Ljuv001962.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Leptidea juvernica
Gene Symbol
MBD-R2
Assembly
GCA_949711685.1
Location
CATIXL010000002.1:15653716-15682570[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5.4 3.4e+04 -4.2 0.0 35 48 380 393 375 394 0.84
2 2 2.5e-15 1.6e-11 44.9 0.0 5 68 756 823 752 831 0.82

Sequence Information

Coding Sequence
ATGACTAGAAACTGCTGTATAGAAAACTGTAACTCTTCATCATTACGAGCTGAGGATTTTGGCGTTACATACCACAAATTTCCAAAAGACCCCATATTACGCAACACTTGGATTGAAGTCACACACACCCTTGCCAATGTAGAGTTCCCTGGTTTTGTATGTTCGAgacatttttgtaaaaaagactttaaaatatatcaagATTCAAAATATATTCTGATACCAGGTGCAGTACCATCAATATTTTCTTGGAAAATGGCTGATATTGGGGATAGTAGTAGTCCTCATGATATTTTTGAATGTGACAAAAATGAAGATAAGAATACATCCTCTAGCAGCAAAGATTCAGAACCAGAAAACATAGATAAGATTCAAAAGTTTATAGATGAGCAGCATCATAATTTAAAACCAGATAAAGACAATGTAGAAGCTGAGCTCAGTGTTTTGAGCCTTACAAATGAACAAACTGAAAATATGAATGGTGTTGTTAGTATGATGCTGACAGAACCAGAGACAGGTCCTACTGATGCTGATATAAAAGATAACATACCTGGGAAAGAGATTGAAAAATGTACTATTGCTCTTACCGTTGGATCTAAGGTTGAAGCCAGGGATTTTGCAGATATTTGGTACCCTGGAGAGATTGCTGAAGTAGATTATGATGAAATGGAAGTGCTGGTCCACtatgaaaatacttttaacaAgcATGATGAGTGGATAAATGTAAGCAGTTCAAGACTCAGGCCATATATTCCTAAACCTGAAAATTGTTTGAACTTACCAGAAATGGCTTCTACTAAAGGTTCACGTGATGAGAATACTATTCAAAAAGATGAAAGTAATGTAGAAGAAAATAATAAGGTGACCTTTATGCCTGGTGAGCGTTGCCTTGCTAGATGGCGTGATAATAGACGATTTATGGCCACAATAAATAAGGAGTTGGAAAATGGTGaatttgaaatagtgtttgaTGATGGTTTTCATTGGAAGTGTGCATCATCAAGGTTGTATAAGCTGAAAGATCCCTCCCTCTCAGTTGATACATCTACATCCACAAGTGTGTCTGCTTTGTCACCAATACCAGCTGGCACAGGTCCCATGGGAACACAGGGGTTAAATGTACCCTATCACACACATCTGTTTGATCCAACACGTGATTATTTAAGCTCGAAAAGCGAACGTCGCGAAATGAAAAGGAAATTGAATATcaaagaaatttttaatataggcCAAAAGAAAAGGAAAATTGTATCAAATTTCGAAAAAGAAAAAGGGAATGCTGAGACGAAGcctaaagtaattaaaaaacaaactaagAAGAAGATTGAGTCAGAAATGGAGATCAATAAGAAAACAGttgCTAAGATACATGACAACCAACAAACAACAACAAACAGTAcagatattaataatacatcTGAAACAGCAATGATTGAGGACTGTGACAAAATCAATCTACGTGATTTGGACATCGCAAGTGGTGATGATGACAAAATGCATACATCATATCTTTCAGATTCTTCAGATTTGAACAGTTCAACAGACCCCGTTACAAAAGAGGAAGAATGCTTGAAAAGGTTTGAGAAGCCTGATGAGATTAAACATGAAGaagaaattgttaaaataagaGAAGCAATCATGAGACTGGAGAGTAGTTTGAATACAACAGATTcagacaatattaaaataaaacaggaATTTGTAAAAGTAGAATCTTTTGATGTAGATACTTTGACTGACAATATTAAGGTAGAAAGTCTAGAACAATCAGAAGTAGACCTGGAAAAAGTAGAAATAACACTTGAGAAAGTAGAAACACCATTTGACCATGTAGCAATAAATGTagaaacatacaagaaacaGGCAAACGAAATAAGTCCTGAACAACTTATTGAGATGCAATCAAGTAACATAGAGGTAGTGAAAGTGGATTTAGGGAAACCGAAGCTAAAGAAAGAATCGTTGAAGTTGAAGAAGAGTAAGAATATGAGGTTGATGCGAGAGAAAAATGTTAAGCGAGAATTCGAGAGGGTTCAGAGCGAATTGATGGAGGTGAAGCGACAGATGGAAGAGATGCGACAGCAGATGTTATTGAAAACTGAATCAATTGCGCAAAGTGGTGGCACCAAGGAAATGGCAGAGAGTTTCCTGTTGCCTGGAGAGTGGTGCTGTAAGTGGGTAGATGGAGAACCAGTTGGTAAGGTGCGGGATTCTGCAGACAACAAACACGACGATAAAGTGCCGACGTTACCGCGCCGTAGTGTTgaggtTGAGGACAAAAGGTTACCAGTTGGATGGAAGAAACTTTTGGTTCGCAGAAGTTTGGGTCAGTCAGCTGGAAAATGGGATGTGGTTTTAGTCGCaccAGATAATAAAAAGATTCATACGAAGCATGAGATGCGTTTGTATCTAGAGTCAAACATGGATGACGCACTGAAACCTTACGAACCCGCGTTATTAGACTTCAGTGTTCACCAAAAACTATCGCGGCGCCTGGGCTGGGTTACATACTCCCAGGGGAATGAGAAGCCTTCTATGCCATACAGGAAGAGGAAACTATCGCTTGTACGTGATGGTAGATCTAAACAGAAACTCAATATTAGGAAACCGAAAGCTTTTTGTACACAACCTGGAGATGAACCAAGTAACACTAACATGTATGGTTCAGGTACGATGGATAATACTGCTACTACTACACTTGAAGACGGATATgTATATGTCGGGTCCCTGAAAGTACAAGTCAAAGATAATTTATTGTGTTGTCCCACTGAGGGTTGCTTTAAGAACTTCAGAAGTAGTGCACTACTGAAAATGCATATAAAACATTACCATAGAGAGTTGAAGGTAATGTTGGGTAAAGCTCCCAAAGTGGTGGACTTGGCCTACGCAAGATCCAAAGCCACACTTAAAGATAGGAAAAAGAAAAAGGCTGAACGAGTCATTAAAGTGAAACTGCCGAAACAGAAAAGAAGCGAAGAGAAGTTcaattttaaagatataaataccGAGCTAAAACGAAATATAATTcaacaagaaaataatatacataagatTGGAGACTCCCCTAAACTCCGCCAAGCTTTGGTACCTAGACCGGTTAAAGGTCCCAAAGTATTGTTGCCAGTGAGAAAAGTGAAACCCAGGGTAGAGAAAAACATGGAAAACGAACTAACTAATGACGAAACTTCAGCAAATGACATGAGTGAAATTGACTTTGAGACAGCAATATCGACACACACAGTTACAAAAACATTACaatcttttaaaaatgataGGAACAGGTTATTTAGTAAAGCAGCCGTGAGCGAGGATGACGAATGGGCTGCGGCCAACTCGGATTTCGAGAGCAGATCCAGTTACCTGGGCTCGGAAACACCAGATTTTAGAACTAATAAAAAGATTGTTCCGCATCAGTTTGGCTCTTCCGAATCAAATGAAGAGCATAAGGACAGTGAAATGTATATGTATACTGagaCCGGAGAAAAGGTGAAGATAGAGCGCATGAAACGCGAAGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGACGGCCTCATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAACACGCGCTGTGTCACAACATACAGAGAGAGGCCGAGGTACCGGAGAAGTACACGTGCAGCATCTGCCTGAACCCGCGGCGCGGGCGTCGCTCCCAGCGGTTCGTGCACGACCAGGACCGGCTTAAGAAAAATCACCCTAAGCTGTATCTGTGGGCGAAAGACTGGGATAGCACGGAGCTGAATTTGACTAAGGACAGACTGAACTCGGATTATTCAGACTTGAACGTGATTATAAACAACATCGGCAAGGAGAATATGCCGCTCAAGACCGGCTTCGACCACGAGGACCTGCCCCTCACCACGGAGCTGGAGAGAATGTCCAATGGCCAAGGTGTGTGCGGGCCGCAGCCCGAGGCCGCCATAGAGAACAGCGCGTGTCGCGAGCGACTGCTGCAGCACGTGCAGCGCTGTCAGGCCCTCGTCGACGCCAGGCTCGACTCCATCGAGGCGCAGGTCGCGGAATTAGAATCTCAAGACCCGTCATTTGAAGACGACGAAACCGCGGACTTTTATCCCCGAACGAAGCAAACTATACAGATGCTGATGAGAGATCTCGATACTATGGAGGAGCTCGCCATCATAACGTAG
Protein Sequence
MTRNCCIENCNSSSLRAEDFGVTYHKFPKDPILRNTWIEVTHTLANVEFPGFVCSRHFCKKDFKIYQDSKYILIPGAVPSIFSWKMADIGDSSSPHDIFECDKNEDKNTSSSSKDSEPENIDKIQKFIDEQHHNLKPDKDNVEAELSVLSLTNEQTENMNGVVSMMLTEPETGPTDADIKDNIPGKEIEKCTIALTVGSKVEARDFADIWYPGEIAEVDYDEMEVLVHYENTFNKHDEWINVSSSRLRPYIPKPENCLNLPEMASTKGSRDENTIQKDESNVEENNKVTFMPGERCLARWRDNRRFMATINKELENGEFEIVFDDGFHWKCASSRLYKLKDPSLSVDTSTSTSVSALSPIPAGTGPMGTQGLNVPYHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKKRKIVSNFEKEKGNAETKPKVIKKQTKKKIESEMEINKKTVAKIHDNQQTTTNSTDINNTSETAMIEDCDKINLRDLDIASGDDDKMHTSYLSDSSDLNSSTDPVTKEEECLKRFEKPDEIKHEEEIVKIREAIMRLESSLNTTDSDNIKIKQEFVKVESFDVDTLTDNIKVESLEQSEVDLEKVEITLEKVETPFDHVAINVETYKKQANEISPEQLIEMQSSNIEVVKVDLGKPKLKKESLKLKKSKNMRLMREKNVKREFERVQSELMEVKRQMEEMRQQMLLKTESIAQSGGTKEMAESFLLPGEWCCKWVDGEPVGKVRDSADNKHDDKVPTLPRRSVEVEDKRLPVGWKKLLVRRSLGQSAGKWDVVLVAPDNKKIHTKHEMRLYLESNMDDALKPYEPALLDFSVHQKLSRRLGWVTYSQGNEKPSMPYRKRKLSLVRDGRSKQKLNIRKPKAFCTQPGDEPSNTNMYGSGTMDNTATTTLEDGYVYVGSLKVQVKDNLLCCPTEGCFKNFRSSALLKMHIKHYHRELKVMLGKAPKVVDLAYARSKATLKDRKKKKAERVIKVKLPKQKRSEEKFNFKDINTELKRNIIQQENNIHKIGDSPKLRQALVPRPVKGPKVLLPVRKVKPRVEKNMENELTNDETSANDMSEIDFETAISTHTVTKTLQSFKNDRNRLFSKAAVSEDDEWAAANSDFESRSSYLGSETPDFRTNKKIVPHQFGSSESNEEHKDSEMYMYTETGEKVKIERMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQREAEVPEKYTCSICLNPRRGRRSQRFVHDQDRLKKNHPKLYLWAKDWDSTELNLTKDRLNSDYSDLNVIINNIGKENMPLKTGFDHEDLPLTTELERMSNGQGVCGPQPEAAIENSACRERLLQHVQRCQALVDARLDSIEAQVAELESQDPSFEDDETADFYPRTKQTIQMLMRDLDTMEELAIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00876240;
90% Identity
iTF_00874531; iTF_00875325; iTF_00876189; iTF_00876240;
80% Identity
iTF_00874531;