Basic Information

Insect: Hypomecis punctinalis
Gene Symbol: Runx3
Assembly: GCA_949316475.1
Location: OX438814.1:14838746-14839264[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.8e-52 3e-48 164.0 0.0 3 95 50 142 48 167 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.8e-52	3e-48	164.0	0.0	3	95	50	142	48	167	0.94

Sequence Information

Coding Sequence: ATGTGCAGCACGCAGCGCGCCCGGGTGTCGAGGATGCACCTAACGGGCGCGACGAGTGGCGCTGTGTCGCCTGACACGAGCTCGACGCTGCTCCACGAGACTTACACCAAGATGACGTCGGACATCCTCGCGGAGCGGACTCTTGGGGACTTTCTGTCGGAGCACCCGGGGGAGCTGGTGCGGACAGGCAGCCCGCACTTCGTGTGCACGGTGCTGCCTCCTCACTGGCGGTCGAATAAGACGTTACCGGTCGCGTTCAAAGTGGTCGCTCTGGGTGACATTGGCGACGGTACGCTAGTGACCGTGCGCGCGGGGAATGATGAGAACTGCTGCGCTGAGCTGAGGAACAGTTCAGCGGTGATGAAGAACCAGGTGGCCAAGTTCAACGACTTGAGGTTCGTCGGCCGCAGCGGTCGCGGTGAGTGCCGAAGGTGCAGTTTTGTGACATGTTGTTTCATGTTATTATCCCTTACTGTGAATGTGAAAAATCAATCTGCCAGGAATATCTATAACACTTAA
Protein Sequence: MCSTQRARVSRMHLTGATSGAVSPDTSSTLLHETYTKMTSDILAERTLGDFLSEHPGELVRTGSPHFVCTVLPPHWRSNKTLPVAFKVVALGDIGDGTLVTVRAGNDENCCAELRNSSAVMKNQVAKFNDLRFVGRSGRGECRRCSFVTCCFMLLSLTVNVKNQSARNIYNT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00825356; iTF_00935457; iTF_00149154; iTF_00462148; iTF_00148261; iTF_00341991; iTF_00772653; iTF_00155087; iTF_01145077; iTF_00156027; iTF_01134559; iTF_00681443; iTF_00236424; iTF_00071187; iTF_00121171; iTF_01333503; iTF_00699875; iTF_00705763; iTF_01161092; iTF_00701736; iTF_00696281; iTF_01387395; iTF_00017953; iTF_00317889; iTF_00682145; iTF_00715585; iTF_00783201; iTF_00806465; iTF_00952481; iTF_01020961; iTF_01027073; iTF_01076161; iTF_01279041; iTF_01532801; iTF_01545537; iTF_00383394; iTF_00677314; iTF_00737250; iTF_00771650; iTF_00824482; iTF_00859234; iTF_00925506; iTF_01028034; iTF_01331202; iTF_01362274; iTF_01463938; iTF_01507842; iTF_00038467; iTF_00075235; iTF_00147075; iTF_00166723; iTF_00431907; iTF_00711587; iTF_01063523; iTF_01078851; iTF_01148611; iTF_01491651; iTF_00008676; iTF_00076228; iTF_00787396; iTF_00836292; iTF_00907652; iTF_00960708; iTF_01115492; iTF_01316100; iTF_00447941; iTF_00642117; iTF_00822661; iTF_00851493; iTF_01125221; iTF_01359493; iTF_01501861; iTF_01534565; iTF_00410054; iTF_00832678; iTF_00954182; iTF_01157446; iTF_00042407; iTF_00213191; iTF_00357191; iTF_00467239; iTF_00674087; iTF_00957735; iTF_01029927; iTF_01077959; iTF_01092839; iTF_01358663; iTF_01495559; iTF_00278888; iTF_00419560; iTF_00428776; iTF_00659240; iTF_00680296; iTF_00888968; iTF_00913384; iTF_00985768; iTF_01246600; iTF_01285320; iTF_01525704; iTF_01526792; iTF_00120265; iTF_00124009; iTF_00409065; iTF_00412297; iTF_00778569; iTF_00809833; iTF_01171241; iTF_01219561; iTF_00162282; iTF_00280906; iTF_00290442; iTF_00382346; iTF_00446890; iTF_00666282; iTF_00801578; iTF_01170346; iTF_01172106; iTF_01341994; iTF_01361354; iTF_01503626; iTF_00204907; iTF_00212203; iTF_00247819; iTF_00796299; iTF_00818923; iTF_00908587; iTF_01091467; iTF_01140011; iTF_01154795; iTF_01192395; iTF_00074252; iTF_00205836; iTF_00284300; iTF_00736396; iTF_00784172; iTF_01075148; iTF_01140716; iTF_01494092; iTF_01560908; iTF_00352813; iTF_00432909; iTF_00726061; iTF_00780813; iTF_01142189; iTF_01182445; iTF_01281997; iTF_01438669; iTF_01451245; iTF_01542733; iTF_00036398; iTF_00274222; iTF_00636046; iTF_00774286; iTF_00782414; iTF