Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_032872505.1
Location
CM065468.1:24723243-24726557[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.6e-14 1.2e-10 42.1 0.1 6 69 396 459 391 467 0.90
2 2 0.37 2.9e+03 -0.7 0.0 43 76 971 1004 970 1005 0.86

Sequence Information

Coding Sequence
ATGTCCATGAAATCTCCTACAACTTATTCTCAAGACGACTTGGACCTTATAAATTCAGAAATTTCTCATTTCCATTATTCCACACCAacaacatcatcatcatcatctgaGAATCAAAATCAACCGAAAACGACGATAAATACAGAAAGATTTTACAATAATGTAGaggaattttcaaatacattaaaTCCACTAAATATTGACGAACTACAAAATGCCTAcaatattgatttaataaataatctatCGGGAAAAtcagaatttattgaaaatgaaaatataccaatttcaattaataattcaacGGGTAATGTTCAACCTCTTATGACAATAGAAAATGTTGCTGCAAATTTTCATCCAGAGGACGGTAATATTAGATTTCAGTGCGAGAAGAAAAGTGAGAAAGCTGACGAATTAAagagtaaacaaataaaaggTTTAAACTTTTTTCCTGGCGATAAACTCGAGGCAAAGGATTTCAATGAGAAATGGTATACGGCAAAAGTTGTTGAAACCGATTGGGTCGAAAGAGAAGTTCTGATTCATTTCGATAAATGGAGTGCAAGATTTGATGAATGGATACCTATGGATAGTCCACGATTACGAATGTTACAAACACAATCACGTGAAATGAAGACAAAGGATTTTGTCGCGGGCGAAAGAATTCTCGCCACATGGGCCGATGGCAGAAAATATCCAGCGAAAGTCAACGCTGTTTTGGGAAATGATCGTTACGATGTACTATTCGACGATGGTTACACGAAAATTGTGAGATCATCGAAAATGTCAAAATTAGGTGGACCTCTCGACGAGCAGAATGACAGTGAGGATTTCATTGGCAGTAAGGAGAAGCGCAAGGATAGAAATCGAAAATATCAGGTTATGGATCTCTTTCAGCGTAAACCAAAGAAAGGCGGTGAGATTAAGTATGCGAAAAGAGGTCGTCCTTGCAAGGAGGAAATAGTCCCGGAGCCATTGATCGATAATGGCTCGTTCTCCGGCTCTCATGACGATTCAAGTACGGAGGTGCTCCACGGTTTTGAAAATCCCACCGCAAAAGTGAAGACTTACATgaagaaggagaaaaaagatTCGAACATCGATCCTAGTTTTCAGCCCGAATGGAAGGATGGCGAACCACAAGGAATTGAGTCGTTTATCGAGGGACCACGACGATCGATTATTGTCGCTGATAAAAGACTACCACCCGGATGGGTGAAACACTTCACCCAGAGGAAGGCGGGATCGTCAGCTGGCAAGTGGGACGTACTCTTCATCCACGAGGGCAGTGACAAGAAATTCCGTTCTCGAAACGACATCCGTGCGTATATGGTGAGTCAGGGGCAATTCGACTTCGATCCGGAGATGTTCGACTTTTGTATTCATCGAAAGAAGAAGGCGAGGGGTGAGAAGGTAATTTCAGACACACCACCTGCTAGAAGATCGAAATCATCCTCGAGAGCAATTCCGAGTCCTCTACTGCCTGTAACTCCGATTCCAGTCACGCCAGCACCAGCTTTACTCGAAAACAGTGCAGTATTCATCGGCGGTCTACGTGTCGAAATGGAGGACAGCTCCTACAAGTGTCCAAAGGATGGTTGTCTAAAGAATTTCCGGAAAGAAAATCTTTTGCAGATGCACATCAAACACTACCATCCGGAGTACTCAAAATTTCTCGGTTCAACACCGAATGTCGCCGATTTGGCTTATGCAAGAACAATCGGCGAGTCTATCGACGACATCATCCCTAAGCAAACGCACAATTTTCTGGAGAAAATCAACAAGtttgagaagaaaaaagaaaaatcccaACTGCCCGTTCTTCAGGCTCTTTCGCCATCGCAGCCGATCGCCACTGCGCCATCGCCAACGCCGCCTGTCCTCGAACTCGAGGTCAACCGAACCGAGGAAAGTATTCCAAAAGACGAGAAAATCGAATTAGGATCGCCCTTGAGAACCAACAGCGAGACTCTCCGCAAGGAAACCGATTGCGCAATGTCGCCAGGATCCCTCTTCGATCTGAAGATCCGAGAGGAAAAAACTAGTGGCATTAAAACTCTCCTCCCAGTTCGTGCGCCAGACTCGAGATCAAAATCCGTCGACGAAATGATGACACCAGGCCAACGGGGCAAAAGTTTGAGAAAACGTAACCTTACGGACTATCATCCAGATATTCCCCGCGTAAAGAAACGACAGAGTATTCAAGATTCTAATTTCGAGGATTTGGACGAGAGTACAATGGACACGGAGGGCCCCGCCACTCCCACCTATCGTTTCAGTCGACGAAAATCCGACGCCAAGAACGACGAGAGCAATGACAGTAAACACGAGGGTATGATGCTGATCAATGGCGAATTGATAAAAGTCGAACAACTCCGCAAGGAGGAAATTATCAACTGCACTTGTAAATTTATGGAAGAGGACGGTCTCATGATCCAATGTGATCTTTGCCTCTGTTGGCAGCACGGTCACTGCAACGCCATCGAGAAAGAAAAAGACGTTCCCGACAAGTACGTCTGCTACATCTGTCGTCATCCCCACCGTCAACGACCATCAATGAAATACAATCTCGATCAAGAATGGATGAAGGAAGGCAAGTTACCAACTCTCTCGATCAGCACCAAAAACAACGACCTCGCCTTCAAGCAACGCACCGCAATGCTAAAACGCTCCTACGATCTTATCTCCTTCTTATTCCAAATCCAACACCTCCTTCACAGTCTCCGCGTGAAAATTAACGTCGCACAAAAAAAGGACCATCCCAAACTCTATCTATGGGCGAAAAATTGGGAGAAATTCCTAATTCCAAAACCTGACATTTCGCCCGTGCCGATTTTGGAAATAATCGAAAACACCGAAACAGTGGCCGAAGTGAAAAAGGAAGAAAACGATAATACACCAGAAATTAAAATCACAACTGATTCCGATTTGGTAAAAATACTCGAAGACGGTGCACTTGCCGATGACacgaaaaaggaaaattttctattcagcGCATTGACGAAAAGTGAGGATAAAACAGAAAGTggtctaaaagaaaatttaaagacaCCATTGGAATCGAAACCATTTATTCCCGAACCTGAAGCACCGATTGATCCCACAGAATGTCGAATGAGACTCCTGGAGCATATTGATCATTTTCAAAACTATGTTGCTTCAAAATTGACGAGCATTGAAGCACAAGTTCAAGTTTTGGAGGAAATGGATCCGGATACAATTCCTGAAATTGAAGTTCAACCGAGAACGAAGCAAACTGTGCAAATGTTACTTCGTGATTTGGGCACCATCAGAAAACTTGCTTCATTgtgttga
Protein Sequence
MSMKSPTTYSQDDLDLINSEISHFHYSTPTTSSSSSENQNQPKTTINTERFYNNVEEFSNTLNPLNIDELQNAYNIDLINNLSGKSEFIENENIPISINNSTGNVQPLMTIENVAANFHPEDGNIRFQCEKKSEKADELKSKQIKGLNFFPGDKLEAKDFNEKWYTAKVVETDWVEREVLIHFDKWSARFDEWIPMDSPRLRMLQTQSREMKTKDFVAGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYTKIVRSSKMSKLGGPLDEQNDSEDFIGSKEKRKDRNRKYQVMDLFQRKPKKGGEIKYAKRGRPCKEEIVPEPLIDNGSFSGSHDDSSTEVLHGFENPTAKVKTYMKKEKKDSNIDPSFQPEWKDGEPQGIESFIEGPRRSIIVADKRLPPGWVKHFTQRKAGSSAGKWDVLFIHEGSDKKFRSRNDIRAYMVSQGQFDFDPEMFDFCIHRKKKARGEKVISDTPPARRSKSSSRAIPSPLLPVTPIPVTPAPALLENSAVFIGGLRVEMEDSSYKCPKDGCLKNFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIDDIIPKQTHNFLEKINKFEKKKEKSQLPVLQALSPSQPIATAPSPTPPVLELEVNRTEESIPKDEKIELGSPLRTNSETLRKETDCAMSPGSLFDLKIREEKTSGIKTLLPVRAPDSRSKSVDEMMTPGQRGKSLRKRNLTDYHPDIPRVKKRQSIQDSNFEDLDESTMDTEGPATPTYRFSRRKSDAKNDESNDSKHEGMMLINGELIKVEQLRKEEIINCTCKFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPDKYVCYICRHPHRQRPSMKYNLDQEWMKEGKLPTLSISTKNNDLAFKQRTAMLKRSYDLISFLFQIQHLLHSLRVKINVAQKKDHPKLYLWAKNWEKFLIPKPDISPVPILEIIENTETVAEVKKEENDNTPEIKITTDSDLVKILEDGALADDTKKENFLFSALTKSEDKTESGLKENLKTPLESKPFIPEPEAPIDPTECRMRLLEHIDHFQNYVASKLTSIEAQVQVLEEMDPDTIPEIEVQPRTKQTVQMLLRDLGTIRKLASLC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00880450;
90% Identity
iTF_00881247;
80% Identity
-