Basic Information

Insect: Leucania comma
Gene Symbol: topi
Assembly: GCA_958295575.1
Location: OY282482.1:6068692-6076920[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.0031 0.33 12.7 2.1 2 23 73 94 72 94 0.96

2 12 0.024 2.5 9.9 0.3 2 23 101 123 100 123 0.94

3 12 0.39 42 6.0 0.4 2 23 131 153 130 153 0.90

4 12 2.9e-05 0.0031 19.0 2.2 1 23 159 181 159 181 0.96

5 12 7.6e-08 8.1e-06 27.2 2.2 1 23 187 209 187 209 0.96

6 12 0.00062 0.067 14.8 1.3 1 20 215 234 215 236 0.93

7 12 0.2 22 6.9 2.4 3 19 256 272 255 277 0.92

8 12 1.9e-05 0.002 19.6 1.8 1 23 598 620 598 620 0.98

9 12 3.5e-06 0.00038 21.9 4.1 1 23 627 650 627 650 0.97

10 12 0.11 12 7.8 5.8 1 23 658 681 658 681 0.93

11 12 0.008 0.85 11.4 3.5 2 23 688 711 687 711 0.92

12 12 0.00038 0.041 15.5 0.9 1 21 717 737 717 738 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.0031	0.33	12.7	2.1	2	23	73	94	72	94	0.96
2	12	0.024	2.5	9.9	0.3	2	23	101	123	100	123	0.94
3	12	0.39	42	6.0	0.4	2	23	131	153	130	153	0.90
4	12	2.9e-05	0.0031	19.0	2.2	1	23	159	181	159	181	0.96
5	12	7.6e-08	8.1e-06	27.2	2.2	1	23	187	209	187	209	0.96
6	12	0.00062	0.067	14.8	1.3	1	20	215	234	215	236	0.93
7	12	0.2	22	6.9	2.4	3	19	256	272	255	277	0.92
8	12	1.9e-05	0.002	19.6	1.8	1	23	598	620	598	620	0.98
9	12	3.5e-06	0.00038	21.9	4.1	1	23	627	650	627	650	0.97
10	12	0.11	12	7.8	5.8	1	23	658	681	658	681	0.93
11	12	0.008	0.85	11.4	3.5	2	23	688	711	687	711	0.92
12	12	0.00038	0.041	15.5	0.9	1	21	717	737	717	738	0.95

