Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.6e-28 1.6e-23 86.2 3.2 223 300 37 119 24 119 0.87

2 3 0.0035 2.2e+02 3.7 3.8 120 172 117 169 116 174 0.91

3 3 0.13 8.2e+03 -1.5 6.6 135 166 153 184 138 194 0.43

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.6e-28	1.6e-23	86.2	3.2	223	300	37	119	24	119	0.87
2	3	0.0035	2.2e+02	3.7	3.8	120	172	117	169	116	174	0.91
3	3	0.13	8.2e+03	-1.5	6.6	135	166	153	184	138	194	0.43

Coding Sequence: ATGACCGAAAGGAAGCAAGACTATGAGCTGAGGCATGTAGTAAGCAACGATTTCACTTCAAACTATGCTGCACCAAGAGCTTTTATGAATCTTATGAATACTGCTTATGTAAGACTGCGAAGGTTTGCGGAAGAACGGAATGAATTATTAGATCAGGTGCGGCATCTTAAGCTAGAATTGGAAGAAGAGCGAAGTAGGCACAAGTCACAGCACCACCGCCTTTCTTCTGGTACTTCTGCCTCTACAGCTAGCCTTAATGGCCCTGATACTGATATTGTGGATTTACAACGAGAAGCCAACAAACAATTAGGTGATTACAAGTTCAAGCTTCAAAAAGCAGAACAAGATGTGTCAACGTTGCAGGCCAATGTTGCACGCTTGGAAAGTCAGGTGATAAGGTATAAATCTGCCTCAGAGACTGCTGAGAAAATAGAAGATGAACTGAAGGTGGAGAAAAGAAAATTGCAGAGAGAGCTTCGTGAAGCGCAAGCAAGAGTAGAAGAGTTAGAAACATCTAATACACATCTGCAGCGTAGACTAGACAAGTTGAAGAATGCCAAGTCTGCACTGCTTAAAGAACTTTGA
Protein Sequence: MTERKQDYELRHVVSNDFTSNYAAPRAFMNLMNTAYVRLRRFAEERNELLDQVRHLKLELEEERSRHKSQHHRLSSGTSASTASLNGPDTDIVDLQREANKQLGDYKFKLQKAEQDVSTLQANVARLESQVIRYKSASETAEKIEDELKVEKRKLQRELREAQARVEELETSNTHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2