Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.00074 5.9 7.5 0.0 21 46 17 42 5 45 0.88

2 10 0.0011 8.4 7.0 0.0 21 46 45 70 41 72 0.89

3 10 0.001 8 7.1 0.0 21 46 73 98 69 101 0.89

4 10 0.0035 28 5.3 0.1 21 46 101 126 97 132 0.88

5 10 0.0076 60 4.3 0.0 21 46 129 154 125 160 0.87

6 10 0.014 1.1e+02 3.4 0.0 11 45 146 181 145 185 0.76

7 10 0.006 47 4.6 0.0 21 46 185 210 177 216 0.85

8 10 0.01 80 3.9 0.0 11 46 202 238 199 244 0.78

9 10 0.006 47 4.6 0.0 21 46 241 266 233 272 0.85

10 10 0.025 2e+02 2.6 0.0 11 44 258 292 256 293 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.00074	5.9	7.5	0.0	21	46	17	42	5	45	0.88
2	10	0.0011	8.4	7.0	0.0	21	46	45	70	41	72	0.89
3	10	0.001	8	7.1	0.0	21	46	73	98	69	101	0.89
4	10	0.0035	28	5.3	0.1	21	46	101	126	97	132	0.88
5	10	0.0076	60	4.3	0.0	21	46	129	154	125	160	0.87
6	10	0.014	1.1e+02	3.4	0.0	11	45	146	181	145	185	0.76
7	10	0.006	47	4.6	0.0	21	46	185	210	177	216	0.85
8	10	0.01	80	3.9	0.0	11	46	202	238	199	244	0.78
9	10	0.006	47	4.6	0.0	21	46	241	266	233	272	0.85
10	10	0.025	2e+02	2.6	0.0	11	44	258	292	256	293	0.73

Coding Sequence: AAATTTTCTGAAAGTGGTAATTTGAAAACACGTTTAGGAATACATTCTGGTGAGAAACCATATAAATGTGATATATGTGACAAGAAATTTACTATAAGTGGTAATTTGAAAACACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGATATATGTGACAAGAAATTTACTATAAGCGGTAATTTGAAAACACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGCGATATATGTGACAAGAAATTTACTATAAGCGGTAATTTGAAAACACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGACATATGTGATAAAAAATTTACTGAAAGTTGTAGTTTGAAAACACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGATATATGTGACAAGAAATTTACAGAAAGTGGTACTTTGAAAATACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGACATATGTGATAAAAAATTTACTAGAGGTGATTATTTGAAAACACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGATATATGTGACAAGAAATTTACAGAAAGTGGTACTTTGAAAATACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGACATATGTGATAAAAAATTTACTAGAGGTGATTATTTGAAAACACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGACATATGTGACAAGAAATTTACAGAAAGTGGTACTTTGAAAATACATTTACGCGTACATTCTGGTGAGAGACCATATAAATGTGACATATGTGATAAAAAATTTACTAGAGGTGATTATTTGAAAACACATTTACGC
Protein Sequence: KFSESGNLKTRLGIHSGEKPYKCDICDKKFTISGNLKTHLRVHSGERPYKCDICDKKFTISGNLKTHLRVHSGERPYKCDICDKKFTISGNLKTHLRVHSGERPYKCDICDKKFTESCSLKTHLRVHSGERPYKCDICDKKFTESGTLKIHLRVHSGERPYKCDICDKKFTRGDYLKTHLRVHSGERPYKCDICDKKFTESGTLKIHLRVHSGERPYKCDICDKKFTRGDYLKTHLRVHSGERPYKCDICDKKFTESGTLKIHLRVHSGERPYKCDICDKKFTRGDYLKTHLR

Sequence clustering based on sequence similarity using MMseqs2