Sequence Information

Coding Sequence: ATGGATTCGAATTTACCATTTTTTAGTCTCCcattcgTGGATTCGGAGACTTCAGATTTTTTATCGAGGATCAAGCCGCAGGAGTGTGCGTACGATGAGTTGCAGGCTACCTTACCATCCCATGGAGCTTTGCTGGGCCCCGACGATGTCTTGGCCCAGTTCCTTTCTGGAGACGAGCCTCTAGAAGAGCCCGATTTAAACGGCCCAACTACGTTACACTGTGAGATCTGTAAGAAGCGGTTTGATAATGCAAAGAAGTACTATGGACATTTACGAGTTCATTCCAAGGATAATCTTTGGGTTTGTGAGCAATGTCCTGATCAGAAGTTTTCCACGAAACAGCTGCTGATGAAGCATGGGTTAACTCACAAGCCTCTGGAGAGAGAATGGAAGTGCCTGCAGTGTACGATGGCCTTCGAGGCTCTGTACAAACTGCAGCAGCATCTGTTTGCTAAACATTTGAACTACAAGCCCCACAACTGCGATCAATGCGAGAAGTCTTTTACGAAGGCTTCAGACTTGGAGAAACATAAGAGCATACATAGTGATGTAAAGAGACATGCGTGTCCTGAGTGCGACATGCGCTTCAAGGACAAGTCGAACCTGAAGCGGCACATGCTGCGACACAACGGCACTAAGCCTTATTGTTGCACGGGATGTGGGACGAGGTTTAAACAGCTGGCGTCCATGAAGCGCCACGCGCAGAACTGCGCGCTCAGCAAATGTTGCAGCGAGCCAGCGGACACGCGCACTCGCAAGAACCACTGCCGAGTGTGCGGCATGAGCTTCCAGTACAAGAGCGCCTTGTTAGAGCACTGCGTCAGGCAACATACCGAAGCGGGGGGTACTGCTCAAAACGCGAAGCCGCCAGAACCCGACAAAGATGATAAAAGCAATCTAAATGACACGAACCGCATCGTAGACAACATCGTGGACGATATCCTCTCCGCCGAAGACGACTACATGACCATGTCGACACAGAACGAGATACTGAACGTCTACAACCCAAATGATATCGACAACAATCCGGAAAACTTGATGCAAATAGAACTATTAAAAGAAATGAATCAACTGCACATTTTAGATGGAGAACTTTTCTACAATGATATAGACTTCGACAGCATCCAACCTAGCCACATGTTTAACACAAACACGAATGACATGGACTATAGTGCTGATAAAAATGCAGAGATTCTATTCGATTTTACTGAAGGAAACAAAAGTATGGATCAAGATATCATGAACACTTTGTTCCATGTCAAAGCAGAGTACTTACCTGATGAATTACTAAATCCACCAGAAATAATAAATCCTCCTGAGAAAAATAACGAACTAGACAATCATAACCACGTGTCTGTGAATGAATGTGCTACGATATTTGAAAGTGACGTAGATTTAGAAGCTAGCACGAATCTAGCTGCTAATTTGAACCAATTGATTGGTGAAAATAGTGTCCAGTATATCTCGACAGAAGACGATGACACCtttataattagtttaaatAGTGAAATTGATGCTGAACAGTTGACGGATATGTTAAATATAGGAGTAGAATTAGTTAATGATAAGCCTAAGGAGCCAAGTGTACCTGAAGTGAAACAGGAAACTGTGAGTTTAGCAAATATAGAGCTATATGTCAAGATTGATAAGCAGACAAAAGAGCCACAGAACGAGCAATTAGGACCTATGGTTATTAAACTGGAAGATCCTATGAGTGCACCGCCTATGGGTTTGATAGCCAAAGAGGAACAAAAGAAAGTAAAGAAGAGAAAGCCTAAGAAGAAAGTGTTGTATGTTTGTAGAACTTGCAATAAGGCGTTTAATAAGAAAGATAATTATAGATCTCACCTagCAACCCACGAGCCATCTCTCCGGCGGCACAAGTGTAAGGTGTGCGGGGAACGCTTCAGCTACCGCTCCACGCTCAACAAGCACACGCGCAGTCTGCACACGCCCTATGTCCAGGAGGAGCACTGCTGTCACATATGCGAGCGCAACTTCAAGTTCGCCTGGATGTTGCGAGAGCACTTCGAACGCGACCACGACGGCCTGACGCCGCATGCGTGCGACTATAAAGACTGTCGCAAAAGTTTCTTCAAGAAATCAGATCTCGTCGTGCATAAGAGGTTCCACACTGGCGAGCGTCCGTACTCGTGCGATATCTGCAAGAGAAGGTTCCTGCAGGCGAGCCATCTCAAGCGGCACGAGAGGGCCGTCGACTGCACCAAGTTCATCACCAAATCGGAACCGCTGCCTCAAAAAGACAAGGAGCACAAACtgtga
Protein Sequence: MDSNLPFFSLPFVDSETSDFLSRIKPQECAYDELQATLPSHGALLGPDDVLAQFLSGDEPLEEPDLNGPTTLHCEICKKRFDNAKKYYGHLRVHSKDNLWVCEQCPDQKFSTKQLLMKHGLTHKPLEREWKCLQCTMAFEALYKLQQHLFAKHLNYKPHNCDQCEKSFTKASDLEKHKSIHSDVKRHACPECDMRFKDKSNLKRHMLRHNGTKPYCCTGCGTRFKQLASMKRHAQNCALSKCCSEPADTRTRKNHCRVCGMSFQYKSALLEHCVRQHTEAGGTAQNAKPPEPDKDDKSNLNDTNRIVDNIVDDILSAEDDYMTMSTQNEILNVYNPNDIDNNPENLMQIELLKEMNQLHILDGELFYNDIDFDSIQPSHMFNTNTNDMDYSADKNAEILFDFTEGNKSMDQDIMNTLFHVKAEYLPDELLNPPEIINPPEKNNELDNHNHVSVNECATIFESDVDLEASTNLAANLNQLIGENSVQYISTEDDDTFIISLNSEIDAEQLTDMLNIGVELVNDKPKEPSVPEVKQETVSLANIELYVKIDKQTKEPQNEQLGPMVIKLEDPMSAPPMGLIAKEEQKKVKKRKPKKKVLYVCRTCNKAFNKKDNYRSHLATHEPSLRRHKCKVCGERFSYRSTLNKHTRSLHTPYVQEEHCCHICERNFKFAWMLREHFERDHDGLTPHACDYKDCRKSFFKKSDLVVHKRFHTGERPYSCDICKRRFLQASHLKRHERAVDCTKFITKSEPLPQKDKEHKL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01527643;
90% Identity: iTF_01030495;
80% Identity: -