Lzep006425.5
Basic Information
- Insect
- Lasioglossum zephyrum
- Gene Symbol
- FOXP1
- Assembly
- GCA_028455615.1
- Location
- CM052330.1:17942706-17965488[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 5.6 5.4e+03 -2.2 0.2 24 50 197 224 187 232 0.70 2 3 1.6e-29 1.5e-26 92.5 0.5 2 81 637 710 636 717 0.94 3 3 5.9e-06 0.0057 16.9 0.0 48 82 752 781 747 786 0.86
Sequence Information
- Coding Sequence
- ATGGTCCCGACGGCTAAGCGCTCGAATCGTTTCGACGACGCCAGGGGATTCTCTTCGACTATGTACAATATCGCTGTTCCGTCGGCGAATTTTTCTGACCGAGCAACTTCGCTGTTTGCAGCCTTGAAGCAGCAGCAACAACAACCTCGGGAAAGTGTTCCTTCGTCGAGGGATCGCGAGAATCGGGAAAGGGAGAGGCTGTCGGTTCGTAGCCGTGAGAACGCGAGACCGAACGAGATAGGTGGCAACTTGCCGGATCAACAGCAACAAGAGCTCACGATCGAGTACCAAAGCAATGGGAAGCTCAGTCCCGCTGGGCACGCAGTGACAACAGCACCCATGACCCAGCAAAAGCAGCCTATCATCACGCAACAATCGCAGCAGCCGAGTTCTGGGGCACCTGGTCCCCAACCGAGTCCCCATCAGAGTCCACAGGCCCCGCAGAGGGGTTCACCACCGAATCCTTCGCAGGGTCCTCCACCTGGAGGACCGCCAGGGGCACCACCCTCTCAGAATCCCTCGCAGATGATGCTCAGCCCGGTGAGCGGCATCCATCAGATGCAACAGCTCCTACAGCAACACATCCTCAGCCCCACCCAACTGCAGTCCTTCATGCAGCAGCACACGCTGTACCTGCAACAGCAGCAGCAGCAACAACACCATCAGGACTCGTCGGAGCACGCGTCGAACCAAGACCGATTCGGCTACTTCTCGTCCCTAAAAGACCATCAACACCAGTTCGCGGAGCTGGGCAGGAAGAAGCTGGAACAGGCGATACAGCAACTGCAGGAACAGTTGCAGCTGAATGTCATTCAGCAGACGCATCTGTTGCAAACCGCCGACAAGAAGAAGGCCTCTGCACCTCTCCAGCAACTGGCGCTGCATCAGCAACGTCTGATACAGCAACTGCAGATCACGCAGAGCCAGTATCTTCTTCAACAAGGCCTGGGTCTGCAGGGACACAACCCTTCTTCAGGTCTGCAAGCGGGCGAGGGTCTGCCGATATGGAAGACGGAAACACCGGAAGTCCCGGAATCCCACCAGAATTCCAACGTTTCGAAGGCCGGGAGCGGATTGAACGGATTTCTGAATTCGACAGTGTCGAGTCGCCGCTCGGAGATGAACGGCACCACACCGCTGGACGAAAAACCGTTGGACGTTTCATCGAACGACAAGACTCATCCCCTCTACGGTCATGGGGTCTGCAAGTGGCCGGGCTGTGAAGTAATCTGTGAAGACTATCAAGCATTCCTTAAACACTTGAACACCGAGCACACGCTGGACGACCGATCGACGGCGCAGGCCAGGGTTCAGATGCAAGTCGTCTCCCAGCTAGAGATACAGTTGCAGAAGGAACGGGACCGACTCACCGCCATGATGCACCACCTGCACGTGGCGAAACAAATGGCATCCCCGGAACCACCAAAGTCGTCCGAGTCGTCGACCGGCTCGAGTGTACCAAAGCTAAATCTGTCGACGGCGCTGATGAGCCAGCCGCCGCCAAACTTCAACGTCTCCCAAGTGTCCTCGGTGTCGATGGCATTGGTTTCGGCGGTGAGGTCGCCTGCAGGAGGACAACTACCACCACCTGCTGGCGCGCCGATGCCGCCCATTCCTAACATGTCGAACATGTCCGGAATGCCGCCGCTGCCGAACATGCCTGGTAGCATGCCCACGATGCCGACCCTGCCCAGCATTCCAGGGCCCATCAGGCGGCGAATCAGTGACAAATCCGCGGTCTCGATGGCAGGAGGACTGTATGACGAGGGCACTGTAAGGCGCAGAGTAGCCGTCGATAGATCTGGAATAGATGTTAACGAAGGGCTGCCCTACATGCTGGAGCGTGCTGGCCTTGACGTCCAACAAGAGATTCAACGAAATAGGGAATTTTACAAGAACGCAGACATCAGACCGCCGTTCACGTATGCATCATTGATCCGGCAGTCGATCATCGAGTCCCCGGAGAAACAGCTGACGCTGAACGAGATCTACAATTGGTTCCAGAACACGTTCTGCTACTTCCGGCGCAACGCGGCCACGTGGAAGAACGCAGTGCGACACAACCTGTCTCTCCACAAATGTTTCATGCGAGTCGAAAACGTGAAAGGCGCCGTATGGACGGTGGACGAAGTGGAGTTTTACAAGAGACGTAATCAACGCGCTTGCAGCACGATCGGGGGCCATTTACTAAATGTCTCTGGCCCGAGTCTAGTCTCGAATAACCCGGAAGCCGGATGCGGGATGCGCCAGTGCAGAAACGCGATCCGCACCAATCTATCATTGCACAAGTGTTTTGTGCGCTATGAGGACGACTTCGGGTCATTCTGGATGGTGGACGACGCCGAGTTCGTAAAGCGGCGGCATCTGTCCCGCGGCCGCCCCAGGAAATATGACCCAACCCCATCACCCACTCCACCCCACCTCTCCGCACAGGGTGTCCCGTCGAAGAGTCCAACCCTAACGCACAGCCCGACCATGTACGGTGAAGCTTTGAACGCCAATCTCCAGTATTTCCAGGCGGCCCTCGGGGACTCCAATATGGGTTTTCTAAACAACTCGATGTGCACGTCGACGACAACGAGCCCCGACAAGGAGCACGTGTTAGCCCACAACGACTTAATGTCACCGTTGGATGAACCAGCCGTGCACATAAAGCAAGAAGGCCAGAGCCCGGAAGGAATAAAACGGGAACTGGTCGACGCGCCGATGGAGCCGGAAGGTGAGGACGACCAGGTAGACGAGAGGGAATACCCGGAAAGTCACGGGCACGATTCGGGCCAAGACGAGGACATGGCGGAGGACCTGTCGATGGCGCCTGACATCATGACTCCAGAGGATCAGATGGAGGCGTAG
- Protein Sequence
- MVPTAKRSNRFDDARGFSSTMYNIAVPSANFSDRATSLFAALKQQQQQPRESVPSSRDRENRERERLSVRSRENARPNEIGGNLPDQQQQELTIEYQSNGKLSPAGHAVTTAPMTQQKQPIITQQSQQPSSGAPGPQPSPHQSPQAPQRGSPPNPSQGPPPGGPPGAPPSQNPSQMMLSPVSGIHQMQQLLQQHILSPTQLQSFMQQHTLYLQQQQQQQHHQDSSEHASNQDRFGYFSSLKDHQHQFAELGRKKLEQAIQQLQEQLQLNVIQQTHLLQTADKKKASAPLQQLALHQQRLIQQLQITQSQYLLQQGLGLQGHNPSSGLQAGEGLPIWKTETPEVPESHQNSNVSKAGSGLNGFLNSTVSSRRSEMNGTTPLDEKPLDVSSNDKTHPLYGHGVCKWPGCEVICEDYQAFLKHLNTEHTLDDRSTAQARVQMQVVSQLEIQLQKERDRLTAMMHHLHVAKQMASPEPPKSSESSTGSSVPKLNLSTALMSQPPPNFNVSQVSSVSMALVSAVRSPAGGQLPPPAGAPMPPIPNMSNMSGMPPLPNMPGSMPTMPTLPSIPGPIRRRISDKSAVSMAGGLYDEGTVRRRVAVDRSGIDVNEGLPYMLERAGLDVQQEIQRNREFYKNADIRPPFTYASLIRQSIIESPEKQLTLNEIYNWFQNTFCYFRRNAATWKNAVRHNLSLHKCFMRVENVKGAVWTVDEVEFYKRRNQRACSTIGGHLLNVSGPSLVSNNPEAGCGMRQCRNAIRTNLSLHKCFVRYEDDFGSFWMVDDAEFVKRRHLSRGRPRKYDPTPSPTPPHLSAQGVPSKSPTLTHSPTMYGEALNANLQYFQAALGDSNMGFLNNSMCTSTTTSPDKEHVLAHNDLMSPLDEPAVHIKQEGQSPEGIKRELVDAPMEPEGEDDQVDEREYPESHGHDSGQDEDMAEDLSMAPDIMTPEDQMEA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01168990;
- 90% Identity
- iTF_00861705; iTF_00865142; iTF_00762373; iTF_00763059; iTF_00864459; iTF_00863096;
- 80% Identity
- -