Hrec001284.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Hyppa rectilinea
Gene Symbol
FOXL2
Assembly
GCA_951799385.1
Location
OX637300.1:19596214-19620683[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7e-41 1e-37 129.0 0.1 2 88 105 190 104 190 0.97

Sequence Information

Coding Sequence
ATGGGGTTATTCAAGCCCTTTTTCAATAGAGATGAGAACGGGTTCATGTTTCGGCTTAGTTCGCCGTACGACAATAGAATATGCCTTCAGGAAAGCAACGCGGATGCAGCGAATTCCCAAAGCGTCAAAGGAGAAGAAGAGCTATCGCGAGTATACCAAACCCTCTCATTACCAACACTTCCAAGAGACGATAACAATTCTAACAACAGcAACACTGAAACAAAGAGTAAATCTAAGTCAACGACCCCAGCAAGCCCAGGCAACTCCGAAATGAAGCCGCAGTCAACCACACCGACGTCGCAGGCGCTTACGAAGCCTCCGTACTCTTACGTTGCCCTCATCACGATGGCAATACAAAACAGCCAAACGAAACGCGCTACGCTAAGTGAAATTTACGCTTACATCACTAAGGAATTTCCATTTTTCGAGAAGAATAAGAAAGGGTGGCAGAATTCAATTCGGCATAATTTAAGTCTAAACGAATGTTTCATAAAAGTACCAAGAGAAGGTGGAGGCGAGCGTAAGGGAAATTATTGGACCCTTGATCCTCAATGCGGCGAGATGTTCGAAAATGGGAACTTCAGGCGACGGCGGAGGATGAAGAGGCCATTTCGAGCCACCCCTTACTCCAAAACACTGTTCGGAGATGGGTATCACGTGGCACACGTCGGTCAACACGTACCCCCTCACATGCAGCCTCTGCCCCTCGGGGCCAGGAATTATTTCGGATCCGGTTCACCGTACCACCCACCTTCATACCCTCGATATGACACTACATGGCTAACGCAGTCGCCGAGCGGGCTGGGGTACGCAGGCGCGTGCGGAAGTATGGGACGCAGTCCACCCGGGTGTTCGCCACACAGCGCGCTGCCTCACCAGTCGTCGCCCGTCGCCGTCAATCCGTTTGCCACTCATCAAATTCAAGGACAGCTTCAGAGTCCTTTGCAGCCCATGCAGTCCATGTCGATGAATTCCTACAATGCTATTGGAGTCAGTGCTATAGACGGGTCTCCTAGCCCCGGTCCTGGTTATGCTCCTTCAACCGGAGGTTTTTCACCAAACAGACATCACGACATCGTCACGTCGTCGGACGCGGCTGTTACTCGATTTCCATTCTGGCCTGAAGGTGGATCCCCAAGTCCAAATCCAAGTTACGTGCAGTCTAGCAGTTTCTCGCCAACTCGCCGTCATGAGGCCGTCACTTCATCAGATGCAACGAGTGCTCGCTTCTCGTTCTGGCCCGAtggtgaatatttttttgtgtag
Protein Sequence
MGLFKPFFNRDENGFMFRLSSPYDNRICLQESNADAANSQSVKGEEELSRVYQTLSLPTLPRDDNNSNNSNTETKSKSKSTTPASPGNSEMKPQSTTPTSQALTKPPYSYVALITMAIQNSQTKRATLSEIYAYITKEFPFFEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPQCGEMFENGNFRRRRRMKRPFRATPYSKTLFGDGYHVAHVGQHVPPHMQPLPLGARNYFGSGSPYHPPSYPRYDTTWLTQSPSGLGYAGACGSMGRSPPGCSPHSALPHQSSPVAVNPFATHQIQGQLQSPLQPMQSMSMNSYNAIGVSAIDGSPSPGPGYAPSTGGFSPNRHHDIVTSSDAAVTRFPFWPEGGSPSPNPSYVQSSSFSPTRRHEAVTSSDATSARFSFWPDGEYFFV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01027105; iTF_00834434; iTF_00836329; iTF_00837277; iTF_00835358; iTF_00932226; iTF_01083106; iTF_00467268; iTF_00318691; iTF_00711619; iTF_01063555; iTF_01028068; iTF_00042437; iTF_00787429; iTF_01251557; iTF_00888998; iTF_00007815; iTF_00236456; iTF_00235681; iTF_01489949; iTF_00809864; iTF_00049705; iTF_00273417; iTF_00274253; iTF_00808909; iTF_00428809; iTF_00819865; iTF_00818958; iTF_01429742; iTF_00446922; iTF_01135562; iTF_00342021; iTF_00441292; iTF_00822693; iTF_01501893; iTF_00908620; iTF_00404501; iTF_00706751; iTF_00017985; iTF_01360417; iTF_00736428; iTF_00432941; iTF_00794126; iTF_00176913; iTF_00121202; iTF_01424852; iTF_00821583; iTF_00951599; iTF_00973526; iTF_00952510; iTF_00354896; iTF_00785008; iTF_01538545; iTF_00928464; iTF_00122162; iTF_00444914; iTF_01192436; iTF_00383434; iTF_01362900; iTF_00157009; iTF_00017150; iTF_00648917; iTF_00649834; iTF_01172138; iTF_00390188; iTF_01207917; iTF_00818166; iTF_00790049; iTF_01076194; iTF_00826632; iTF_00033629; iTF_00032714; iTF_00205868; iTF_00142901; iTF_00685237; iTF_00708983; iTF_01061688; iTF_01064440; iTF_01124408; iTF_00076260; iTF_01125252; iTF_00075266; iTF_00074285; iTF_01302096; iTF_00006099; iTF_01281114; iTF_01282030; iTF_01279072; iTF_01502782; iTF_01443640; iTF_01439701; iTF_00035449; iTF_00284334; iTF_00637284; iTF_01332353; iTF_01166403; iTF_00677348; iTF_00280938; iTF_00636078; iTF_00325177; iTF_00341145; iTF_00345625; iTF_00757945; iTF_00120295; iTF_00123156; iTF_00761433; iTF_01436825; iTF_00667162; iTF_01197530; iTF_01440794; iTF_00063387; iTF_01358696; iTF_00000124; iTF_00000989; iTF_01151870; iTF_01220462; iTF_00276082; iTF_01010175; iTF_01062559; iTF_00771680; iTF_00783232; iTF_00785823; iTF_00791008;
90% Identity
iTF_01084057;
80% Identity
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