Basic Information

Gene Symbol
-
Assembly
GCA_002313205.1
Location
NNCF01130859.1:59503-60675[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00051 0.024 14.6 2.2 6 23 1 18 1 18 0.99
2 10 7.4e-05 0.0035 17.3 0.6 1 23 24 46 24 46 0.98
3 10 5.8e-07 2.7e-05 23.9 4.0 1 23 52 74 52 74 0.99
4 10 6.2e-06 0.00029 20.7 1.7 1 23 80 102 80 102 0.99
5 10 0.19 8.9 6.6 0.3 15 23 110 118 106 118 0.91
6 10 0.00026 0.012 15.6 3.2 1 23 124 146 124 146 0.98
7 10 8.1e-06 0.00038 20.3 2.0 1 23 152 174 152 174 0.99
8 10 8.2e-07 3.9e-05 23.4 0.7 1 23 180 202 180 202 0.98
9 10 0.00047 0.022 14.8 4.4 1 23 208 230 208 230 0.99
10 10 4.3e-07 2e-05 24.3 4.6 1 23 236 258 236 258 0.99

Sequence Information

Coding Sequence
tgCAGAAAGTCGtttattcaaaaagttcatcTGGAAAAACATTGGCGAAGACATACTAAAGAGAAACCTTTCCAATGTctaatttgtaaatctttatttactgGAAGCAGTTCTCTTAAAAGGCACATTCTAATACATACCGGGGAGAAACCttttcagtgtgaaatttgtaatTCCACATTTAGCCAAAAATGTAATCTCTTGAGTCACATGCGAACACATACTGGtgtgaaaccatttcagtgtgaattgtgtgaaaaatcatttacaacatcATCCATTCTCAAGACGCACAGGCTAACACACACTGGGgtgaaaccatttcaaaatctTAAGAGGCACATGCTAACGCACTCTGAAGTAAAACCATTTAAGtgtgaaaaatgtgaaaagtCATTTAGTTTAAAAAGTATTCTACAAAATCACGCCCACACACATACTCGGGATAAatcttttcaatgtgaaatttgtcaaTCCTTATTTAGCCAAAGCCGTTATCTCAAGAAGCACATGCTTACGCATACAGGGGTGAAACCATTTGTCTgcgaaatatgtcaaaaatcatttaaaacatcaTCCATTCTAAAGACGCACATGCTAGTACACTCTGGGGAGAAACCATTTAAGTGTGacatatgtcaaaaatattttagtctaaAATGTATTCTCAAAAATCACATCCGTACACATACTCGGGAGAagccttttcaatgtgaaatttgtcaaTCCTCATTTAGCCAAAGCAGTCATCTTAACAAGCACAAACGAACACATTCTGGGGAGAAACCATCTAAGcgtaaa
Protein Sequence
CRKSFIQKVHLEKHWRRHTKEKPFQCLICKSLFTGSSSLKRHILIHTGEKPFQCEICNSTFSQKCNLLSHMRTHTGVKPFQCELCEKSFTTSSILKTHRLTHTGVKPFQNLKRHMLTHSEVKPFKCEKCEKSFSLKSILQNHAHTHTRDKSFQCEICQSLFSQSRYLKKHMLTHTGVKPFVCEICQKSFKTSSILKTHMLVHSGEKPFKCDICQKYFSLKCILKNHIRTHTREKPFQCEICQSSFSQSSHLNKHKRTHSGEKPSKRK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00872739;
90% Identity
iTF_00872739;
80% Identity
iTF_00872739;