Basic Information

Insect: Hoplodrina ambigua
Gene Symbol: topi
Assembly: GCA_949774945.1
Location: OX458979.1:12452176-12457127[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.00053 0.039 15.0 1.0 1 23 266 288 266 288 0.98

2 12 0.028 2.1 9.6 1.8 2 23 296 317 295 317 0.93

3 12 0.009 0.67 11.1 0.2 1 23 321 343 321 343 0.95

4 12 1.9e-05 0.0014 19.6 1.0 1 23 348 371 348 371 0.98

5 12 0.00068 0.051 14.7 0.3 1 23 375 398 375 398 0.94

6 12 0.0056 0.41 11.8 0.2 2 20 413 431 413 437 0.93

7 12 0.00095 0.07 14.2 0.6 3 23 446 466 446 466 0.98

8 12 0.0023 0.17 13.0 0.5 2 23 488 510 488 510 0.97

9 12 3.4e-05 0.0025 18.7 0.4 1 23 521 543 521 543 0.98

10 12 5.7e-07 4.2e-05 24.3 1.8 1 23 549 571 549 571 0.99

11 12 0.0003 0.022 15.8 2.2 1 23 577 599 577 599 0.98

12 12 7.1e-07 5.3e-05 24.0 0.7 1 23 605 628 605 628 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.00053	0.039	15.0	1.0	1	23	266	288	266	288	0.98
2	12	0.028	2.1	9.6	1.8	2	23	296	317	295	317	0.93
3	12	0.009	0.67	11.1	0.2	1	23	321	343	321	343	0.95
4	12	1.9e-05	0.0014	19.6	1.0	1	23	348	371	348	371	0.98
5	12	0.00068	0.051	14.7	0.3	1	23	375	398	375	398	0.94
6	12	0.0056	0.41	11.8	0.2	2	20	413	431	413	437	0.93
7	12	0.00095	0.07	14.2	0.6	3	23	446	466	446	466	0.98
8	12	0.0023	0.17	13.0	0.5	2	23	488	510	488	510	0.97
9	12	3.4e-05	0.0025	18.7	0.4	1	23	521	543	521	543	0.98
10	12	5.7e-07	4.2e-05	24.3	1.8	1	23	549	571	549	571	0.99
11	12	0.0003	0.022	15.8	2.2	1	23	577	599	577	599	0.98
12	12	7.1e-07	5.3e-05	24.0	0.7	1	23	605	628	605	628	0.98

