Basic Information

Gene Symbol
Bcl11b
Assembly
GCA_964007245.1
Location
OZ023280.1:18995005-19014095[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 1 96 4.9 2.0 2 22 164 184 163 184 0.94
2 12 0.031 2.8 9.7 0.2 2 20 198 216 197 218 0.96
3 12 0.0039 0.36 12.6 1.3 1 23 259 281 259 281 0.98
4 12 0.38 35 6.3 0.4 2 20 383 401 382 403 0.89
5 12 0.00032 0.029 16.0 1.9 1 23 411 434 411 434 0.97
6 12 0.00048 0.044 15.4 1.9 1 23 456 478 456 478 0.98
7 12 1.9e-06 0.00017 23.0 2.1 1 23 485 507 485 507 0.98
8 12 5.4e-07 4.9e-05 24.7 1.7 3 23 521 541 519 541 0.96
9 12 1.1e-06 0.0001 23.7 0.5 1 23 547 569 547 569 0.99
10 12 5.9e-07 5.4e-05 24.6 2.5 2 23 576 597 575 597 0.96
11 12 2e-07 1.8e-05 26.1 1.5 1 23 603 625 603 625 0.99
12 12 1.1e-05 0.001 20.6 0.1 1 23 631 653 631 653 0.99

Sequence Information

Coding Sequence
ATGGCTGCTCACCATCACAAcaaagttgaaattaaaatcgaaaaattatgcCGCACTTGTCTATCGCGCGATAATGAATTGAATTCGTTATTCGATATTACTATTGGATCTGTGTCCCTGGATACAGTAGTAACTGCTATAACTGGGCTTAAGATCCGTAAAGGCGATGGGTTACCTTCCACAATATGTAGCGATTGCAAGGATAAAGCAGAAAAAGCTTATGATTTTAAAAAGAAGTCACAGGAAGCACACATTTCTTTAAGAGGCTTTTTCAAGAAAGACCACACGGTACTGCAGAAAACAGAAGATGTCAATATTAAAGagAAAAAGCCAATGGATGTCAAAACTGAACACTTTTCATATAATGACAATGATGATTTTTCTGATGCGGATTATAGTTTTCCGCTAAGTAATAATCCAGATGAGTCTAGTAATTTAGAAGTCAATGTGAAACATGAAGCATATAAAGAAGAAAATGTATCATACATGGAATGCAAGAAGTGTTGTTTGGTATTTGAAACTGCTAGTAAATTTGAagaacataaaagaaaaagatgTGTAAAAGTTGAATTTGAGGATGTGAATGGAACATATTGTCCGATTTGCGGCACTTGCTATGATGGGGACCAAAGTCTGTCCAAGCACATGTGGGAGTTCCATGCTGACTTGATGGGCCCCAAAAAAAGGGGACGGCCTAAAAAACTCATGACAACGacaATATTAAACAAACTGTCTGAAAATGGTCTACTAATTTCATCGAGACAAAAGAAGACATACCAGTGTTCCTTCTGTAAAGTCCAGACTAAAACCAAAGAAGATTTAAGTTCTCACATTTTGCAACATAAAGATTTAAAAGTGTTATGCTGTATTACATGcaagaaaatgtttttgaaaaagaAGTTTTTCAATTTCCATGCTTGCAACAGAAATTCCACGAATGCCATTGAAAATGATTCATCAAATACCCAAGGAGAAAAGAATGGGAAGTCTGCTTATTCCACAGAGATGCTTTTGCAGGATCTGTTTGACCCAAATGGTGATATGGCATTGTCTATGGTTCAAGCGTGTACAGCGTGCTCCGGCGTCTACCTTTCTGAAGCTGATCTCATCAACCACCACGACACCGAGCATCCAGAGCTCTCTCTTAGGTGTAACCATTGTACAAAGTTATTCGCATCAGTAAAAACAGCGGCGCGCCACAGATCCGTGTGCAAGCAGATTGAGAGAATGCACAAGTGTACCACATGCGGATTAAAGTTCGCGTACGAAATTTCTCTCAACAAACACATACTGCGATATCATCAGGGAGAAAGTGTCTCTGTTGCTTTCATGAGCCGTAAGCACAAAGTTGAAGAAAATGTACAGTATCAGTGCGACACGTGTCACAAGATGTTCCTTAGGAAAGATGCTCTTGCGAAGCACGCTAAGCTGCACATGCCAAATCAGAAGCTTTTTGAATGCGATGTCTGTCAAAAGAAGTTCAATCGCAGTGATAATTTACGAACCCACAAGAAGATACACGACGTGGACAGAGTTAAACCTCCGGCTAACAACTGCCTGTGCCTCTACTGCGGCCGAGGGTTCTCCAACTCTTCCAATCTGATCGTCCACATGCGCCGACATACTGGGGAGAAGCCATACAAATgcgacttttgccctaaagGTTTCCCGAGGTCATCAGATCTTTTGGTCCACAGAAGATCGCATACAGGCGAAAAACCGTGTGTATGCCGCATTTGTGGAAAAGcgTTCTCCCGTAGCAACAAGCTGTCGCGACACATGCGCGTCCACACGGGCCAGCGGCCTTACAAGTGCACGTACTGTGAGAAGGCATTCTCTCAGAGCAACGATCTGACTCTGCACATTCGGCGGCACACCGGCGACAAACCTTACGTGTGTGAAGTGTGCGGCGAGAGGTTCATACAGgGTACAGCTCTGCAGAACCACAGGCGGACGCACGGGCACtttccgccgccgccgccagaCCTGGCCTCCCTGACTAGCCAGGTCCAAGCCATCACCTACCCAGTCTCCAATATTTCCAACATCTCCAACATTAATCTACCACCACACGAGACTCACATGCCCAACTAG
Protein Sequence
MAAHHHNKVEIKIEKLCRTCLSRDNELNSLFDITIGSVSLDTVVTAITGLKIRKGDGLPSTICSDCKDKAEKAYDFKKKSQEAHISLRGFFKKDHTVLQKTEDVNIKEKKPMDVKTEHFSYNDNDDFSDADYSFPLSNNPDESSNLEVNVKHEAYKEENVSYMECKKCCLVFETASKFEEHKRKRCVKVEFEDVNGTYCPICGTCYDGDQSLSKHMWEFHADLMGPKKRGRPKKLMTTTILNKLSENGLLISSRQKKTYQCSFCKVQTKTKEDLSSHILQHKDLKVLCCITCKKMFLKKKFFNFHACNRNSTNAIENDSSNTQGEKNGKSAYSTEMLLQDLFDPNGDMALSMVQACTACSGVYLSEADLINHHDTEHPELSLRCNHCTKLFASVKTAARHRSVCKQIERMHKCTTCGLKFAYEISLNKHILRYHQGESVSVAFMSRKHKVEENVQYQCDTCHKMFLRKDALAKHAKLHMPNQKLFECDVCQKKFNRSDNLRTHKKIHDVDRVKPPANNCLCLYCGRGFSNSSNLIVHMRRHTGEKPYKCDFCPKGFPRSSDLLVHRRSHTGEKPCVCRICGKAFSRSNKLSRHMRVHTGQRPYKCTYCEKAFSQSNDLTLHIRRHTGDKPYVCEVCGERFIQGTALQNHRRTHGHFPPPPPDLASLTSQVQAITYPVSNISNISNINLPPHETHMPN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00044719;
90% Identity
iTF_00827255;
80% Identity
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