Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.14 8.9e+03 -1.6 1.4 52 78 44 70 15 102 0.52

2 4 0.12 7.5e+03 -1.4 0.4 42 84 97 139 76 160 0.60

3 4 0.0093 5.8e+02 2.3 2.8 195 267 162 233 128 251 0.73

4 4 1.3e-20 8e-16 60.9 9.5 1 42 259 300 259 304 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.14	8.9e+03	-1.6	1.4	52	78	44	70	15	102	0.52
2	4	0.12	7.5e+03	-1.4	0.4	42	84	97	139	76	160	0.60
3	4	0.0093	5.8e+02	2.3	2.8	195	267	162	233	128	251	0.73
4	4	1.3e-20	8e-16	60.9	9.5	1	42	259	300	259	304	0.95

Coding Sequence: ATGTCGACCTTGTGCCGAGCAGATAAGAATATGGGGAACTCTGCAGGAAACGAGGAGGTAAGGCATGAGGAAGAGCAAATAACAGTGCAGGACGGTGCGGACATGAACGCGCACAACGATAACGCGAACGGTGCCACCAGTAGTGACACAAAGCAAGAAAAATTCGAAGACAGTATTTCTGAACAAAACAGCAATGACACGGACCAAAACATTGGTGTTACTAATAACAGTGTGGACCATACTGTTGATAACTCTGGTGACGACTTAGATCAAATATTTGATGACCTCGATAGTGACGAAGAAAAGGACGATAATACCAGTGCCGGGGAACAGAACAATGATGGCACTGGCCACGGAGACATCGAGGACAGAATGAGTAACAGTGATACGGATCATGTAATCGAAACAAACCATAGTGACGGAGTTAACGGAAAAGATAATCAAAGTGCTACGTCCGCTACTgaggaaaaaattaaagatgaaccACGTAGCGGCAATGACAGTATTGATACGTATACTCAAAGTGACGTTGAAGTTCACAGTGAAGGTACTGCCGGAGTCACTGTTCAACTTAATaaattgaaaaatgcaaatacTCCTATCCAGGATCATTTAGAGCAGGATAAGGTGAACTTTGTTGCTAACAAAAGCTCCAGGAATGCCTCAGAAGAGCGAATCAGGAAAAAGAATAATAGCGCCACCTGGAACTCGGGCGAAGAACTCGAAGACGACGATGCTTTCATCTTCGATTACCTGGACAAGAGTAACGATAAGGCAGAAGCTCGACTGGCTGCGCGTCGACAAGCCAGAGCAGAGGCAAGAGAGATCCGTATGCGAGAGCTCGAACGTCAACAGAAGGAGAATGAGGAAAACCACGACTCTGTGTATGATATGTATAGTAGAGGTACGCTGCTCTTTGTGTAA
Protein Sequence: MSTLCRADKNMGNSAGNEEVRHEEEQITVQDGADMNAHNDNANGATSSDTKQEKFEDSISEQNSNDTDQNIGVTNNSVDHTVDNSGDDLDQIFDDLDSDEEKDDNTSAGEQNNDGTGHGDIEDRMSNSDTDHVIETNHSDGVNGKDNQSATSATEEKIKDEPRSGNDSIDTYTQSDVEVHSEGTAGVTVQLNKLKNANTPIQDHLEQDKVNFVANKSSRNASEERIRKKNNSATWNSGEELEDDDAFIFDYLDKSNDKAEARLAARRQARAEAREIRMRELERQQKENEENHDSVYDMYSRGTLLFV

Sequence clustering based on sequence similarity using MMseqs2