Lnig007292.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Leuctra nigra
Gene Symbol
MBD-R2
Assembly
GCA_934046545.1
Location
CAKOHC010000573.1:176511-202580[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.2 2.3e+04 -3.7 0.0 18 38 111 131 96 135 0.75
2 2 8.8e-22 6.2e-18 65.4 0.3 6 74 258 326 253 329 0.92

Sequence Information

Coding Sequence
ATGCTGGATGAATCAGACATGTCTCTGGTTTCCAACAGCGGCAAAACATCAGAATGCGGCTACCGTGTCGGGGAGACTGTAATGGCTATTTGGACGGATTGTCGGAAATATCCAGCCAAAGTGAAGGCAATTCTTAGTGCAGATAAAGTTGAAGTGTTGTTCTTCGACGGTTTCTCGAAAGCgatgaaaattaacaaaatatcgAAGTTTGGTGGTGATTTAGAGATTCAGCCTGAAAAGCCGCCATTCGGAGCGGCAACTATGACGAAGGCGGAAAGACGTGAGCGCAATCGTAAGATCGAGTCTGTCGCTGATCTGTTTCACATGAAGAGGTTCAGGAAGCCCAAGGAGGAACGGAAAAGCAACGACACTTGCACTGTGTTCACTTCTCCGGAACCCCAGAAAGCAGTGGAACCCGTTGTCGATGCAAAGCCACCTGAACGAGAAGTATCGATGAGCGACAACGAGGGGGAGAAGATGTACATCAACCTTGATGCCAGCTTCAGCAAGGACGAGTCACCGGCCGACACGCCACCCAAGAAGCCTGTCGTGAAGCGGCCCAAGCCGCAGCAGCCCGAAGGCAAGAGGAGGAAGCGGACATACAACAGAGTGTTCCTGGACAGCTCGCCCGCCGGCACTTTGAGGGAGGTTCATCCCGGAAGAGCTCGGAACCCCGAGGGCGGCCCCTCGGACGACCTTGACAACTGGGAGCCGGACGGAGACGAAGCCTACGTCGTCGAGTCGAGCGACGGGCTGCGTCGGAGCATCATCGTGGCCGACGACCGCCTGCCTCGGGGCTGGGAGAAGCACACGATCCAGCGACGCAGCGGCAACTCGGCCGGCAAGTGGGACGTGTTCCTCGTCAGTCCCACCGGCCGGCGGTTCCGCTCGCGCAAGGAGATGTCCTCGTACTTCGCAGAGACCAAGGAGGTCTACGAGCCACATCTGTACGACTTCACTCTCAGATGCACGATGAGGCGCAAGAGGCGAGGCACCCAGTACGTGAGGCCGGTGGCCGCCTACGCGAAGAGGAGGCATCAGAAGGGGCGCGCGAAGCCGCCGCACACCCTGCCGTCGAGCGAGTCGGACGGCGCGAAGCCCGAGGGGCTGGAGACGCCGCAGCGCAAGACGGCGGCCAAGTCAGGCGGCAAGCAAGGCGGCCGGGCGTCGACGGGCAAGGCGCCGGCCAAGCCCTCGGGCAGCGGGACGGTCTTCGAGACACCGACGCAGGTCAAGCTCGAGGCGGAGAAACTGCCGCCACCGGACGAGGGCAAAGTGTACGTGGGACAGATGCAGGTCGAGATGGATCTGGACGGAGGCTTCGTGTGTCCCAAGGAGGGCTGCTTGAAACACTTCCGCAAGGAGAACCTCCTGCAGATGCACATCAAGCACTACCATCCCGAGTACAACAAGTTCATGGGCTCCACCCCGAACGTCGCGGACTTGGCTTACGCGCGCACCGTGGGCGAGCCGATCGAGGACATCGTGCCGTGCGGCCGCGCGCTCGACTCCGCCTTCTTCGAGAGCATCAACAGGTTCGAGGCGACGCGCAAGCCCGCGCCCCCCCCGCCTGCGCCACCCACGCAGAGGAAGGAGGAGGCGGGGCCGGTCGCAGTGCCCATTGAGGGGAAGAAGGTCCTCAGAGTCGTGCTGACGGACCACGTGAAGGTGAAGGAGGAGCCGACGCCCGCCGAGCCAGCCAAGCCGGTCTCCTCTCCGCTGAGGGATCTGCTGCGAGAGCATCCCAAGCCCGGCGTCACGGCCGGCATCAAGACACTGCTGCCCGTCAGCCGACCCTCCACCAGCAAGACAACCATGGATCCGACGGTGGAGTGGCGGAGCGGGTCGAGCGGCGTCGCTGCCAAGCCCAAGATGCGCAAGCGCAGGCTGTCCGATGCCTACATGGAGTCACTCAAGCGCAAGAAACTCGCCAAGAGAGCTGCAGAGTCGTCCAGCAGCGAAGTGAGCAGCAGCGACACGTTCCTCACGCCCACGCACATTCGTCCGCACAAGAAGCTGCCGCTGCTGGCAGCCAGCCTGGCGCGGCCGCCGCTTCTGCCGGAGCAGTTCAACTCAAGCGAGCTGACGGCGACGCGAGCCCCGGAGATGACCCAGGAGCAGCTGAACAAGCGAGACATCATCAACTGCACGTGCGGCGTGATGGAGGAGGACGGACTCATGATCCAGTGCGACCTGTGCCTGTGCTGGCAGCACGGCTACTGCAACGCCATCGAGAGCGAGCGCCAGGTGCCGGACAAGTACGTGTGCGCCATCTGCCTGCGTCCGGCGCGCGCCCGGCGCTCCCTGCGCCACCGCCACGACCAGACCTGGCTCAAGGAGGGCGCGCTGCCGTCGGCGGCCAAGCTGCGCGGGACCGGTACGACCGAGAGTGCGCCGCGCACCTCGCTGCTGCGCCAGTCGCACGCGCTCACCGGCGCGCTGCTGGGCGTGAACACCGCGCTGCGCAGCCTGCGCGCCAAGGTCAACGTCGCAGATGCATCGGACCATCCTAAGCTGTACCTGTGGGCCAAGCCGTGGTCCAAGACCGCACTCAACGTGACCGACGAGGCCGAGACCAAGTCCGACGCCGAAGTGAAGACGGAAGTGTTCGAGGCAGAGGAGAAGAAGGCGGAGGAGGAGAAACCAAACACCGACGCCATTGGGGGGTCCAAGATCCTGCTCCAGGCGCTGACGAGCGGAGCGACCAGTTCGAGCGCCCCGCTGGACGACAAGCAGCTGTTCGATCTGCCCATCTCCCAGTCCGAACTGCTCCACTTCGCCAGCTCCATGGCCGACAACCTCGACCGAACACCCGCGCCCGAGCCCGAGAAGCCGATCGACCCCGGCGAGTGTCGCTCGCTCCTGCTCGACCACATCGAGCACGACCAGCGCCAGCTCATGCGCTCGCTCGACCAGATCGCCAGACACATCACCGCGTTGGAAGCAGCAGACCCGGAACCTCCGCCGCAAGAATCCGTCGAGTTCTGTCCGCGCACCAAACACACCATCCAGATGTTGTTGCGCGACCTGTCCACCGTGCGCAACATCGCGGCGCTGTAG
Protein Sequence
MLDESDMSLVSNSGKTSECGYRVGETVMAIWTDCRKYPAKVKAILSADKVEVLFFDGFSKAMKINKISKFGGDLEIQPEKPPFGAATMTKAERRERNRKIESVADLFHMKRFRKPKEERKSNDTCTVFTSPEPQKAVEPVVDAKPPEREVSMSDNEGEKMYINLDASFSKDESPADTPPKKPVVKRPKPQQPEGKRRKRTYNRVFLDSSPAGTLREVHPGRARNPEGGPSDDLDNWEPDGDEAYVVESSDGLRRSIIVADDRLPRGWEKHTIQRRSGNSAGKWDVFLVSPTGRRFRSRKEMSSYFAETKEVYEPHLYDFTLRCTMRRKRRGTQYVRPVAAYAKRRHQKGRAKPPHTLPSSESDGAKPEGLETPQRKTAAKSGGKQGGRASTGKAPAKPSGSGTVFETPTQVKLEAEKLPPPDEGKVYVGQMQVEMDLDGGFVCPKEGCLKHFRKENLLQMHIKHYHPEYNKFMGSTPNVADLAYARTVGEPIEDIVPCGRALDSAFFESINRFEATRKPAPPPPAPPTQRKEEAGPVAVPIEGKKVLRVVLTDHVKVKEEPTPAEPAKPVSSPLRDLLREHPKPGVTAGIKTLLPVSRPSTSKTTMDPTVEWRSGSSGVAAKPKMRKRRLSDAYMESLKRKKLAKRAAESSSSEVSSSDTFLTPTHIRPHKKLPLLAASLARPPLLPEQFNSSELTATRAPEMTQEQLNKRDIINCTCGVMEEDGLMIQCDLCLCWQHGYCNAIESERQVPDKYVCAICLRPARARRSLRHRHDQTWLKEGALPSAAKLRGTGTTESAPRTSLLRQSHALTGALLGVNTALRSLRAKVNVADASDHPKLYLWAKPWSKTALNVTDEAETKSDAEVKTEVFEAEEKKAEEEKPNTDAIGGSKILLQALTSGATSSSAPLDDKQLFDLPISQSELLHFASSMADNLDRTPAPEPEKPIDPGECRSLLLDHIEHDQRQLMRSLDQIARHITALEAADPEPPPQESVEFCPRTKHTIQMLLRDLSTVRNIAAL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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