Basic Information

Gene Symbol
Poxn
Assembly
GCA_946894085.1
Location
CAMPPJ020000095.1:869330-888491[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 9.7e-42 3e-38 131.5 0.6 1 74 36 109 36 111 0.98
2 22 7.5e-14 2.4e-10 41.3 0.2 45 74 112 141 109 143 0.94
3 22 1.2e-14 3.9e-11 43.9 0.3 45 74 144 173 140 176 0.93
4 22 1.4e-14 4.4e-11 43.7 0.3 45 74 176 205 173 208 0.93
5 22 4.4e-13 1.4e-09 38.9 0.2 45 74 208 237 205 239 0.94
6 22 1.2e-14 3.9e-11 43.9 0.3 45 74 240 269 236 272 0.93
7 22 5.2e-13 1.6e-09 38.6 0.2 45 74 272 301 269 304 0.93
8 22 1.2e-14 3.9e-11 43.9 0.3 45 74 304 333 300 336 0.93
9 22 3.8e-13 1.2e-09 39.1 0.2 45 74 336 365 333 368 0.93
10 22 1.2e-14 3.9e-11 43.9 0.3 45 74 368 397 364 400 0.93
11 22 1.2e-14 3.9e-11 43.9 0.3 45 74 400 429 396 432 0.93
12 22 4.6e-13 1.4e-09 38.8 0.2 45 74 432 461 428 464 0.93
13 22 1.4e-14 4.4e-11 43.7 0.3 45 74 464 493 461 496 0.93
14 22 3.7e-13 1.2e-09 39.1 0.2 45 74 496 525 493 528 0.93
15 22 1.6e-14 5.1e-11 43.5 0.3 45 74 528 557 525 559 0.94
16 22 1.4e-14 4.5e-11 43.7 0.3 45 74 560 589 556 591 0.93
17 22 3.7e-13 1.2e-09 39.1 0.2 45 74 592 621 589 624 0.93
18 22 1.2e-14 3.9e-11 43.9 0.3 45 74 624 653 620 656 0.93
19 22 6.1e-13 1.9e-09 38.4 0.2 45 74 656 685 653 687 0.94
20 22 2.5e-13 7.8e-10 39.7 0.2 45 72 688 715 684 725 0.91
21 22 1.4 4.5e+03 -1.6 0.0 23 61 857 896 850 901 0.82
22 22 2.1e-05 0.066 14.1 0.0 39 74 1008 1037 990 1047 0.80

Sequence Information

Coding Sequence
ATGCCTGCGCCAACACGTCACTCGAGCAAAACTATCCTCGGCCCCTGTGGTAAATTACCTCGCGGGTTAACAGGAAACGTCTCAGTGAATGTACGTTTGCCGGCAGGTCAAGCGGGCGTCAATCAGCTCGGCGGCGTGTTCGTGAACGGTCGGCCGCTGCCGGACGTGGTACGCCGGCGCATCGTGGAGCTCGCCCTCCACGGCGTGAGACCCTGCGACATCAGCCGGCAGCTGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTCTCGGACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTCTCGGACGGCTGCGTCTCCAATATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTATCGGACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCAGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTCTCGGACGGCTGCGTCTCCAATATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTTTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTATCGGACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCAGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTCTCGGACGGCTGCGTCTCCAATATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTTTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTCTCGGACGGCTGCGTCTCCAATATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCGGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTACGAGACCGGCTCCATCCGGCCCGGCTCCATTGGTGGCAGCAAGACTAAGACGCTCGTATCGGACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTATGAGACCGGCTCCATCCGTCCCGGCTCCATCAGCGGCAGCAAGACCAAGACGCTCGTCTCGCACGGCTGCGTCTCCAAGATCCTCACCCGCTTCTACGAGACCGGCTCCATCCGGCCCGGCTCCATCGGCGGCAGTGTGACGTTCGACCGGAACCCTCGCTTTTGCGGCGGCTCCGTCCGCGTCATCACGCATGGTGGGTGCACGCGCGTGCGGTGCGGCGCGCGGGGCGTCGGCTCAGAGCAGCGGCGCCGGCGTGTCGGCCGCGTCGTCAACGCCGGCCGACGGCGTGGCGGCGTGGCTCAGCGCTGCTCGGCGCGGGGCGCATCGGCGCGGCTGCGCGGATGGCCGGCCAGCGTGCTCGGCTACCTCGCCGCGTCGCTGTCGGCGACGGCGACCCATCGGCGAGTCGTGCCTCGGGTGAACGGAAGACATAACTGGGGCCCACTTGCGGAAGATCAGACATCACCTTGCAGTGGCCGTCCAGACCCTCGAAGGCGCGAGCCGGACGACCGGTGCGGGAGCGGGCCGCTCCAGACGACTTCCGCTGTGACGCGAACGGAACGAGACGAATCGATTTCGGTGGCGTTCGCCAGCGTGCGCGCCGCCGTGATCGCGTCGCGTGTCCGAACGGCCGAGCAGTACATAGCTCGGTTTGGAGTGGGGCGCAAAATAGAAACAGGATTCCTAGTCCTGCTCGTCCCCGAACCAGTGGATGCCAGTGTGACGTTCGACCGGAACCCTCGCTTTTGCGGCGGCTCCGTCCGCGTCATCACGCGCCACCACTCCAAATTAAATCATGGTGGGTGCACGCGCGTGCGGTGCGGCGCGCGGGGCGTCGGCTCAGAGCAGCGGCGCCGGCGTGTCGGCCGCGTCGTCAACGCCGGCCGACGGCGTGGCGGCGTGGCTCAGCGCTGCTCGGCGCGGGGCGCATCGGCGCGGCTGCGCGGATGGCCGGCCAGCGTGCTCGGCTACCTCGCCGCGTCGCTGTCGGCGACGGCGACCCATCGGCGAGTCGTGCCTCGGACGCTCGTCTCGCACTACTGGGTCTCCAAGATCCTCACCCGCTTCGACGAGACCGGCTCCATCGGCGGCAGCAAGACCAAGAGATTCTCCGTGCGGGCATCGTTCGCCATGGTCCTCCTCGGTCCGGCCGCCCCAGGTGCGTTTACGATCCGCGATGATGCCGCGCCGTAA
Protein Sequence
MPAPTRHSSKTILGPCGKLPRGLTGNVSVNVRLPAGQAGVNQLGGVFVNGRPLPDVVRRRIVELALHGVRPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSKILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSNILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSKILTRFYETGSIRPGSISGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSNILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSKILTRFYETGSIRPGSISGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSNILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSNILTRFYETGSIRPGSIGGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSKTKTLVSDGCVSKILTRFYETGSIRPGSISGSKTKTLVSHGCVSKILTRFYETGSIRPGSIGGSVTFDRNPRFCGGSVRVITHGGCTRVRCGARGVGSEQRRRRVGRVVNAGRRRGGVAQRCSARGASARLRGWPASVLGYLAASLSATATHRRVVPRVNGRHNWGPLAEDQTSPCSGRPDPRRREPDDRCGSGPLQTTSAVTRTERDESISVAFASVRAAVIASRVRTAEQYIARFGVGRKIETGFLVLLVPEPVDASVTFDRNPRFCGGSVRVITRHHSKLNHGGCTRVRCGARGVGSEQRRRRVGRVVNAGRRRGGVAQRCSARGASARLRGWPASVLGYLAASLSATATHRRVVPRTLVSHYWVSKILTRFDETGSIGGSKTKRFSVRASFAMVLLGPAAPGAFTIRDDAAP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-