_00786542; iTF_00924366; iTF_01084910; iTF_01119054; iTF_01230286; iTF_01429710; iTF_01437742; iTF_01452110; iTF_00037551; iTF_00039567; iTF_00072047; iTF_00156975; iTF_00323247; iTF_00662863; iTF_00784975; iTF_00843279; iTF_01116943; iTF_01259855; iTF_01264175; iTF_01496335; iTF_01569039; iTF_00027536; iTF_00111376; iTF_00124944; iTF_00266960; iTF_00300944; iTF_00373680; iTF_00407344; iTF_00660080; iTF_00794096; iTF_00821552; iTF_00858320; iTF_00928432; iTF_00951568; iTF_01081360; iTF_01094672; iTF_01207888; iTF_01533712; iTF_00122129; iTF_00795473; iTF_01141425; iTF_01152817; iTF_01367473; iTF_01544657; iTF_00249490; iTF_00301874; iTF_00364690; iTF_00874226; iTF_00906834; iTF_01025746; iTF_01071410; iTF_01118034; iTF_01141426; iTF_01175986; iTF_00006067; iTF_00034483; iTF_00256627; iTF_00444883; iTF_00777779; iTF_01084019; iTF_01502739; iTF_01546419; iTF_00022580; iTF_00114708; iTF_00206772; iTF_00299924; iTF_00345588; iTF_00461332; iTF_00673268; iTF_01079668; iTF_01093812; iTF_01339732; iTF_01439668; iTF_00404469; iTF_00656917; iTF_00685205; iTF_00695253; iTF_01221269; iTF_01338261; iTF_00043254; iTF_00123126; iTF_00810774; iTF_00875926; iTF_00887990; iTF_00930998; iTF_00947670; iTF_01208982; iTF_00040567; iTF_00341111; iTF_00708951; iTF_00745399; iTF_00869399; iTF_01016343; iTF_01424823; iTF_00035416; iTF_00425144; iTF_00448792; iTF_00622584; iTF_00658136; iTF_00942584; iTF_00973496; iTF_01064408; iTF_01281080; iTF_01335704; iTF_01402520; iTF_00119385; iTF_00144345; iTF_00237241; iTF_00632537; iTF_00662009; iTF_00710809; iTF_00722809; iTF_00757913; iTF_00775833; iTF_00856377; iTF_01133497; iTF_01197497; iTF_01463033; iTF_00185914; iTF_00282042; iTF_00289402; iTF_00363802; iTF_00751802; iTF_00837242; iTF_01543674; iTF_00026619; iTF_00637243; iTF_00654011; iTF_00667131; iTF_01030907; iTF_01080507; iTF_01156059; iTF_00021116; iTF_00063356; iTF_00830940; iTF_00835324; iTF_01166364; iTF_01428828; iTF_01440764; iTF_01531740; iTF_00185085; iTF_00287837; iTF_00457021; iTF_00457789; iTF_00638429; iTF_00683101; iTF_01158493; iTF_01360381; iTF_01435837; iTF_01489917; iTF_00025054; iTF_00177854; iTF_00180222; iTF_00353854; iTF_00770878; iTF_01019998; iTF_01317054; iTF_01377246; iTF_01506942; iTF_00000959; iTF_00017119; iTF_00197151; iTF_00374943; iTF_00655871; iTF_00661055; iTF_00781599; iTF_00905887; iTF_00932191; iTF_01028991; iTF_01090463; iTF_01340927; iTF_00277152; iTF_00441248; iTF_00775040; iTF_00779296; iTF_00781600; iTF_00834400; iTF_00850368; iTF_01153632; iTF_01386496; iTF_00649797; iTF_00875077; iTF_01017509; iTF_01018352; iTF_00055176; iTF_00687688; iTF_01041515; iTF_01415598; iTF_01425742; iTF_01509358; iTF_00354864; iTF_00967828; iTF_00172503; iTF_01332321; iTF_01538515; iTF_01436792; iTF_01033497; iTF_00390139; iTF_00405704; iTF_00186914; iTF_01178179; iTF_01204644; iTF_00689189; iTF_00777221; iTF_00207622; iTF_01139432; iTF_01202249; iTF_00197899; iTF_00700779; iTF_01203819; iTF_00702668; iTF_01500876; iTF_01203022; iTF_01245711; iTF_00072496; iTF_00077264; iTF_00150260; iTF_01336597; iTF_01403221; iTF_00208599; iTF_00704727; iTF_01145816; iTF_01528056; iTF_00818138; iTF_01279962; iTF_00250238; iTF_00744382; iTF_00355903; iTF_00703711; iTF_00445885; iTF_00706718;
90% Identity: iTF_00017953;
80% Identity: iTF_00895695;