Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.016 2.7e+02 1.7 0.3 26 37 120 131 109 142 0.72

2 5 0.018 3e+02 1.6 0.0 22 45 146 169 137 176 0.79

3 5 0.00011 1.8 8.7 0.1 22 46 174 198 167 200 0.89

4 5 8.9e-06 0.15 12.1 0.1 21 52 201 232 197 232 0.88

5 5 0.00047 8 6.6 0.0 21 48 229 256 227 260 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.016	2.7e+02	1.7	0.3	26	37	120	131	109	142	0.72
2	5	0.018	3e+02	1.6	0.0	22	45	146	169	137	176	0.79
3	5	0.00011	1.8	8.7	0.1	22	46	174	198	167	200	0.89
4	5	8.9e-06	0.15	12.1	0.1	21	52	201	232	197	232	0.88
5	5	0.00047	8	6.6	0.0	21	48	229	256	227	260	0.89

Coding Sequence: ATGGAAAGTGGTCAAGAAAGAGATTTCCAGACAAGTTTGGAACCTGATGTGATCATTAATCATGATCCAAGTGAAGATGAAGATgAAAATGGTTTGAAGAACAAAACGCCCTATTCGGTTTCAAACAACGGGATGCAATCAAACAAAACAGTCCCTCCAGACATATCCATAATTCCTTTATCGAAAAAACctcaaataaaaattcgaCTTTTCAACAAAGAATACTCACCGTCAAAAGACGATATTAAAGTACAAAGTAATTCCAGATCTCCACGTCAAACAGTAAGACTGGTTTCAAAAGACGAAGCAGAACGAGTCGGTGATACTTATGCTCGACGTAAATCCCTCCCTCTTGAAAAATGTCCTATTTGTAAGAAGTACTTCCGAAGGATGAAAAcacatttattaaaacatgAACAAGCTAATCGAAATCCAAACGATCCACTCACTTGTACATTTTGTATGAAAGGATTCAACACTCAAAGTAATTTACTTATACATATGAGAACACATACTGGAGATAAACCATACGTTTGTGAAGTATGTCATAAAGGGTTCGCTCAATCCTGTAATTTGGTTAATCATTTAAGAATACATACAGGAGAAAGACCGTTTAAATGTCCACATTGTGACAGAGCTTTCACACAGTCTGGAAATCTCAACAATCATATAAGACTACATACTGATGAAAAACCATTCAAATGCCATTTTTGCGATAAAGCGTTCGTTCAATCGGGAAATCTTAATTCGCATATTAGAAATAATCACAAGTTTGTAGAGGAAGTTGGGAATGATGATAGCAGCAAAACGAATGAGTTTAAATGCTAG
Protein Sequence: MESGQERDFQTSLEPDVIINHDPSEDEDENGLKNKTPYSVSNNGMQSNKTVPPDISIIPLSKKPQIKIRLFNKEYSPSKDDIKVQSNSRSPRQTVRLVSKDEAERVGDTYARRKSLPLEKCPICKKYFRRMKTHLLKHEQANRNPNDPLTCTFCMKGFNTQSNLLIHMRTHTGDKPYVCEVCHKGFAQSCNLVNHLRIHTGERPFKCPHCDRAFTQSGNLNNHIRLHTDEKPFKCHFCDKAFVQSGNLNSHIRNNHKFVEEVGNDDSSKTNEFKC

Sequence clustering based on sequence similarity using MMseqs2