Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0034 9 7.4 0.1 27 56 3 31 1 33 0.85

2 6 0.00049 1.3 10.1 0.0 20 56 46 81 38 83 0.82

3 6 0.00024 0.64 11.1 0.0 20 56 96 131 88 133 0.82

4 6 0.00055 1.5 10.0 0.1 20 56 146 181 138 183 0.81

5 6 0.00055 1.5 10.0 0.0 20 56 196 231 187 233 0.82

6 6 0.00053 1.4 10.0 0.0 17 56 243 281 237 283 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0034	9	7.4	0.1	27	56	3	31	1	33	0.85
2	6	0.00049	1.3	10.1	0.0	20	56	46	81	38	83	0.82
3	6	0.00024	0.64	11.1	0.0	20	56	96	131	88	133	0.82
4	6	0.00055	1.5	10.0	0.1	20	56	146	181	138	183	0.81
5	6	0.00055	1.5	10.0	0.0	20	56	196	231	187	233	0.82
6	6	0.00053	1.4	10.0	0.0	17	56	243	281	237	283	0.82

Coding Sequence: ATGCGGTCGTGGTTGTGGTGCGCCGGGGCCGCGCTGGTGGCGGCGTGCGCGTGCGCAGCGCCCACCTACATCACCAGATACGACGACGTCGACCTCGACGACATCCTCGCCAGCGAGCGCCTCCTCACTGGCTACATCAACTCTCCCGAGATGCGGTCGTGGTTGTGGTGCACCGGGGCCGCGCTGGTGGCGGCGTGCGCGTGCGCAGCGCCCACCTACATCACCAGATACGACGACGTCGACCTCGACTACATCCTCGCCAGCGAGCGCCTCCTCACTGGCTACATCAACTCTCCCGAGATGTGGTCGTGGTTGTGGTGCACCGGGGCCGCGCTGGTGGCGGCGTGCGCGTGCGCAGCGCCCACCTACATCACCAGATACGACGACGTCGACCTCGACTACATCCTCGCCAGCGAGCGCCTCCTCACTGGCTACATCAACTCTCCCGAGATGCGGTCGTGGTTGTGCTGCACCGGGGCCGCGCTGGTGGCGGCGTGCGCGTGCGCAGCGCCCACCTACACCACCAGATACGACGACGTCGACCTCGACGACATCTTCGCCAGCGAGCGCCTCCTCACTGGCTACATCAACTCTCCCGAGATGCGGTCGTGGTTGTGGTGCGCCGGGGCCGCGCTGGTGGCGGCGTGCGCGTGCGCAGCGCCCACCTACACCACCAGATACGACGACGTCGACCTCAACGACATCCTCGCCAATGAGCGCCTCCTCACTGGCTACATCAACTCTCCCGAGATGCGGTCGTGGTTGTGGTGCGCCGGGGCCGCGCTGGTGGCGGCGTGCGCGTGCGCAGCGCCCACCTACACCACCAGATACGACGACGTCGACCTCGACGACATCCTCGCCAATGAGCGCCTCCTCACTGGCTACATCAAGTGCCTCATGGAGGAGGGGCCCTGCACTGCCGACGCCAGGGAACTCAGAAGTATGCCAAGTCGACATCTATAG
Protein Sequence: MRSWLWCAGAALVAACACAAPTYITRYDDVDLDDILASERLLTGYINSPEMRSWLWCTGAALVAACACAAPTYITRYDDVDLDYILASERLLTGYINSPEMWSWLWCTGAALVAACACAAPTYITRYDDVDLDYILASERLLTGYINSPEMRSWLCCTGAALVAACACAAPTYTTRYDDVDLDDIFASERLLTGYINSPEMRSWLWCAGAALVAACACAAPTYTTRYDDVDLNDILANERLLTGYINSPEMRSWLWCAGAALVAACACAAPTYTTRYDDVDLDDILANERLLTGYIKCLMEEGPCTADARELRSMPSRHL

Sequence clustering based on sequence similarity using MMseqs2