Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00011 0.94 10.2 0.1 16 50 41 75 32 79 0.85

2 6 0.00019 1.7 9.4 0.1 23 45 76 98 70 101 0.89

3 6 0.0017 15 6.4 0.2 20 44 101 125 97 134 0.85

4 6 0.03 2.6e+02 2.4 0.1 21 44 130 153 127 160 0.90

5 6 0.0012 10 6.8 0.0 23 45 160 182 155 188 0.91

6 6 0.51 4.4e+03 -1.6 0.0 22 34 213 227 209 236 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00011	0.94	10.2	0.1	16	50	41	75	32	79	0.85
2	6	0.00019	1.7	9.4	0.1	23	45	76	98	70	101	0.89
3	6	0.0017	15	6.4	0.2	20	44	101	125	97	134	0.85
4	6	0.03	2.6e+02	2.4	0.1	21	44	130	153	127	160	0.90
5	6	0.0012	10	6.8	0.0	23	45	160	182	155	188	0.91
6	6	0.51	4.4e+03	-1.6	0.0	22	34	213	227	209	236	0.73

Coding Sequence: ATGGCCTCTACTGAGGAATATGAAGAAACTATCCCCATGAATGGTGTAGTTTCCATGTACACATGTAAAAGATGCAACAAGATATTTCCCTGCAAACGTGACCAGCTTTTGCATAAGAAGGAAGTACATTCACAAACAAAGTCTTCGTACGAATGCAAAATATGCCAGAAATACTTCTGTAATAGCGGAAACCTGGAGCGACATATGAAGGTCCACAATGATGTACGGCCATTTGTGTGCCGAATATGTGGGAAGGCTTTCGCCCAGTCTGTTAATTTAAACCGCCACTACTCGGTCCACAACGGAGAGCGGCCATATCAGTGTACATTCTGTACGAAATCGTTTACCCAGCAATCTAACATGCAACGCCACCAACTAACCCACACCGGCGAGAAGCCGTTCCGCTGCAAACGTTGTGGACGCTACTTCTCACAACGGGTTAACCTTAAGAAACACATTATGGGCCATTTGAATACGAAACCCTACACGTGTCGGATCTGCGAAAAGTCGTTCATTCAATTGGGTAACTTTAAAAAACATCTACAGTCGCACGTTAAGGATGGCATTGACATTGATATGAAGGCGACCATTGAGGAGGCGCAGGCAATAGCAAAACAAAATCTTGAAATGGCCGATGAGCAACCGGTGGGTTTTGAATGTGCTGTCTGTCGTTCAGTCTTCAACAATTTTACCGATTTTGAAATGCACGAAAGCGAATGTAATGATCATGCTCAGGCTGCTATCGAACAGAAATATAATCCCGATCAACAAATGCACGAGGTGATTATTGAGGAGGCCGAGGAACATGTGCCCATTGAGACTGGTGCCAATTTGGGGGCATTTGCTCCATTAAAGTTTAGTGTTTCCCAGTTGGATACACATGAAATTATCATTGAGACCAGTCGATAA
Protein Sequence: MASTEEYEETIPMNGVVSMYTCKRCNKIFPCKRDQLLHKKEVHSQTKSSYECKICQKYFCNSGNLERHMKVHNDVRPFVCRICGKAFAQSVNLNRHYSVHNGERPYQCTFCTKSFTQQSNMQRHQLTHTGEKPFRCKRCGRYFSQRVNLKKHIMGHLNTKPYTCRICEKSFIQLGNFKKHLQSHVKDGIDIDMKATIEEAQAIAKQNLEMADEQPVGFECAVCRSVFNNFTDFEMHESECNDHAQAAIEQKYNPDQQMHEVIIEEAEEHVPIETGANLGAFAPLKFSVSQLDTHEIIIETSR

Sequence clustering based on sequence similarity using MMseqs2