Basic Information

Insect: Hirtodrosophila trivittata
Gene Symbol: MBD-R2
Assembly: GCA_035045065.1
Location: JAWNNK010000855.1:10216169-10220300[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.4e-21 4.3e-18 65.0 0.1 4 76 464 534 461 535 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.4e-21	4.3e-18	65.0	0.1	4	76	464	534	461	535	0.93

Sequence Information

Coding Sequence: ATGGGTCGCCGCTGCTGCGTTGCCGAATGTCCGTCGACATCGCGGCTCTTGGAACATCATGGCGTTACCTATCACTCGTTTCCGATGGACGCAGTCATACGGGCCATTTGGATAAAAAACTCGCGCATTAGTCTGGATAGACAAATTACAAAGAGTGTGCTTGTCTGCTCCCGGCATTTTCGGCGGCTCGACTTTAATACCATACGCAATGGAAAGTACTTGCTGAAGCCGCGCGTGTTTCCCACTGTCTTTCCGTGGGGAAAAATGGAACCGTCTGAGATTGAGGCTGATCATCGTGCCCTGCAACAGGCTACAGTAGATGGCAGTGCAGCCAGTGGTGCGGCCAACAGCTCATCTACCGAAGACGTCATCAAGGCAACTGTTGACCAAATTGTAGCCCAAATCTTGGCCGAAACAGCCGAGCgaaatgcagctgctgcagccgctgctgctgctgttgcggcggCAGCCAAAGCCCAAGAAGATGCCTCAGAAAGTTCTCAGGACACACCTGTTGAAACAGCAGCCGCTAAAAGTGCTGATGAGAGCACTGAAAGTACTTCTCTCGAGATGGAAGCTGGTTCATCAGACACAGCTATCGAAACACCAGCAGCTGGAAATAGCGACAATTCGCCATTGGTAGCAACGCCACCCAAATATTGCTCGCCCACGAACATGACGATTGGAGCGCGTCTCGAAGCACTGAGTGTCGATGGGGTCTGGTGGCCAGCACGGATCGTTGAGGTCAACGAGTCTGAGCAGACGATGCTAATACGCTTCGAGCGCAATAGCAAGCTAAAGGTGTCACCATCCACGAGCGGCAGCTATCAGGAATGGATTGCCTGTAAATCAGATCGTTTGCGTCAGCGCATAAGTTCACGCATTGTGCCCGTTTTTGAGCTGGAAGAGAAGTGCATGGCGCGTTGGTCAGGACCACGTAAATTTCCGGGAACCATCAAAAAGCTACTGGGCAATGATACCTACGAGGTACTCTTTGATGACGGCTACACCAAGAATGTGCGCGGCGTGCACATGAACAAGCTACCACGTCAGCTGTCGGCCACAGCTGAGATCAACCTAGAAACCACAAACAGTTCAAGTAACGATTCGGTTGCGggcccagctccagctccagctccagctccaactccagttACAGTTTCAGCACCACTTAAAAGGCCAAGCACTGGCGGCACAAGTAGCAccaagaaaagcaaaacagcGCCACAGCGCAAGGATTGGCCTCTATTGGACATGACCACTTTGAATTTGGGATCATTGGGGCTACCCGATATACCACACGATGGAGAATGGACCTGCCACTGGGTAAATGATCAGCCGATTGGCAGCGAGGGATTTCTTATTGTCGGCGAGCACCAGAAGCCAACGGTGATTGTCCATGACTGGCGATTGCCGGCAGGCTGGATAAAGCACATGTATCAACGCTCCAATGTGCTGGGCAAGTGGGATGTGATATTGGTCTCGCCCAGTGGCAAACGTTTTCGCTCAAAATCCGATTTAAAGGTGTTTCTGGAGGCGCagggctatatatataacccgGATGTGTATGACTTTAGCATTCATCGCCGTCGCGCCAAGGACATTGGTGCATATGTCTATACACACGACTACACTCCGCAGCAGGCGTTTAAACCGAAGTCACTAGATGTGTCCCTAGACACCACGACCACTTCGCAGGAtgcaaacagcagcaagcTGTCTACGGCTACACCAACGTCTACATCCATAACGGCAATGTCTACGCGTCGTGCTGCAGCGGAAGAAAGTCAGTACATGGAGACGCCAGTTGCTTCATTGGTGCCACCGGCAGAGTTGATGTCACCATCGCCGCATGGTCCCACTACGGATGCGAACATTACAGCCGAAGGTAACGCGGATGAGCATGGCGCAGTGGTAGTTGAAGATGGTTACGCTTTTATTGGCGGATTAAAGGTACAAATAACAGATAATCTGTTTGTGTGCCCACGTGAAGGATGCGGTAAAACCTACCGCAAGGAAGATTTTCTCCAAATACACATCAGACATTACCACAAAGAATTCGCACAACATGTCAGTCACTGTCCCAAGATGCAGGAGCTGGCAGTTAAACGCACGCATCCCTCGTCAATTGAGCAGAGCGAGCATAcacccaaaaaccaaataccCAACCAACAGTTCTTTGCCAAGTTGCACCAACAGGATTTACAGCAATCTCGCTCTTTTCGACGCCAACCAGCGGGCCCGGAATCATCGCCAATGGCTATTGAAACAACCCCAAATATTTCGCCCATTAAATCTATGCTGTCACCCAAAACAgagacaccaacaacaacagggacGTTGCCGCAGCCTTTGCCTAGGGCACTAGAGGCTGTTGTGGCAGCTAGTGTAGCATCGCCAACTCCGTCAAGGACACCAACTCCACTGGAATCCTCTAAATCAAGCACACCAGCCGCTCCATCGTCATCCAGTCGCTCAGCCAAACGTTCGCGTCCTTCATCCAGCAAAAGACAGTCTGGTTCACGTAAGAGCAGCCGTCAACGCACACGTCGCTATGCAAATGTATCGCAAAAGAAAGTTCCGGCTGCCGAAAGCACGCCAAAAGTTCCGGTGTCCGATGCTGAGAACGAGGAGACGCGAGCGTCATTAAAAGCTGTTACACCGGAGGTGCGAAACGATGCCAAGCGTCGTATAGCTCTAACGGGTACGCCGATTAGCTCGCCTGCCCACATTGATTCTGTGTCAACGCCATCGTCTATAGATCAGGTGGACATAAATGCAGCATTggcgccaccgccaccacaaATGCCCAGTCAGACGCCACAATACATAAAGGAGAACGGCGAATTGATTCGCATTGTACGCATGAGGCAAGAGGAGATTATCAATTGCATTTGCGAATATGGTGAAGAGGATGGCCTAATGATACAGTGCGAGCTATGCCTGTGCTGGCAGCATGGAGCCTGCAATGGCATTGTCAAGGAGGCAGATGTGCCGGAAAAATATGTGTGCTATATTTGCCGTAATCCTCAGCGGGTGCGGGAGTCGATGCGCTTTAAACACGATCAGGATTGGTTATTCGAGGGCAAGCTACCTGTGGCTGGCTATCACACACCCAACCCACAGTCGGCAAAGAAGTTTGAGCAATTGAAGCGTTCCCATACGCTAACTGGCAATCTGCTGGATGCAAAGCGTTCCATGCACTCGTTGCTGGTCAAGATAAATATTGCTCGCAATCGGTGCCATCCCAAGCTCTATCTGTGGGCCAAGAAATGGGACGAAGATCAGGTTGACAACTCTGCCACACCCGTAAAGCGGCCAAAGACCGAAAAGCCCGACTGGCCACATGTACCCCAACCAGAGGCTGCTATCGATCCTGAGGAATGCCAGTATCGCTTAATAGAGCACGTCAAGATACAGCAATCTCTGCTGCTGAATCGCCTCAACGATATCGAAGCCGAAATCAATGaaCTCGAAAAGGAGGACACTTTGGCTGATCTTAAAGACGCAGACATTTCCACAACCAAAGAAGCCATGGCCACGTTTATTAAAGAAATGGAGACACTAAAGCGCCTTGCCAAGCTCAACAAAGTTGCGAATATGAAGCAGGCTCTAAaggaacaagaacaacaatccACAACAATTCCAGAGACAACTCCAAATTAA
Protein Sequence: MGRRCCVAECPSTSRLLEHHGVTYHSFPMDAVIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMEPSEIEADHRALQQATVDGSAASGAANSSSTEDVIKATVDQIVAQILAETAERNAAAAAAAAAVAAAAKAQEDASESSQDTPVETAAAKSADESTESTSLEMEAGSSDTAIETPAAGNSDNSPLVATPPKYCSPTNMTIGARLEALSVDGVWWPARIVEVNESEQTMLIRFERNSKLKVSPSTSGSYQEWIACKSDRLRQRISSRIVPVFELEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYTKNVRGVHMNKLPRQLSATAEINLETTNSSSNDSVAGPAPAPAPAPTPVTVSAPLKRPSTGGTSSTKKSKTAPQRKDWPLLDMTTLNLGSLGLPDIPHDGEWTCHWVNDQPIGSEGFLIVGEHQKPTVIVHDWRLPAGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLEAQGYIYNPDVYDFSIHRRRAKDIGAYVYTHDYTPQQAFKPKSLDVSLDTTTTSQDANSSKLSTATPTSTSITAMSTRRAAAEESQYMETPVASLVPPAELMSPSPHGPTTDANITAEGNADEHGAVVVEDGYAFIGGLKVQITDNLFVCPREGCGKTYRKEDFLQIHIRHYHKEFAQHVSHCPKMQELAVKRTHPSSIEQSEHTPKNQIPNQQFFAKLHQQDLQQSRSFRRQPAGPESSPMAIETTPNISPIKSMLSPKTETPTTTGTLPQPLPRALEAVVAASVASPTPSRTPTPLESSKSSTPAAPSSSSRSAKRSRPSSSKRQSGSRKSSRQRTRRYANVSQKKVPAAESTPKVPVSDAENEETRASLKAVTPEVRNDAKRRIALTGTPISSPAHIDSVSTPSSIDQVDINAALAPPPPQMPSQTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPEKYVCYICRNPQRVRESMRFKHDQDWLFEGKLPVAGYHTPNPQSAKKFEQLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDQVDNSATPVKRPKTEKPDWPHVPQPEAAIDPEECQYRLIEHVKIQQSLLLNRLNDIEAEINELEKEDTLADLKDADISTTKEAMATFIKEMETLKRLAKLNKVANMKQALKEQEQQSTTIPETTPN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00806006;
90% Identity: iTF_00806006;
80% Identity: iTF_00806006;