Hcyr000801.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Hydrotaea cyrtoneurina
Gene Symbol
MBD-R2
Assembly
GCA_958296145.1
Location
OY282512.1:14930257-14934139[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3e-20 1.3e-16 60.5 0.1 4 76 410 480 407 481 0.93
2 2 3 1.3e+04 -3.6 0.0 46 58 915 927 913 934 0.77

Sequence Information

Coding Sequence
ATGGGTCGCCGGTGTTGTATTACAGGCTGTACGTCAACATCACGTTTGCCGGAACATCATGGTGTAACATATCATTCATTCCCGGTGGATGAGAACACCCGTACCATATGGATTAAGAACACACGCATAAGTACAGATCGCCCCATCACCAAAAGTGTTTTGGTCTGCTCCCGGCATTTTCGCAGGGCCGACTTTCAGCCGCAGCGTAGTGGGAAATATTTGCTAAAACAAAAGGTTTTCCCAACCGTTTTTCCGTGGGGTAAGATAGAGGCTGCTCAAATCGAAGTGGATATGGAATTTCTCAATTCGTCGGTTGCGGCAGCGCCCAGTAATCTGTTGGCAAACTCATCGACGACCTCGGTGGACGAAGACACCAAGGTGGCTGCTACAGTGGCTCAAATAATGGCGCAAACGGCCGAACTTAATGCAGCAGCTGCAGCTGCCTTAAAGGCGGAAAAGTCCAACGACAGTCAGGACGATTCTCTGCAAGATGTTGGTCCCAACTCATCGACGCCTGGTGTAAAATTCGAACCAGTCACTTCTTTTAACCCCGGAGCTCGCCTGGAGGCTCAAGATTTCGATGGAAACTGGCATTCGGCTCGTATTGTCGAAGTGGACAATGACGACCGCGAGGTATTGATTAAATTTGAAAAGACCGGCAAAAACAAGTCGCCCATTGTCGGCACCGAAGAATGGATACCGATGAATTCCTCCCGATTACGTCAAAGAATCTCTACAAAGCCCATACTGGTTTTCAATTTGGAAGAGAAATGTTTGGCCCGTTGGTCCGGACCACGTAAATTTCCCGGCGTCGTTAAGAAGATTCTTGGCAACGACAGTTACGAGATTCTATTCGATGAtggatttgtgaaaaatgtccGAGCCATTCATATGAACAAAGTGCAGTCGACTGAAGCTCAGCCACAGACAGAGGACATTCCTGAGACCGCTGCGCCAAGTTCACCTTCTACACCAGTGGCGACATCCACCTTGTCGCCGGGAGCTAAGAGACCATCTTCGGGTTCAAGTGGAGGTACGAAACCAAAGAAACGGTCCTCGCATTCCTCGAGGAAAGATTGGCCATTGTTGGATTTGTCAAAACTGGATTTGGCCTCTCTGAATCTTCCCGATATTCCAAGAGACGGTGAGTGGGCCTGTCATTGGGTCAATGATCAACCTATCGGCCGTGAGGGGTTCCTCGTAGTGGGCGAACATCGCAAACCTACCGTCATTGTAGAGGATTGGCGTTTACCGCCCGGCTGGGTTAAACATATGTATCAACGTTCTAATGTTCTCGGCAAATGGGATGTGATTTTAGTCACACCCAGTGCAAAACGTTTCCGTTCAAAGGCGGACCTCAAGACATTCTTGGAAGAACAGGGCCAGGTATACAATCCAGACATTTATGACTTTAGCATACATCGTCGAAGAGCCAAAGATATCAACTGCTACGTTTACACACCGGGCTATGTGCCACAACAGCCGTTAAAACAGAAGCCAACCCTAAACTATGATACATTAGATAATAATTCCTCACCATTGGGGGACACACTAAACACTTCGGTACCGTCGCCTTATATGGAGACACCAGTAGCGGAACCTCTGCCACCAATAGAATTGTTAACGTCGACTAGTTTGTCGGCCGAAGACAAAAGCGTAACACAAGTGGAAGCAGAGGTGCCCAAACAACTTTTGGAATCTGCAGAGATTAGTTCAACGCCTACTCCTACATCAACACCTACAGTAGGTTTGAAAGAGGAAATCGTGGTTACTAGTGAGGCTAATGCGTCAAGTACTCCAGAGCCCTCGAGTGTAACGGATGCTGCTTCCATAGTGGAAGATGGTTATGCTCTTATTGGCGGTCTAAAGGTTCAAATCATTGATAATCTCTTCCGTTGTCCTGAAGAGGGGTGCTCTAAAAACTTCCGCAAAGAGAATCATTTGCAAATTCATGTCAAGCACTATCATCTCCATTTAATCAAattaCTTGGCTCTTGTCCAAAAATGCAAGAATTGGCAGAAAAGCGCACACGCCCAGTCAGTCATGAGATCAATGAACCGGCTCCAAAGAACCAAATACCCAATCAACAGTTCTTTGCTAAACTGCATCAACAAGACTTGGAGCAAACCAGATCCCATCGTAGGAGTCTGGGAGCCGTGAAACCACATACCGAACTAAATGCAGATATAAAACCGGATGTTGTAGAAGGACAAATTAAACCTGAGGTTGGGGATCAGTCAATTCCAATCGGCAATCCCGAAACATCAGTTACAATGAACACTACTACCTCAACACCGACTACATCCATTCTGGAAAGTTCTTATGCATCCACTGGTGCTGATGATTCCACCATCAAAGACGACGATTTGCCCGAAATCCCCCCTTTGTCCAAGAAATCACGATTTTCACCTTCCAAGAGAACGCCGGGAGCGAGAAAAAGTAATCGTCAACGCAccacaaagaaatatttaacaGCTGCCCAGGCTAGTGCCAGTAGGAAAACGCTAACTACATCCCTGCCTTCATTGCATATACCACCGGTAGACTCCAGTTTCAGTGGAGTCGCAGACTTTGAAGAAACCCGGCACTCGTTCAATGCCACACCAGAAAGTAACAAAGACAATAAAAAACGCAGAGCTAACATACCAACCAATACGCCCATGAGTAGTGTAGAATCCCCCATGACTGCCGACTCGGGATCTAGTTCTATGCAACCCACGTCCACAACAGAGACCGATACCATAGCTCAGACAACTCAGTACATCAAGGAAAATGGTGAACTAATAAAGATTGTTCGCATGCGTCAAGAGGAAATCATCAATTGCCTGTGTGGTTACGTTGAGGAGGACGGTCTGATGATTCAATGCGAACTGTGCCTGTGTTGGCAACACGGTTTGTGCAATGGCATTGACAAAGAATCCCAAGTGCCCGATAAGTATGTATGCTATATCTGCCGCAACCCAGTGAGAAGTCGGCAATCATTACGTTTTAAGCACGACCAAGATTGGTTGTACGAAGGCAAGTTGCCCACGGCCAATTATCATACACAAAACACGTCTTTGACCAATAAAAGATCGGAATACTTGAAACGTTCTCACATTTTGACTGGAAATCTGCTAGAGTTGAAGAATTTCATGCATTCGTTAAAGGTTAAAATCAATATAGCCAACAATAAATGCCACCCGAAATTGTATTTATGGGCGAAAAAGTGGGATGAGGATAAAATCAAGACAGAACCCATTACTCCGGTTATACCAGTGCCCAATATACCACAACCCGAGGCGCCGATTGATCCCGTAGAGTGCCAACAACGGTTACAAGAACATATCAAAATACAGCAACATTTCGTAATGCAGCGTTTGGAAGATATAGAATCGGCCATAGACGTTTTGGAGCAAGAAGACGATTTGCCTGATCTGCATGACGCCGATATGAGTGCCAACAAGGACATTTTGGCCGCCTTCATCAAAGAGTTGGATACtgtaaaacaaattgcaaaattgAATGCTTTGGAGCATACAAAGATGGCCCTGAAGAATCCTCCACCCGCAGTTTAG
Protein Sequence
MGRRCCITGCTSTSRLPEHHGVTYHSFPVDENTRTIWIKNTRISTDRPITKSVLVCSRHFRRADFQPQRSGKYLLKQKVFPTVFPWGKIEAAQIEVDMEFLNSSVAAAPSNLLANSSTTSVDEDTKVAATVAQIMAQTAELNAAAAAALKAEKSNDSQDDSLQDVGPNSSTPGVKFEPVTSFNPGARLEAQDFDGNWHSARIVEVDNDDREVLIKFEKTGKNKSPIVGTEEWIPMNSSRLRQRISTKPILVFNLEEKCLARWSGPRKFPGVVKKILGNDSYEILFDDGFVKNVRAIHMNKVQSTEAQPQTEDIPETAAPSSPSTPVATSTLSPGAKRPSSGSSGGTKPKKRSSHSSRKDWPLLDLSKLDLASLNLPDIPRDGEWACHWVNDQPIGREGFLVVGEHRKPTVIVEDWRLPPGWVKHMYQRSNVLGKWDVILVTPSAKRFRSKADLKTFLEEQGQVYNPDIYDFSIHRRRAKDINCYVYTPGYVPQQPLKQKPTLNYDTLDNNSSPLGDTLNTSVPSPYMETPVAEPLPPIELLTSTSLSAEDKSVTQVEAEVPKQLLESAEISSTPTPTSTPTVGLKEEIVVTSEANASSTPEPSSVTDAASIVEDGYALIGGLKVQIIDNLFRCPEEGCSKNFRKENHLQIHVKHYHLHLIKLLGSCPKMQELAEKRTRPVSHEINEPAPKNQIPNQQFFAKLHQQDLEQTRSHRRSLGAVKPHTELNADIKPDVVEGQIKPEVGDQSIPIGNPETSVTMNTTTSTPTTSILESSYASTGADDSTIKDDDLPEIPPLSKKSRFSPSKRTPGARKSNRQRTTKKYLTAAQASASRKTLTTSLPSLHIPPVDSSFSGVADFEETRHSFNATPESNKDNKKRRANIPTNTPMSSVESPMTADSGSSSMQPTSTTETDTIAQTTQYIKENGELIKIVRMRQEEIINCLCGYVEEDGLMIQCELCLCWQHGLCNGIDKESQVPDKYVCYICRNPVRSRQSLRFKHDQDWLYEGKLPTANYHTQNTSLTNKRSEYLKRSHILTGNLLELKNFMHSLKVKINIANNKCHPKLYLWAKKWDEDKIKTEPITPVIPVPNIPQPEAPIDPVECQQRLQEHIKIQQHFVMQRLEDIESAIDVLEQEDDLPDLHDADMSANKDILAAFIKELDTVKQIAKLNALEHTKMALKNPPPAV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01231582;
90% Identity
iTF_00816594;
80% Identity
iTF_00816594;