Sequence Information

Coding Sequence: ATGGAACTCATGAAAGTGTgtcgtttttgtttattaatggACGTGAAATTACACGATCTGCGATCGTACCCATTGGAATGTTATTATGAGTCTGTTATTGGAACCAATCCCAAGTATGCCACCCTGCCTCCATATGCCTGTTATGAATGTGCAGCACTTGTGAGgaagttttatttctttagacAGAAATGTCTGCGAAGCCAGGCTGTACTCTTTGGCACTATAGAAGACTATGGAAAGTTAGAATCAAGTGAAATAAGATTAATAAACAGAAAAGATCTCCACATCATTTCAAACCTCAACATCACTACCCTGCCAGACTTAGAAATATGTCCGCAACATAAAactcaaacaaagaaaaaagtaaaacatgaaCCAAATAAAGAGAATAGGTATTATACTGGAGATCATAACTATGCTGCCTTGTTAAAAGACCCTAGTCTCTCCAGCAGTGATAATGAACTCACATTGGTTGATAAGGAGATGAAAAGTCAAAATAAGAATTCTCAGAAGGAGAATGCGGACTTGAAAGAGACAAGTGTTACGTTTGCTGTTGGCACAGAAGACTTGGAACATACAATAGAAGGACCTGACACAATAGAGAGGAGGGAGAAGCAAAAGACGTGCCAGCTAAGGAAAAAAGTAAAGCATAAAAAACAGTTGATAAACCCAAATCTGGCTGCTGATGACAAAAGTGATTTTGCACAGTACATCACTGTTATAACTTTGTCGCTGAAAGAACAGAAAGAAGAGATACAGAAGCGGAAAGAGTCATCTAACTACTTGTATGCAACATACCAGTGTAATCTATGCTATAAAGGGTTCATTGATAGTGAAGCCTGGAATCATCATGTCAGTAAACACTCTGCGaGCGCAGGCAGCATAGAATGTGAAGTCTGTAAATTGAGGTTTAAATCGAAGTACGTCTATTGTAAACATGCGGCCAACCACGAGAAAAAATACGTCTGTAAATTATGTCCATATGTATCGACTAGCAAGGCTCAAGCAAAGCAGCATCAAGGGTGGCATAAAGGAATTACTTACAAGTGTAAATATTGTGATGAAATCTTCACTATGTGGACGTCGTACATGGGCCATATGCGCATCAAACACCCGTCAGAGTTCATATGCAGTTACTGCGGGTACTCCTTTATCAGCAAGTTGGGCCTCGCCATGCACAAGACGATGATGCACAAGGGTATTCAAgAGAAAGCAGAACACGACACAGAAAGTCCATATTGCGAAGAGTGTGACGTTAAGTTCATATCAATGGAGTCGTACAAGAGACACATGGTGATGTCTGTAAAGCACACACAGAGTACAGAAATTAAAGGCTGTCGGACCTGTGGTGCGACTTTCGAGAATCCTGATGAATTTCGGCAGCATCGTAAGGAACACGCGCGATTGAGACCCAAGAACTACGGGAAGAAACCTAACACTAACATCAGTAGTTGGCCTGCGAAATGCGAACACTGTCCAGAAGAATTCCCCAATGCCCTGGAGTATTGGAAGCACTTCCGTCGAGCGCATCCCGACGAGAACTACCCTGTGCAGAGGAACTATATGTGCGATATATGCGGCAAGAGTTTTGGGGCAAACGCATTCCTAATGTACCACAGACGCACGCACTTCGAAGACCGGCCGTATAAATGTTCGCAGTGCGACAAATCTTTCTTCAACCGACCCAACTTGGTCTTACATATGAAAACGCACACGGAAAACAGGCCGTACCCATGCACCGTCTGTTTCAAAGCTTTCAAGTGTAAGGGAGCACTTAAAAGACATATTCAAAGTCACACGGGTCAAAAACCCTACGAATGTGAAGTGTGCGGCAAAACGTTCACTCAGTCAAGTAGCAGGAAACTTCACGTACGCACGGTACATCTGAAGCAACCCGCGCTCCGTCGCAACCGCCTCGAGAGACGACTAAAGGAACCGCTTGAACAGTTTATATACTAA
Protein Sequence: MELMKVCRFCLLMDVKLHDLRSYPLECYYESVIGTNPKYATLPPYACYECAALVRKFYFFRQKCLRSQAVLFGTIEDYGKLESSEIRLINRKDLHIISNLNITTLPDLEICPQHKTQTKKKVKHEPNKENRYYTGDHNYAALLKDPSLSSSDNELTLVDKEMKSQNKNSQKENADLKETSVTFAVGTEDLEHTIEGPDTIERREKQKTCQLRKKVKHKKQLINPNLAADDKSDFAQYITVITLSLKEQKEEIQKRKESSNYLYATYQCNLCYKGFIDSEAWNHHVSKHSASAGSIECEVCKLRFKSKYVYCKHAANHEKKYVCKLCPYVSTSKAQAKQHQGWHKGITYKCKYCDEIFTMWTSYMGHMRIKHPSEFICSYCGYSFISKLGLAMHKTMMHKGIQEKAEHDTESPYCEECDVKFISMESYKRHMVMSVKHTQSTEIKGCRTCGATFENPDEFRQHRKEHARLRPKNYGKKPNTNISSWPAKCEHCPEEFPNALEYWKHFRRAHPDENYPVQRNYMCDICGKSFGANAFLMYHRRTHFEDRPYKCSQCDKSFFNRPNLVLHMKTHTENRPYPCTVCFKAFKCKGALKRHIQSHTGQKPYECEVCGKTFTQSSSRKLHVRTVHLKQPALRRNRLERRLKEPLEQFIY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00274644;
90% Identity: iTF_00810330;
80% Identity: -