Basic Information

Insect: Lasioglossum oenotherae
Gene Symbol: foxo
Assembly: GCA_028455765.1
Location: CM052292.1:3014305-3020878[-]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.4e-09 1.4e-06 28.4 0.3 49 83 6 38 3 42 0.91

2 2 7.8 7.7e+03 -2.8 0.4 25 43 257 271 249 281 0.44

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.4e-09	1.4e-06	28.4	0.3	49	83	6	38	3	42	0.91
2	2	7.8	7.7e+03	-2.8	0.4	25	43	257	271	249	281	0.44

Sequence Information

Coding Sequence: ATGCAAATCAAAGTAAACTCCATAAGACACAACCTGTCGTTGCACAGCAGATTCATGCGAGTTCAGAACGAAGGCACCGGCAAGAGTTCTTGGTGGATGATCAACCGGGACGCGAAGCCTGGCAAGTCCTCGCGACGAAGGGCTATAACAATGGAGACCAGTAAAATGGACAGACGACGTACTCGCGTGAGGAAGAAAATCGAGGCGCTGCGAAATGGCAGATTGCAACCCGACGCGACACCTAGCCCGAGCAACAGCGTGAACGAGGGTCTTGATCATTTCCCCGATAGCCCTCTTCAACACGGAAGCGGCTTCCAGCTCTCCCCCGATTTCCGTCCTCGGGCTTTAAGCAACGACTCCTCCTGCGGTCGATTAAGTCCAATCCCGGTGCTTCCCGGGAAACCAGATTGGACACCTACGTACGCTTCCTCGTATAGCCCAGAACAATTAGCCGGTAGCTTTGCGGAAACGGTGAAACTGGAATCCTATCAAATGTATCAGACATCACCACCAAGCCACCAGCAGCAGACCGGACCGCCGCCATCTTATTACGAGACCCAGTATCAGAGAAGCAACAGCATTTCCACGCGATCGCCTTCGTTCGCTTTGCAACCAACGCCTCAAACCACGAGTCAGCAAAGATGCCCGATCCACGGTCTGCAACCGTGCGCTTGTCAAATGACCGCAAGTCCAGTGGCAGCAATGTCACCGTCGTACCAGCAGAGCGAGCCGAGTCCCACAGCTCTGGGCAATAGTCAACAGCAGACTCTGCAGTACATAATGCAGACGCAACAGTGCCAACAGCAACAACAGCAGCAGCAGCAACAACAACAGCAAAGCGTGCCGACGGGAGCTAGCCCACCTCAGACGCCAACACCGTGCGGGCCTACACCGAGCACAATGATGGGCCAGTTGATGGGAGCGTTGAATAGCTCCACGATCCTTGACGATTTGAATATCAACATCGAGTCGTTGCATGGTGGATTCGACTGCAACGTCGAGGAAGTGATCAAGCACGAGCTGTCAATGGACGGGACGCTGGACTTCAATTTCCAGCAGGGTGTGATGGGTACGACCGCGATCCAGGTGAGTGATCGCAATGTCGGGCAAAACGGCTCGGTGTCGCAGAGCAACATCGTCGGAGGAGCGACCGGGAACGGAAGCGCGGGTGTCTATGTAACCAGCAGCGCCGCGACCCCATCTGCACCACCTTCGTGGGTCCACTAG
Protein Sequence: MQIKVNSIRHNLSLHSRFMRVQNEGTGKSSWWMINRDAKPGKSSRRRAITMETSKMDRRRTRVRKKIEALRNGRLQPDATPSPSNSVNEGLDHFPDSPLQHGSGFQLSPDFRPRALSNDSSCGRLSPIPVLPGKPDWTPTYASSYSPEQLAGSFAETVKLESYQMYQTSPPSHQQQTGPPPSYYETQYQRSNSISTRSPSFALQPTPQTTSQQRCPIHGLQPCACQMTASPVAAMSPSYQQSEPSPTALGNSQQQTLQYIMQTQQCQQQQQQQQQQQQQSVPTGASPPQTPTPCGPTPSTMMGQLMGALNSSTILDDLNINIESLHGGFDCNVEEVIKHELSMDGTLDFNFQQGVMGTTAIQVSDRNVGQNGSVSQSNIVGGATGNGSAGVYVTSSAATPSAPPSWVH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01418833;
90% Identity: iTF_00762376;
80% Identity: -