Hhis000268.3
Basic Information
- Insect
- Hirtodrosophila histrioides
- Gene Symbol
- ewg
- Assembly
- GCA_037075165.1
- Location
- JBAMCL010000013.1:2202497-2208858[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 3.9e-108 2.7e-104 347.7 0.0 1 212 47 257 47 258 0.98 2 5 0.32 2.2e+03 -1.7 1.8 91 111 363 383 332 422 0.58 3 5 0.18 1.3e+03 -0.9 0.4 12 121 446 469 432 494 0.52 4 5 1.1 7.9e+03 -3.5 0.4 103 133 745 775 725 792 0.54 5 5 2.8 2e+04 -4.8 1.6 6 15 803 812 799 814 0.83
Sequence Information
- Coding Sequence
- ATGCTCGAGGATGATATACAGAGTCTGGCCACCGATGAGGATGACGATGACTTAATTAGCAGCGAGGGCAGCTTATACGATGGTGATCTCAATACAATAGCCGTTAACGATGATGTTGCCCATCAGCTGGCCGCCGCCGGGCCAGTGGGCGTTGCAGCGGCCGCTGCCATTGCCAGctcaaagaaacgcaaacgtcCGCACTGCTTTGAAACGAATCCCTCGGTCCGCAAGCGTCAACAGAATCGCCTGCTGCGCAAACTACGTGGCATCATCTATGAGTTCACGGGACGTGTGGGCAAGCAGGCGGTGGTGCTGGTTGCCACGCCGGGCAAGCCGAATACCAGCTACAAAGTTTTTGGCGCCAAGCCGCTGGAGGATGTGCTGCGTAATCTGAAGAACATTGTGATGGATGAGCTGGACAATGCATTGGCGCAACAggcgccaccgccgccgcaaGAGGATCCATCGCTGTTTGAGCTGCCCGGTTTGGTTATTGATGGCATACCCACGCCCGTCGAGAAGATGACACAGGCGCAACTGCGCGCTTTCATACCGCTGATGCTGAAGTATTCAACGGGACGTGGGAAGCCCGGCTGGGGCAGGGAGTCGACAAGACCGCCGTGGTGGCCCAAGGAGTTGCCCTGGGCGAATGTGCGTATGGATGCCCGCTCCGAGGATGACAAGCAGAAGATTAGCTGGACACACGCGCTACGCAAGATTGTGATCAACTGTTACAAGTACCATGGTCGCGAGGATCTGTTGCCGACATTTGCCGACGATGAGGACAAGGTGAATGCTTTAATCTCACAGTCCGgcgatgaggatgaggatatGGAGCAGCTATCCAATACGCCCACCATACAGACGGTGCAAACGGTGGCACCACCAACCTCCACAGCCACTAGCCAACCACAGCAGGTGAATGTGGTTAAGATCAACAGCGCTGGAACTGTGATCACAACGCACACGGCGCAAACGAATTCACCAGCGCCAACAATTATCCAGAGCACCAACAATCAGCATATaaccacaacagcaacgcTGCCAGCATCcacaaaaatagaaatatgcCAGGCGCcagcgcaacagcagcagcaccaccaacagcagcagcagcagcaccaccaacagcaacagcagcaccatcaccaccaccatcaacagcagcagcatcatcagacATCAAGTGGCAGCAATACGGTTCACATACAGGCCGTCAGTCAGTCGCAGCCACAGACCATACAGTTGACAACCGCGAGCGGTACGGCAACGGCCACAGCTgtgccaacaacagcagccgctgTAAGTGCAtcagcggcggcggctgccgctgcggcagctgcacaacagcagcaacagcaacaacaatcaaatgcTGCACAAACCGTTACCGCCCAACAGATTGCCAATGCCCAAGTTTGCATCGAGCCCATAACGCTCAGCGACGTTGATTACACCACACAGACTGTTTTGTCGCAGAACGCCGATGGTACCGTATCTCTCATACAGGTTGATCCAAACAATCCGATCATAACGCTTCCAGATGGCACTACCGCTCAGGTGCAGGGTGTGGCAACGCTGCATCAAGGAGAGGGTGGCGCCACCATACAAACGGTACAAAGCTTAACAGATGTTAATGGCCATGAGAACATGACTGTAGATCTAACCGAGGCTCAGGATGGCCAGATCTTTATCACCACCGAGGATGGACAAGGCTATCCGGTCTCCGTGAGCAATGTGATCTCGGTGCCCGTTTCCATGTACCAGTCGGTGATGGCCAacatgcagcagctgcagacgAACAGCGACGGCACTGTGTGCCTGGCCCCCATGCAGGTagataacagcaacaactccaGCTCTTCCAATAGCGCAAcgcgcaacagcagcaacaacaacaacagtagcagcagcagtaataataacaacaacagcagcagtagcggCAGCAGCACAGCTGCTGCGTCAGCTTCGCTGCTTGGGATCTCGGTGATCAATGCTGGCGCTATGCTAGGCCGACGCATtgctggcagcggcagcgctgcCGCAGCGTCAAATGGCGGCCAACAGGCAGCGTTAACATTGCAGGCGCCACCGGGCACGCGGTTATATTGGGCGCCAAGTCCTGcgggcggcggcagcggcagcgtcgGTGGCACAAGCTTTAATCTCGCtaacaataatagcaatagcaataataataataataataataatagcatgcttactaacaataataacaacaacaacaataacattaaaaTGCCGCTGCCCATTGTTTTAACAGCGCCTGTTGCGTCGACTGCGCAGCGACGCAATGAGACAAATGCATTGCGGCGCACTACAGCAGCGCAGCAAAAGCGACGCAAACTgcatagcaacaacaacaacaagaatgttaacgatgctgctgcggctgctgttgttacaGGCAGCGCCGCTGCGGCCATACGCTGCGTTGACAGCGCCAGTTTAACAAATACGAGCAGCGCAACGCCGGTGCCGGCGTCGCTGCCAGCCAAAATCATTAAATTAGAGCATTTTGAGTAG
- Protein Sequence
- MLEDDIQSLATDEDDDDLISSEGSLYDGDLNTIAVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVAPPTSTATSQPQQVNVVKINSAGTVITTHTAQTNSPAPTIIQSTNNQHITTTATLPASTKIEICQAPAQQQQHHQQQQQQHHQQQQQHHHHHHQQQQHHQTSSGSNTVHIQAVSQSQPQTIQLTTASGTATATAVPTTAAAVSASAAAAAAAAAAQQQQQQQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLQTNSDGTVCLAPMQVDNSNNSSSSNSATRNSSNNNNSSSSSNNNNNSSSSGSSTAAASASLLGISVINAGAMLGRRIAGSGSAAAASNGGQQAALTLQAPPGTRLYWAPSPAGGGSGSVGGTSFNLANNNSNSNNNNNNNNSMLTNNNNNNNNNIKMPLPIVLTAPVASTAQRRNETNALRRTTAAQQKRRKLHSNNNNKNVNDAAAAAVVTGSAAAAIRCVDSASLTNTSSATPVPASLPAKIIKLEHFE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00594986;
- 90% Identity
- iTF_00803342;
- 80% Identity
- -