Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.6e-17 4.7e-14 53.1 0.2 34 85 5 53 3 56 0.92

2 3 8.2 1.5e+04 -3.0 0.0 10 21 63 74 60 78 0.73

3 3 9.7 1.8e+04 -3.2 0.0 11 30 95 114 92 120 0.74

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.6e-17	4.7e-14	53.1	0.2	34	85	5	53	3	56	0.92
2	3	8.2	1.5e+04	-3.0	0.0	10	21	63	74	60	78	0.73
3	3	9.7	1.8e+04	-3.2	0.0	11	30	95	114	92	120	0.74

Coding Sequence: ATGCCATCGCCCGAGCATTTTCCCTATTACAAAAGCAACGATGACCGCTGGAAGAACTCGGTACGACATAACTTATCGATAAATCCGCATTTTCGTAAAGGATCAAAAGCACCACACGGAGCGGGTCATTTGTGGGCCATAGCAAGTCAAGATGAATCAAAGCCTCGCCAACTCTTCGACATTACTACCATCAGACAGGCCTTAAAGAACGAAGAGAACGTTTCTTTGAAATCCGATTCGCGACTGGTAACGATGGACGAGGTCGCGGCAGCAACGGCCAGCATCGCGCAAAACATCGAGGAGGACAACGTCGACACGATAACACTGGAGCATTGCGCCGAGCAAATTCTGAGCGGCATCAAGAGAGAGGTCGAAGTGCAATATCTTGTACCGATGATGATATCGAGTAGCGGAGACGTAATTAATAATCAGCAGTGCCATCAAAGCGAGCCATCGGAGCATCCTGTCAAAGAAACAGACTTCTTAAATCCCGTTTCTAAGGAAGTGGTAGCCGAGGAGTGCGGCCTGATAAGCGAAGGCTACTTGGTAACCGATTTGAATCCCTCGTCTCTGAGCCTCAACGTGACCGAGTCGGAGATTGTGACCGCGGACAACCTTTTCGGCGAAGAGCTGAGCTTTCAGTTTTACGAGTTCTCCTCTCCCTCGCAGCTCCAGTCGGCTTGA
Protein Sequence: MPSPEHFPYYKSNDDRWKNSVRHNLSINPHFRKGSKAPHGAGHLWAIASQDESKPRQLFDITTIRQALKNEENVSLKSDSRLVTMDEVAAATASIAQNIEEDNVDTITLEHCAEQILSGIKREVEVQYLVPMMISSSGDVINNQQCHQSEPSEHPVKETDFLNPVSKEVVAEECGLISEGYLVTDLNPSSLSLNVTESEIVTADNLFGEELSFQFYEFSSPSQLQSA

Sequence clustering based on sequence similarity using MMseqs2