Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.00066 0.46 11.9 0.0 4 32 111 142 109 146 0.91

2 3 1e-12 7.2e-10 40.3 0.2 54 109 148 203 142 204 0.94

3 3 1.5 1e+03 1.1 0.0 77 108 203 234 201 236 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.00066	0.46	11.9	0.0	4	32	111	142	109	146	0.91
2	3	1e-12	7.2e-10	40.3	0.2	54	109	148	203	142	204	0.94
3	3	1.5	1e+03	1.1	0.0	77	108	203	234	201	236	0.83

Coding Sequence: ATGTCAAATCTGTGTTCTAGAATCGTTTTAAAACCGCAAAAAAGGTTACAAGATAGTATAGACGGTATGTCTGTTGCACAAACAAACACTTGGATGAACGCAGAACACGTTAATAATGGTGGCGGAATATCAATGTCGCCTCCGCTTACGATATCACAAAGGGAATCGGCAACACAAGTGTCACAATGCTACAGTGGGCCCCCGTCACCGTGTGGCTCGTCGAGCTCTGCTTCATCGCCTACGGTCTCACCGGCCCCTCCGCCGGGCACCGCTACGATAGATCCAAACTGGCAGGCCACAAAACCCACAGTCCGGGAGAGGAATGCAGCTATGTTTAATAACCAGCTAATGGCTGATATTACCTTTATTGTTGGCAGCCCTGGACATACACAAATAATACCAGCACACAAGTATGTGTTAGCTACGGCAGCTCTGTGTTCTATGCAATTGCCAGATGTTGAACCTTCTGCTTTCTTGACGCTACTGAAATACCTTTACTGTGATGAAATACAATTAGAAGCGGATAATGTTTTGTCAACATTATATGTggcaaaaaaatacattgtaccACATTTAGCCAGAGCAtgtgttaattatttagaaacaaGTCTAACTGCGAAGAATGCATGCCTGCTACTTAGTCAGTCACGTTTGTTTGAGGAGCCAGAACTGATGCAAAGATGTTGGGAAGTGATTGATGCCCAGGCTGAGATGGCCCTTACATCAGAGGGGTTTGTAGATATTGACGTTTCTACTTTGGAATCTGTGTTAGCGCGGGAAACGTTAAATTGTAAGGAAATCAACCTTTTGAGGCCGCTCTTGCTTGGGCCCAAGCTGAATGCTTACGTCGCGAAATGGATGTCACACCAAGTAATAAACGTGCGATGCTGGGAACTGCAATATACTTGA
Protein Sequence: MSNLCSRIVLKPQKRLQDSIDGMSVAQTNTWMNAEHVNNGGGISMSPPLTISQRESATQVSQCYSGPPSPCGSSSSASSPTVSPAPPPGTATIDPNWQATKPTVRERNAAMFNNQLMADITFIVGSPGHTQIIPAHKYVLATAALCSMQLPDVEPSAFLTLLKYLYCDEIQLEADNVLSTLYVAKKYIVPHLARACVNYLETSLTAKNACLLLSQSRLFEEPELMQRCWEVIDAQAEMALTSEGFVDIDVSTLESVLARETLNCKEINLLRPLLLGPKLNAYVAKWMSHQVINVRCWELQYT

Sequence clustering based on sequence similarity using MMseqs2