Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.8 8e+03 -3.0 2.7 57 65 5 13 1 24 0.68

2 5 0.55 2.4e+03 -1.3 3.4 41 61 46 65 34 73 0.73

3 5 2 8.5e+03 -3.0 0.0 12 28 82 98 79 98 0.70

4 5 3.7e-15 1.6e-11 44.1 6.0 2 70 101 168 100 168 0.93

5 5 0.04 1.7e+02 2.4 0.2 2 14 170 182 169 189 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.8	8e+03	-3.0	2.7	57	65	5	13	1	24	0.68
2	5	0.55	2.4e+03	-1.3	3.4	41	61	46	65	34	73	0.73
3	5	2	8.5e+03	-3.0	0.0	12	28	82	98	79	98	0.70
4	5	3.7e-15	1.6e-11	44.1	6.0	2	70	101	168	100	168	0.93
5	5	0.04	1.7e+02	2.4	0.2	2	14	170	182	169	189	0.80

Coding Sequence: ATGGACAAGTGCCTGATATGTCAAATATGCGGAAAAGAGCTTCCGTTTAATCCGAAATGTCCGTGCACCCTGGGGGGACATATGCTAAGGAAACATCCTCAAGTGATAATGACACATTTCTCCAAGGAGAATTTGCTTTGTTGCTGTAGCAGTACTAGATCATCTGAGAATAAATTCAAACACCCTTGTCCGAAAACTGGACTGCCATGCCGTTGTGCCATTAATGAACCACCTCcttctattaataaaaaaattcgtcCCAGATGCAAGTTTGAAACTTCAgTTGAAACATGGAAACCTGGTCCGTTAAGAGTTATCTGCCCACATTGCTTTAATATAGACCGACCCTGTATCCGAATACAACGAAACAGAGTGGCTCATTTCCCACTTGGAGCTCTATGCCTTTTAGTATGTTGGCCTATTTGTTTCATGCCATTTATGATGTCCCAAACGCAAATTTCACTATTTTGCAAGAAATGTGGTGCGTTTTTAGGAGAATATGATCAAAAATCAGGTCATATGAAATGTCCTCCATGTGCGGCTCAAGGAGATATTAATGTACCTTCAGAGTGCTAA
Protein Sequence: MDKCLICQICGKELPFNPKCPCTLGGHMLRKHPQVIMTHFSKENLLCCCSSTRSSENKFKHPCPKTGLPCRCAINEPPPSINKKIRPRCKFETSVETWKPGPLRVICPHCFNIDRPCIRIQRNRVAHFPLGALCLLVCWPICFMPFMMSQTQISLFCKKCGAFLGEYDQKSGHMKCPPCAAQGDINVPSEC

Sequence clustering based on sequence similarity using MMseqs2