Basic Information

Gene Symbol
klhl26_1
Assembly
GCA_013841215.1
Location
JACDRQ010000130.1:85970-89097[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 6.6e-35 1.3e-32 111.8 0.8 1 109 32 138 32 139 0.98
2 4 9.8 1.9e+03 -1.5 0.0 80 109 141 170 137 171 0.84
3 4 6.8 1.3e+03 -1.0 0.0 58 77 182 201 163 223 0.71
4 4 0.91 1.8e+02 1.9 0.0 53 78 234 259 222 275 0.80

Sequence Information

Coding Sequence
ATGACTCGAATTCAGGAGAAACTCCTCCACGATAAACCGTGGAATTCAACATTCTACCAACATCCATTCCACCAATCCACCCTGTTGGAAGGTTTGAATTCGTTGCGTGAAAAAGGCGAACTATTGGACATAACATTGATCATTGAGGAGCAAATTTTCAAAGCACACAAAGCTGTATTGTCAGCATGCAGTGATTATTTCCGTGCCATGTTCACCGATAATATGCTAGAATCACGACAACGTGAGATTCGTTTGAATGGAATCACAGCCAATGGTTTTGATCATCTATTAGAATACGCATACACATCATCGTTAGTATTGAATTTGAATAATGTCCAAGATGTATTAGAGGCGGCATCGCATGTACAAATGAATGCTGTAATTGAAGCTTGCGAACAATATTTACAAAACCAAATCGATATCGATAATTGCGTCGATATCGCTACAATCGCTGAAATTTACACATTACCGATATTGAAGACGAAAGTTTATCGTTTTATGAGCGAAAATCTATTGGAGTTTTCAAATTCGAAAGAATTCTACCGACTAACACCGCAACAATTGGAGAAATTGCTAGCCTACGATTATCCGGTTGATTGTTCCGAGGCTGATGTCTTACGCATCATTCTAGCTTGGTTCTTCCACGTGGACACTACCAAGCTAGAAGTGCGCTTTTCGTACGCTATTCGGATTATCCGGCACATTCATTTCAAAGAGATTTCGCCGCGTAAATTGCACAATATTTTAGATAAAATCTTTCAAGAGCGCAAAAACGACTGGGAATTGTATAAAATTGTATTATCCGAAGCGCGTCTGCAGAGTAATTGTTATAAAATGTTGCCAAATGTGAATTTGTTGAATTCAAGGGGAATGGAGCGTGCAATTCTAAAAATCGGCGGTTTCGGTTTGAATGGCATCACAAATGAGATCACTTATTGTTTCTATCGCGAGAAGAAATGGCGCCATCTAACGGCAATACCGCACGTTGAACAATGCAATTTCGGTACGGCGGTTTTAAACAATGAATTATACATTGTCGGCGGTTGTTTCAATCAATCATTACAAGAGATAATCCACCCGTTCGGTTTCAAATACAGTCCACGTTACGATAAATGGTCGACAATATCGCCGATGAAAATCGAACGTTGTCGCTTCTCACTGAATGTTATTGGTGGTATGCTATACGCCGTCGGTGGTTGTAGTGAAATCGATGAATTCGATACAAGCACATGTGAATGTTACGATCCAGTCTTGGACATGTGGTATATGATTAAATCATTGCCAGCTTATTTAACCCAACATGCCGCCGCTAGTTGCGAATACAACTTAGATTTGAAATTATTCATCAGTGGCGGTATGGATCGTGATACGATCCAATCAGCGATGTACTGTTACACAATCAACGAAGATAAATGGCACCATTGTGCACCAATGTTGAAAGCCCGTGCCGATCACACGATGTTAACCATCGGTGATTTCTTGTACGTGTGCGGCGGTTGGACTGAAGGTACCGACAATCGATCGCGCCTATTAGTTGATACAATCGATAAATATGATGTTAAGAATGATCAATGGAGCATTATCACGAAAATACCAACGCCCCGGTATCACGCCGGTATTGTTTGTGTTGATCGGAAAATCTATTTTATTGGCGGTTTCTACAGCGATGATATGTTCGATAAGAGTACAGCGGCTATTGAATATTATAATATTGATACGGATCAATGGACAATTGAGGAGAAATATCCACAGGATATATGGGAGCATACGTGTGCTACATTGTTTGTACCGAAATGGCGTGACGATAAGCAGGATATGGAGGTTGTATCATCAACGAATAGTACCACTTGA
Protein Sequence
MTRIQEKLLHDKPWNSTFYQHPFHQSTLLEGLNSLREKGELLDITLIIEEQIFKAHKAVLSACSDYFRAMFTDNMLESRQREIRLNGITANGFDHLLEYAYTSSLVLNLNNVQDVLEAASHVQMNAVIEACEQYLQNQIDIDNCVDIATIAEIYTLPILKTKVYRFMSENLLEFSNSKEFYRLTPQQLEKLLAYDYPVDCSEADVLRIILAWFFHVDTTKLEVRFSYAIRIIRHIHFKEISPRKLHNILDKIFQERKNDWELYKIVLSEARLQSNCYKMLPNVNLLNSRGMERAILKIGGFGLNGITNEITYCFYREKKWRHLTAIPHVEQCNFGTAVLNNELYIVGGCFNQSLQEIIHPFGFKYSPRYDKWSTISPMKIERCRFSLNVIGGMLYAVGGCSEIDEFDTSTCECYDPVLDMWYMIKSLPAYLTQHAAASCEYNLDLKLFISGGMDRDTIQSAMYCYTINEDKWHHCAPMLKARADHTMLTIGDFLYVCGGWTEGTDNRSRLLVDTIDKYDVKNDQWSIITKIPTPRYHAGIVCVDRKIYFIGGFYSDDMFDKSTAAIEYYNIDTDQWTIEEKYPQDIWEHTCATLFVPKWRDDKQDMEVVSSTNSTT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00814487;
80% Identity
-