Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5e-21 2.3e-17 63.0 0.0 1 73 7 75 7 79 0.90

2 2 4e-05 0.18 12.0 0.0 27 73 105 160 82 164 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5e-21	2.3e-17	63.0	0.0	1	73	7	75	7	79	0.90
2	2	4e-05	0.18	12.0	0.0	27	73	105	160	82	164	0.83

Coding Sequence: ATGAATCCTAATATTACCATAGAACGCAGACGAACAGATTGTAATTCGTTACCAAAAGgttggcAACGAGAAGAAGTTAAAAAATCTGGTTCTAATTTATCGTCTGGTAAAGTTGATGTCTACTATTATAGtCCAAcgggattaaaaataaaatcaaaaccaCAATTGGCACGTCAATTGGGCGATGTATTTGACGTTTCATCATTTGATTTTCATACTggtaaaataatatcaaaccGTTCAAAACGTAGTAATAATATTAGTAGTGGCTCATCTTGTTCTACTGTTTTATCTAAGCACCTTGATTTCAGtcgTAACATAAGAACTGATATATCATTGATACCGCCAATTCGGCAAACTGCTTCGATTTTTAAGCAACcgataacattaataaaaaatcacgaAGGTGGCAAGGTGAAGCATGATTCTAAAAATGGTAACCAAGATAAACCAAAACAATTATTTTGGGAAAAACGTTTAGAGGGTTTAATAGCTTGTAACATGGCAGGTGAGGAATATGATAAAATCGAATTGCCTAAAGGGATTAAGGCAATCGGCCCGAATGTTTATGATCAGACCGTACTGCAATCcgTTGCTACAGCTTTACATATTTCAACTCAACCAGTTACTGGACAGTCTACTGATAAACAGATATTGCAAGCTAATTCTGGTGCATTTTTAAATCCAGATCAACCTCTAATGCAGTCTGTAAATATAAATGAAGAGGATATAAGGCGACAAGAAGACCGCGTCAGTGttgcaagaaaaaaattgcAAGATGCTCTCAAAGGCTAA
Protein Sequence: MNPNITIERRRTDCNSLPKGWQREEVKKSGSNLSSGKVDVYYYSPTGLKIKSKPQLARQLGDVFDVSSFDFHTGKIISNRSKRSNNISSGSSCSTVLSKHLDFSRNIRTDISLIPPIRQTASIFKQPITLIKNHEGGKVKHDSKNGNQDKPKQLFWEKRLEGLIACNMAGEEYDKIELPKGIKAIGPNVYDQTVLQSVATALHISTQPVTGQSTDKQILQANSGAFLNPDQPLMQSVNINEEDIRRQEDRVSVARKKLQDALKG

Sequence clustering based on sequence similarity using MMseqs2