCACAAGTGCTCACTTAGCGGCGTTAACTCTCTGTGCGTTTGGGTTCTGGCTGTGCTGCTGCGTCCCGTACTGCCTGGAGAGCTGCCAGAACTCGCGCCACACTTGTCCCAACTGCGCTGCATTCCGCGGTACTTACAAGCCGTAG
Protein Sequence: MARGHELAHDQIPATLDVTHDVSGQSRSTGKLNHEKQFSSNSLKMYERHAARYSLFSLWTTTVPEDTMRTNSSRGLATRGYQQLLTPAHRLCAGMCSTTHETHLTSTEINDEAVTVSYPRNSFITELRRKQTEEHRLLQETLLDQMIVFMVPGLVVLGLILLCYCQPARTYYLHGYGAGRHYHGGNRKHFISVPRAAPLMLPSCPETHQMIKAIMVGPDSVPMICPSCHHEVTTIVTREPSTSAHLAALTLCAFGFWLCCCVPYCLESCQNSRHTCPNCAAFRGTYKP

Sequence clustering based on sequence similarity using MMseqs2