Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0034 48 5.0 0.0 3 49 10 54 8 57 0.78

2 6 0.0087 1.2e+02 3.7 0.0 6 49 60 101 55 104 0.63

3 6 0.0087 1.2e+02 3.7 0.0 6 49 107 148 102 151 0.63

4 6 0.0093 1.3e+02 3.6 0.0 6 49 154 195 149 197 0.62

5 6 0.0087 1.2e+02 3.7 0.0 6 49 201 242 196 245 0.63

6 6 0.0087 1.2e+02 3.7 0.0 6 49 248 289 243 292 0.63

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0034	48	5.0	3	49	10	54	8	57	0.78
2	6	0.0087	1.2e+02	3.7	6	49	60	101	55	104	0.63
3	6	0.0087	1.2e+02	3.7	6	49	107	148	102	151	0.63
4	6	0.0093	1.3e+02	3.6	6	49	154	195	149	197	0.62
5	6	0.0087	1.2e+02	3.7	6	49	201	242	196	245	0.63
6	6	0.0087	1.2e+02	3.7	6	49	248	289	243	292	0.63

Coding Sequence: ATGGCCAATGTACTCGAGTCATCAACATCCTCGTTAGCTCTGTTTACCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCGTTAGCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCGTTAGCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCGTTAGCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCGTTAGCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCATCGTTAGCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCGTTAGCTCTGTTTGCCGAAGAAGTCCAGCAGGATATTCTCCATGGCCAATGTACTCGAGTCATCAACATCCTCGTTAGCTCTGTTTGCCGAAGAAGTCCAGCAGTCGCTCAAAACCCCGCAGGAATCCCTCGTTAG
Protein Sequence: MANVLESSTSSLALFTEEVQQDILHGQCTRVINILLCLPKKSSRIFSMANVLESSTSSLALFAEEVQQDILHGQCTRVINILLCLPKKSSRIFSMANVLESSTSSLALFAEEVQQDILHGQCTRVINILLCLPKKSSRIFSMANVLESSTSSLALFAEEVQQDILHGQCTRVINILLCLPKKSSRIFSMANVLESSTSSLALFAEEVQQDILHGQCTRVINILLCLPKKSSRIFSMANVLESSTSSLALFAEEVQQDILHGQCTRVINILLCLPKKSSRIFSMANVLESSTSSLALFAEEVQQDILHGQCTRVINILVSSVCRRSPAVAQNPAGIPR

Sequence clustering based on sequence similarity using MMseqs2