Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.043 1e+03 -1.0 0.6 4 28 7 31 5 35 0.80

2 5 4e-07 0.0096 15.6 0.0 25 79 49 106 42 113 0.76

3 5 1 2.4e+04 -18.6 32.5 440 487 116 155 101 171 0.41

4 5 1 2.4e+04 -6.3 20.3 443 487 199 241 187 256 0.63

5 5 7.1e-08 0.0017 18.1 0.3 339 382 262 305 243 313 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.043	1e+03	-1.0	0.6	4	28	7	31	5	35	0.80
2	5	4e-07	0.0096	15.6	0.0	25	79	49	106	42	113	0.76
3	5	1	2.4e+04	-18.6	32.5	440	487	116	155	101	171	0.41
4	5	1	2.4e+04	-6.3	20.3	443	487	199	241	187	256	0.63
5	5	7.1e-08	0.0017	18.1	0.3	339	382	262	305	243	313	0.75

Coding Sequence: ATGGGGAGGCCACGtgtgGAAAGGGACCGACTTCGAGAGCGGGAACGACAAGCCCGCGCAGCGATGTCGGTCCAGGCGGAGCAGGCAGCAGCTGGAGGTGCTCCTGACTCTCGGCACGGTCATCACAATCATGGACATCATGCCGATTCGCACGCTGCTACCGCTTCCCTCTTTCGTGCTCCTGTTAAGGTGAATCCCGATGCTCAAGATCGAACGACACAACAGATCCAGTCGAAATTGGGTAACTATTCGGTGGTGAGGCACCTGCTCGAGGATCCAAAGAGGCTGATTGGAATCGATGGGGTGCCAGCGAGTCCAGCACCGGCTCATTCATCGAGGCTCGCCAGCAGCTCTGGTTCGAGTTCAAGAAGCTCGCCATCGTCACAGGAGTTTAAAAAACCTGGGGGGCCCAGGTCAAGTTCATCTTCGAATtcatcatcgtcatcatcatcGAGTCACGCCTCGGCGCAACGTGGTGGTTTCGTTAAACCTGCCGATGGGAAACCACCCTACGGTGGTCGTGGTGGTTATCCAGGACAACCAGTGAAGCATGGTGGCAATAGTAATGATCATCGTAGTCATGGTTTACTTCCGGCAAAGGGTCCTCCACCTCCTTCAAACTCATCAGGAAGCGGTAATTCAAACGTTGGCAGTAGTATTGCCAATAGCAATAACAACAGCAGCAGTAATAGTAGCAACAGCAGCAGCAGTAGCAACAGTAATCGACTTCATAACGCCGGTAGCCGTCTGCCGAGAATTAACCTCGATAAtgGCATCAATTCGAGGCAGACTCTCGAGGAAAATACACCAGATGTTGAGGACATTTTAAaggAAATGACGTCAGCCGCAACACCATTGACAGCCATACCTCAAACACCAAGAAAGGAAATTGAGTCGAAATACACATTCAACACGAGTCtggtTGAAAATCCATCACCAACAAAGCCTCgtgagtaa
Protein Sequence: MGRPRVERDRLRERERQARAAMSVQAEQAAAGGAPDSRHGHHNHGHHADSHAATASLFRAPVKVNPDAQDRTTQQIQSKLGNYSVVRHLLEDPKRLIGIDGVPASPAPAHSSRLASSSGSSSRSSPSSQEFKKPGGPRSSSSSNSSSSSSSSHASAQRGGFVKPADGKPPYGGRGGYPGQPVKHGGNSNDHRSHGLLPAKGPPPPSNSSGSGNSNVGSSIANSNNNSSSNSSNSSSSSNSNRLHNAGSRLPRINLDNGINSRQTLEENTPDVEDILKEMTSAATPLTAIPQTPRKEIESKYTFNTSLVENPSPTKPRE

Sequence clustering based on sequence similarity using MMseqs2