Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.8e-35 8e-33 112.8 0.1 2 108 173 277 172 279 0.96

2 2 8 2.3e+03 -1.3 0.0 80 109 281 310 276 311 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.8e-35	8e-33	112.8	0.1	2	108	173	277	172	279	0.96
2	2	8	2.3e+03	-1.3	0.0	80	109	281	310	276	311	0.82

Coding Sequence: ATGGGATATTTTTTAATAAATGATGTTAAGGTGGTGAAGTTCAGTTACATGTGGACTATAAACAATTTTAGTTTTTGTAGAGAGGAGATGGGTGAAGTGTTAAAATCATCGACATTCTCAGCCGGTGCTAGTGACAAGTTAAAGTGGTGTCTTCGCGTTAACCCTAAAGGACTCGATGAAGAGAGCAAAGACTATTTATCATTATATTTATTATTAGTGTCGTGTAATAAATCAGAAGTGCGTGCGAAGTTCAAGTTTTCAATATTAAACGCCAAACGGGAAGAAACGAAAGCGATGGAGTCACAAAGAGCGTACAGATTTGTGCAGGGAAAGGATTGGGGATTCAAAAAGTTTATAAGAAGAGATTTCCTCTTAGACGAAGCAAACGGCCTGCTACCTGAAGACAAGCTGACGATATTCTGCGAGGTGTCAGTGGTGGCAGACAGTATCAACATCAGCGGTCAGAGTAACGTGGTCCAGTTCAAAGTCCCCGAGTGTAGACTCTCGGATGACTTGGGCGCGCTCTTCGACAATGAGAGATTTTCTGACGTCACGTTGGCAGTGGGAGGAAGGGAGTTCCAAGCGCATAAAGCTATTCTAGCAGCGCGGAGTCCAGTGTTCGCGGCGATGTTCGAGCACGAGATGGAGGAGAGGAAGAGGAACCGAGTGGACATCACGGACGTGGACCACGAGGTGTTGAGAGAGATGTTGCGCTTCATATACACGGACCGGGCGCCGAACCTCGACAAGATGGCCGATGACTTACTGGCGGCGGCGGATAAGTACGCGTTGGACCGGTTAAAGGTGATGTGCGAGGAGGCGCTGTGCCTCAGTCTGTCAGTGGAGACGGCGGCCGACACCCTCATACTGGCTGACCTGCACTCCGCCGACCAACTCAAAGCGCAGACCATAGATTTTATTAACACGAGTCACGCAACAGACGTGATGGACACGGCGGGCTGGAAGAACATGATATCGTCTCACCCGCACCTCATAGCGGAGGCGTTCCGCGCGCTCGCCACGCAGCAACAACAGATCCCGCCCATCGGCCCGCCGCGCAAGCGAGTCAAGCAGGCCTAG
Protein Sequence: MGYFLINDVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAGASDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPEDKLTIFCEVSVVADSINISGQSNVVQFKVPECRLSDDLGALFDNERFSDVTLAVGGREFQAHKAILAARSPVFAAMFEHEMEERKRNRVDITDVDHEVLREMLRFIYTDRAPNLDKMADDLLAAADKYALDRLKVMCEEALCLSLSVETAADTLILADLHSADQLKAQTIDFINTSHATDVMDTAGWKNMISSHPHLIAEAFRALATQQQQIPPIGPPRKRVKQA

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00372211;
90% Identity: iTF_00782733;
80% Identity: iTF_00795809; iTF_01159521; iTF_00781922; iTF_01154210; iTF_00779587; iTF_00777441; iTF_01439139; iTF_01147461; iTF_01144630; iTF_01149687; iTF_00621320; iTF_01142473; iTF_00778090; iTF_00971468; iTF_00970508; iTF_01078316; iTF_01079155; iTF_00840374; iTF_00775350; iTF_00204440; iTF_00673594; iTF_00781115; iTF_00249789;