Hhis006328.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Hirtodrosophila histrioides
Gene Symbol
bin
Assembly
GCA_037075165.1
Location
JBAMCL010000365.1:763445-767261[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.2e-34 2.7e-31 107.7 0.0 1 87 326 413 326 414 0.95

Sequence Information

Coding Sequence
atgattaaaagtGAAGAAGTTGTGTCTGATTTGAATAGTCGGAACATGGGCGTTGATCAGTTGGGCGGCTTTGTGTCCGCATCGCActatcaccatcatcatccgCACCATCATCTGGCCACAcagcatcctcatcctcatccccatccccattcACACCCACATGCACATACGCTTCCGCATCACACCTCCTCGCATTTGTATCGCGGTGGGAACTTTTTGCCTGCTGGCAATTTCCAATCGATGGGTGGCGATTCACCCACCGAGCTGGTGGATGAGAAGCCCAACATTAGCTACATGGAGCGCAAGTACTATGCCTCTGCGGTGGATGCCTCTGGCAATGTCACGCCCACAAACCAACACTATGGGCTGAATGGACTGCACAGTATGGGCACACCGCCGGCATCGTCAAGTCCGATTCCACCGTACAGCGTGCTAATGACGACCCACTCGGCGGGCTCGATATCGCCCAATTCCAGCTCCAAGACGCCCACCGATCAGGAGATGTATGTGAGCTCCTCGGTGGTGaagccgctgcagctgcagccgatgAATCATCAGTATGCCTCCACCATCAAGTACTGCTCCAACAATACCATACTGAGCGCCAACGACTACCATCAGCTGGCCATGCACGAggcggagcagcagcagcagcaacagcaacagcagcagcaccactcCCAATCCCAGTCACagtcccagcagcagcactctCCGTCGGCGGGATCCTATCTGCCCCGCATCGCCTCCTCGCCTACACAGATCATTTCCAATGCCCATGGCCACGGCATGTCCGTGCTGAACTACTCGAGTGCGAGCTCATCGCCTGCCAAGTCCTTGAATGGCTCTGAATCCACGCCAATAAACACGGTTCATGCCAGCTCAAACGGACAACAGTCCAAGGCGAGTGGGGCCAGTACTCAGGATAGTAGCACACCGGATACGACCAAGAAATCTGGCACTCGTCGTCCGGAAAAGCCAGCTTTAAGCTACATAAACATGATCGGACATGCCATCAAGGAGTCGCCCACTGGCAAACTGACTCTCAGCGAGATCTATGCATATCTACAAAAGAGCTATGAATTCTTTCGCGGACCCTACGTGGGCTGGAAGAACTCGGTGCGGCACAATCTAAGCCTGAACGAGTGCTTCAAGAAGCTGCCCAAGGGCATGGGCGTTGGAAAGCCGGGCAAGGGCAACTACTGGACCATTGATGAGAATTCGGCCCATTTGTTCGAGGATGAGGGCAGTCTGCGCCGTCGTCCTCGCGGCTATCGCTCCAAGATCAAGGTCAAGACGTATGCCGTCACTGCCAATGGCTTTTACAACGGCAGCTACGGCGATGCGGGCATGGACAATGCCAATTTCTATGCAACGCCCGCGTATGCCAGCTATGATTACGGCGCCGCTGGCGTTCCCAATGGCGTTTCTTCGGCGGCTCAGGGCTTTGGTGATGCTTGGAACGTGCATGCGGCGCACAGTGGTGCCACAGCCATTGGCGTGGGTACCCTGCCGCAGTACTCGAACATAACCTGCCTGACGGCGGTGGGCAACAATCTGAATGGCTCACCAACGCCACCGCTGGCTCACTCTGCGCTGGGCATGACCTCGACGGCGGGCTCCTCCAGTTCGCCCGTGGCGGTGCTTCAAAGCGATTATGCGCCAGCCGCCAGTCTCGTGGCGGCGGGTTACCCCTATGCAACAAGTGGCAGTGGCTTGGATAACGGTCTGCGCTCCATgtcgctgcagcagctgcccgcCTTGCCCTCCATTCAGTCGGGTCAGtcgcaatcgcaatcgcaatcgcaatcCCAGTCCCACCAccatcaccaccaccaccatcatCATGGCACGATGACACCGCCGCCATCACAGTCGGGCAACCACGGTATTGATCGATCTCCCATCGATCTGAAACCGGTTTACCTGCCGCCCATAACTCCGCCCCCCACTTCGGTGAATGGGGGCTACTATGAGacaatcaaatattcaaattag
Protein Sequence
MIKSEEVVSDLNSRNMGVDQLGGFVSASHYHHHHPHHHLATQHPHPHPHPHSHPHAHTLPHHTSSHLYRGGNFLPAGNFQSMGGDSPTELVDEKPNISYMERKYYASAVDASGNVTPTNQHYGLNGLHSMGTPPASSSPIPPYSVLMTTHSAGSISPNSSSKTPTDQEMYVSSSVVKPLQLQPMNHQYASTIKYCSNNTILSANDYHQLAMHEAEQQQQQQQQQQHHSQSQSQSQQQHSPSAGSYLPRIASSPTQIISNAHGHGMSVLNYSSASSSPAKSLNGSESTPINTVHASSNGQQSKASGASTQDSSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPRGYRSKIKVKTYAVTANGFYNGSYGDAGMDNANFYATPAYASYDYGAAGVPNGVSSAAQGFGDAWNVHAAHSGATAIGVGTLPQYSNITCLTAVGNNLNGSPTPPLAHSALGMTSTAGSSSSPVAVLQSDYAPAASLVAAGYPYATSGSGLDNGLRSMSLQQLPALPSIQSGQSQSQSQSQSQSHHHHHHHHHHGTMTPPPSQSGNHGIDRSPIDLKPVYLPPITPPPTSVNGGYYETIKYSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00583489; iTF_01355942; iTF_01570055; iTF_00616715; iTF_00505922; iTF_00526388; iTF_00534394; iTF_00597965; iTF_00533614; iTF_00562991; iTF_00802646; iTF_00803414; iTF_00495672; iTF_00805779; iTF_00582076; iTF_00490594; iTF_00530767; iTF_00550741;
90% Identity
iTF_00803414;
80% Identity
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