Lsin019553.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Leptidea sinapis
Gene Symbol
Btbd3
Assembly
GCA_905404315.1
Location
FR990173.1:1525001-1537976[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.2e-26 1.8e-23 83.9 0.0 4 109 168 274 166 275 0.94
2 2 2 1.1e+03 0.9 0.0 76 108 273 305 272 307 0.85

Sequence Information

Coding Sequence
ATGAGGGGTAAAGTTGTTACACTGCCGCACAAGTTACCTGTTGTCCTCGGAAGGATTTTCCTGCGTTGGGTGTTCACTAAAGCTGGTTTAGTGCTTTTCGTCTACCGTGTAGTTTGGTATGCATTTAACACCCGGTCATCAATGAATGCTAGCGTAGATTTTTTTGAAAGTCTTATCGATGAAGACGGGCGGTTTTCCGAAGTGAATACGTGCCAAGAACCTTCACAGCGAGTTCATCGCCAAAGGATCAGTATTCAGAGGATTCGACCACAAAATTTACAAGctGAAAATATCAATAATGCTGGAGGACTGTCACCACCTAATACGATATCGCAAAGGGAGAGGGGAACACAAGTGTCTCAGTGCTACAGTGTGCCTTCTTCGCCATGTGGCTCAACCAGTTCAACACCCTCACCGACTGTGTCCTCAATACCCGGAACAGCAACTCATGATCCTGATTGGCAGGCAACAAAAACCACCATTCGAGACAGAAATGCTGCCATGTTCAACAATCAATTAATGGCTGATGTGACCTTTGTTGTAGGTCCACCAGGACACACACAAGTGATTCCagcacacaaatatgttttggCAACTGGCAGTTCAGTGTTCTATGCTATGTTTTATGGTGGCTTGGCTGAAAGTAAACAAGATATTGAAGTTCCCGATGTTGATCCTTCAGCATTCCTCACCTTACTGAAATATTTATACTGTGATGAAATCCAACTAGAAGCTGACAATGTTTTATCAACCCTCTATGTTGCCAAAAAGTATTTTGTACCACATGTTGCAAGAGCCTGTGTCAATTATCTAGAGACAAGTCTAACAGCTAAGAATGTCTGTCTACTTTTAAGTCAATCACGTTTTTTTGAAGAGCCAGAACTGATGAACAGATGCTGGGAAGTAATTGATGCACAGGCAGAAATGGCACTCACATCTGATGGATTTGTCGACATTGATGTATCTACTTTAGAGTCTGTGTTAGAAAGAGAGACTTTGAATTGCaaagaaattaatttgtttGAAGCAGCTTTATCATGGGCTAAAGCTGAATGTGTGCGTAGAGAAATAGAACCTACACCTTCAAATAAAAGAGCCATGCTAGGAAGTGCTATTCATCTGATACGATTCCCAACAATGACCTTGGAGGAATTTGCTAACAGTGCTGCTCAGCTTGGAATACTGACTCCACAAGAaactatagatatatttttacacTTCACTGCCTCAACTAAACCACAACTATCATATCCTGTCAAAGCGAGGACTGGTCTTAAGGCACAGATATGTCACCGATTTCAGTCATGTGCATATAGGAGTAACCAATGGAGATACCGGGGAAGGTGTGACTCAATACAATTCTGTGTCGATAAAAGGATTTTTGTTGTTGGCTTTGGCTTGTATGGATCCTCAAACGGTGCAGCTGATTACAATGTAAAGATAGAATTAAAACGTGTGGGAATAGTTCTGGCAGAAAACAACACAAAATTCTTTTCCGATGGATCGAGCAGTACattccatgtttattttgaaaatcCAATTCAAATTGAACCTGATTGCCTTTATACTGCATCGGCCATTCTAGATGGAAGTGAATTAAGTTATTTCGGACAAGATGGCTTAAGTGAAGTTTACATGGGCACTGTTACATTCCAATTTCACTGTTCTTCTGAAAGTACAAACGGCACTGGTGTCCAGGGTGGCCAAATTCCAGAACTAATTTACTACGGACCAACAGTTAACACTGCTGTAAATACAAGCACGGAAGAGGACTGA
Protein Sequence
MRGKVVTLPHKLPVVLGRIFLRWVFTKAGLVLFVYRVVWYAFNTRSSMNASVDFFESLIDEDGRFSEVNTCQEPSQRVHRQRISIQRIRPQNLQAENINNAGGLSPPNTISQRERGTQVSQCYSVPSSPCGSTSSTPSPTVSSIPGTATHDPDWQATKTTIRDRNAAMFNNQLMADVTFVVGPPGHTQVIPAHKYVLATGSSVFYAMFYGGLAESKQDIEVPDVDPSAFLTLLKYLYCDEIQLEADNVLSTLYVAKKYFVPHVARACVNYLETSLTAKNVCLLLSQSRFFEEPELMNRCWEVIDAQAEMALTSDGFVDIDVSTLESVLERETLNCKEINLFEAALSWAKAECVRREIEPTPSNKRAMLGSAIHLIRFPTMTLEEFANSAAQLGILTPQETIDIFLHFTASTKPQLSYPVKARTGLKAQICHRFQSCAYRSNQWRYRGRCDSIQFCVDKRIFVVGFGLYGSSNGAADYNVKIELKRVGIVLAENNTKFFSDGSSSTFHVYFENPIQIEPDCLYTASAILDGSELSYFGQDGLSEVYMGTVTFQFHCSSESTNGTGVQGGQIPELIYYGPTVNTAVNTSTEED*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00874595; iTF_00875443; iTF_01402818; iTF_01142498; iTF_01146407; iTF_01148199; iTF_01141033; iTF_00958060; iTF_01143214; iTF_01144658; iTF_01149714; iTF_01140309; iTF_01145367; iTF_01141790; iTF_01143936; iTF_01147488;
90% Identity
iTF_00874595; iTF_00875443;
80% Identity
iTF_00875443;