Basic Information

Insect: Kallima inachus
Gene Symbol: gsb-n
Assembly: None
Location: HiC:11981115-11999228[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 6.9e-17 1.5e-13 51.2 1.4 29 65 1 37 1 41 0.90

2 2 0.04 86 3.4 0.2 110 125 35 47 31 47 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	6.9e-17	1.5e-13	51.2	1.4	29	65	1	37	1	41	0.90
2	2	0.04	86	3.4	0.2	110	125	35	47	31	47	0.82

Sequence Information

Coding Sequence: ATGGCGGCGGCGGGCGTGCGGCCTTGCGTCATCTCGCGTCAACTCCGCGTCTCGCACGGCTGCGTATCAAAAATTCTCAATAGATACCAGGAAGGCGTGTCGGACCCGCCCAGTATATCCTCGATCTCGCGGTTGCTTCGCGGTGGCGCCAGGGACTCGGACGGGAAGAAAGATTACAGCATCGACGGCATACTCGGAGGTCGAGGCTCAGATTCTTCAGACATAGAGTCCGAACCAGGTCTAACATTGAAGCGAAAGCAACGACGTTCCCGTACAACCTTCACAGGGGAACAATTGGATGCGTTGGAAAGAGCCTTCCATAGAACCCAGTATCCAGATGTATACACAAGAGAGGAGTTGGCGCTACAAACCGGTCTTACTGAAGCCAGAATACAGGTGTGGTTTTCTAATAGACGAGCTCGACTGAGAAAAAACACGGGCTCAAACTCGACGCCAACACTTGCAAGTTACTCGACGTTACCAATGCCTCAAATACCCTGTCCTTATCCTGCAGGCGAAATACCTCCTTTATCCCAACACCATCCCCAGCACCCAGATCCCTGGCATCACCAAAAATACGCTAACTATAACCAATTAATGGCACAGTCTCAACATTTGAATCAAGCATTTCAAACAGCTTCTTTTCCTAGCTCATCAGGTGCTACTTTTAGCCACCTGGTTTCTGGTGCCAGTGCACCTTCTCATAGCCAGATTTTGGATACCAATGCTGCAAGAAGTGACTATGCACGATACCCACCTAATGACATTTACAACAAAACTATCAACTATATGCCCAAAGATTCTGAAGCAGGTGACAAAATTGTTAGCGACGAAGTCATAGAACAGAGAGACGACGCTTACGTTAAAGCAACTGGAAATGAATATAAAGATTTACAGAACAGTGATTATCCGAAAGTTCCTACTGATTACTCTAAGCTCACTGTGGACCCATCTTCATCTAATTGGAGCCCATCTAACAATACTTTGAACATGAGTCTAGCCGGACTATCTAGTGATTATAAATACATGAGTGATCCGTACTCATTCTCTAATATTGCTCCTGACCCTCTTAACCAACACAATTATACTAATCCAAGTAACGCAGCTAACAAGTACTGGATTTGA
Protein Sequence: MAAAGVRPCVISRQLRVSHGCVSKILNRYQEGVSDPPSISSISRLLRGGARDSDGKKDYSIDGILGGRGSDSSDIESEPGLTLKRKQRRSRTTFTGEQLDALERAFHRTQYPDVYTREELALQTGLTEARIQVWFSNRRARLRKNTGSNSTPTLASYSTLPMPQIPCPYPAGEIPPLSQHHPQHPDPWHHQKYANYNQLMAQSQHLNQAFQTASFPSSSGATFSHLVSGASAPSHSQILDTNAARSDYARYPPNDIYNKTINYMPKDSEAGDKIVSDEVIEQRDDAYVKATGNEYKDLQNSDYPKVPTDYSKLTVDPSSSNWSPSNNTLNMSLAGLSSDYKYMSDPYSFSNIAPDPLNQHNYTNPSNAANKYWI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00780883;
90% Identity: iTF_00985840;
80% Identity: iTF_00843343;