Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0079 20 6.0 0.0 15 38 16 39 13 47 0.82

2 7 0.072 1.9e+02 3.0 0.0 17 33 64 80 60 90 0.80

3 7 0.27 7e+02 1.1 0.0 15 32 108 125 105 135 0.83

4 7 0.14 3.7e+02 2.0 0.0 18 33 157 172 152 182 0.78

5 7 0.27 7e+02 1.1 0.0 15 32 200 217 197 227 0.83

6 7 0.037 96 3.9 0.0 16 33 247 264 243 274 0.81

7 7 0.052 1.3e+02 3.4 0.0 16 32 293 309 289 313 0.84

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0079	20	6.0	15	38	16	39	13	47	0.82
2	7	0.072	1.9e+02	3.0	17	33	64	80	60	90	0.80
3	7	0.27	7e+02	1.1	15	32	108	125	105	135	0.83
4	7	0.14	3.7e+02	2.0	18	33	157	172	152	182	0.78
5	7	0.27	7e+02	1.1	15	32	200	217	197	227	0.83
6	7	0.037	96	3.9	16	33	247	264	243	274	0.81
7	7	0.052	1.3e+02	3.4	16	32	293	309	289	313	0.84

Coding Sequence: ATGGTTGCTAATTCCAATAGACTTCTTGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCTTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTCCATCTATCCTCCGATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTCCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTCCATCTATCCTCCGATACACTCCTGGCAGCCTATCGTGGATATGTTGCGTCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTCCATCTATCCTCCGATACACTCCTGGCGGCCTATCGTGGATATGTTGCATCTATCCTCCGATACACTCCTGGCAGCCTATCGTGGATATGTTCCATCTATCCTCCGATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTCCATCTATCCTCCGATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCAATACACTCCTGGCAGCCTATCGTGGATATGTTGCATCTATCCTCCGATACGGAATTATGTTTTGGGGCAATACGACGGACAAACAAAGTGTTTTTAA
Protein Sequence: MVANSNRLLAAYRGYVASILQYTPGSLSWICCIYLPIHSWQPIVDMLHLSSNTLLAAYRGYVPSILRYTPGSLSWICCIYPPIHSWQPIVDMFHLSSNTLLAAYRGYVASILQYTPGSLSWICSIYPPIHSWQPIVDMLRLSSNTLLAAYRGYVPSILRYTPGGLSWICCIYPPIHSWQPIVDMFHLSSDTLLAAYRGYVASILQYTPGSLSWICSIYPPIHSWQPIVDMLHLSSNTLLAAYRGYVASILQYTPGSLSWICCIYPPIHSWQPIVDMLHLSSNTLLAAYRGYVASILQYTPGSLSWICCIYPPIRNYVLGQYDGQTKCF

Sequence clustering based on sequence similarity using MMseqs2