Basic Information

Insect: Hirtodrosophila confusa
Gene Symbol: ewg
Assembly: GCA_035043065.1
Location: JAWNNI010000085.1:1253168-1258802[+]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 3.8e-108 3.2e-104 347.7 0.0 1 212 47 257 47 258 0.98

2 4 0.39 3.3e+03 -2.0 1.1 87 112 359 384 332 420 0.54

3 4 0.094 7.8e+02 0.1 1.7 97 136 442 481 428 493 0.69

4 4 1.2 1e+04 -3.6 0.5 93 130 734 771 723 787 0.55

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	3.8e-108	3.2e-104	347.7	0.0	1	212	47	257	47	258	0.98
2	4	0.39	3.3e+03	-2.0	1.1	87	112	359	384	332	420	0.54
3	4	0.094	7.8e+02	0.1	1.7	97	136	442	481	428	493	0.69
4	4	1.2	1e+04	-3.6	0.5	93	130	734	771	723	787	0.55

Sequence Information

Coding Sequence: ATGCTCGAGGATGATATACAAAGTCTGGCCACTGATGAGGACGATGATGACTTAATTAGCAGCGAGGGCAGCTTATATGATGGTGATCTCAATACAATAGCCGTTAACGATGATGTTGCCCATCAGCTGGCCGCCGCTGGGCCAGTGGGCgttgcagctgccgctgccattgcCAGCTCAAAGAAACGCAAACGTCCGCACTGCTTTGAAACGAACCCCTCGGTCCGCAAGCGTCAACAGAATCGCCTGCTGCGCAAACTGCGTGGCATCATCTATGAGTTCACGGGACGTGTGGGCAAGCAGGCGGTGGTGCTGGTTGCCACGCCGGGCAAGCCGAATACCAGCTACAAGGTGTTTGGGGCCAAGCCGCTGGAGGATGTGCTGCGTAATCTGAAGAACATTGTTATGGATGAGCTGGACAATGCATTGGCGCAACAggcgccaccgccgccgcagGAGGATCCATCGCTGTTTGAGCTGCCTGGACTGGTTATTGATGGCATACCCACGCCGGTGGAGAAGATGACACAGGCGCAGCTGCGCGCCTTTATACCGCTCATGCTCAAGTATTCAACGGGACGTGGCAAGCCCGGCTGGGGCAGGGAGTCGACAAGGCCGCCGTGGTGGCCCAAGGAGTTGCCCTGGGCGAATGTGCGTATGGATGCCCGCTCCGAGGATGACAAGCAGAAGATTAGCTGGACACACGCGCTGCGCAAGATTGTGATCAACTGTTACAAGTACCATGGGCGCGAGGATCTGCTGCCGACATTTGCCGACGATGAGGACAAGGTGAATGCATTAATCTCACAGTCCGgcgatgaggatgaggacaTGGAGCAGCTATCCAATACGCCCACCATACAGACGGTGCAAACGGTGGCACCAGCAACCACCACAGCCACTAGCCAAccaCAGCAGGTGAACGTGGTTAAGATCAACAGCGCTGGAACAGTGATCACAACGCACACGGCGCAAACGAATTCACCAGCGCCAACAATTATCCAGAGCACCAACAATCAGCATATAACCACAACAGCAACGCTGCCAGCATCCACAAAAATAGAGATATGCCAGGCGCCagcgcaacagcagcaccaccaacagcagcagcaacagcagcagcaccatcaccaccaccatcaccatcagcagcagcatcatcatcagacATCAACTGGCAGCAATACGGTCCACATACAGGCCGTCAGTCAGTCGCAGCCACAGACCATACAGTTGACCACCGCCAGCGGTACGGCAACGGCCACAGCtgtgccaacaacagcagccgctgTAAGTGCATCAGCGGTGGCGGCTGCCgctgcacaacaacagcagcagcaacaacaacaacaacaacaatcaaatgcTGCACAGACCGTTACCGCCCAACAGATTGCCAATGCCCAAGTTTGCATCGAGCCCATAACGCTCAGCGACGTTGATTACACCACACAGACTGTTTTGTCGCAGAACGCCGATGGTACCGTATCTCTCATACAGGTGGATCCAAACAATCCGATCATAACGCTTCCAGATGGTACAACCGCTCAGGTGCAGGGTGTGGCAACGCTGCATCAAGGGGAGGGTGGCGCCACCATACAAACGGTACAAAGCTTAACAGATGTTAATGGCCACGAGAACATGACTGTGGATCTAACCGAGGCTCAGGATGGCCAGATCTTCATCACCACCGAGGATGGACAAGGCTACCCGGTCTCCGTGAGCAACGTGATCTCGGTGCCCGTTTCCATGTACCAGTCGGTGATGGCCAacatgcagcagctgcagacgAACAGCGACGGCACTGTGTGCCTGGCCCCCATGCAGGTagataacagcaacaactccAGCTCTTCCAATAGCGCAacgcgcaacaacaacaacaacaacaacagtagcagcagtaataataacaacaacaacagcagcagtagcggCAGCAGCACAGCTGCTGCGTCAGCTTCGCTGCTTGGCATCTCGGTGATCAATGCTGGCGCTATGCTGGGCCGCCGCATtgctggcagtggcagcgctgccgcaGCGTCAAATGGCGGCCAACAGGCAGCGTTAACATTGCAAGCGCCACCGGGCACGCGGTTATACTGGGCACCGAGTCCTGCGGGcggcggcagtggcagtggcagcgtcGGTGGCACAAGCTTTAATCTCGCTAACAATaatagcaatagcaataataataataataatagcatgcttactaacaacaataacaataataacaacaacaataacattaaaatGCCGCTGCCCATTGTTTTAACAGCGCCTGTTGCGTCGACTGCGCAGCGACGCAATGTGACAAATGCGTCGCGACGCACTACAGCAGCGCAGCAAAAGCGCCGCAAACTGCatagtaacaacaaaaatgttaacgatgctgctgcgactgctgctgtttcAGGTAGCGCCGCTGCGGCCATACGCTGCGTCGACAGCGCCAGTTTAACAAATACGAGCAGCGCATCGCTGCCGGCGCCGCTGCCAGCCAAAATCATTAAATTAGAGCATTTTGAGTAG
Protein Sequence: MLEDDIQSLATDEDDDDLISSEGSLYDGDLNTIAVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVAPATTTATSQPQQVNVVKINSAGTVITTHTAQTNSPAPTIIQSTNNQHITTTATLPASTKIEICQAPAQQQHHQQQQQQQQHHHHHHHHQQQHHHQTSTGSNTVHIQAVSQSQPQTIQLTTASGTATATAVPTTAAAVSASAVAAAAAQQQQQQQQQQQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLQTNSDGTVCLAPMQVDNSNNSSSSNSATRNNNNNNNSSSSNNNNNNSSSSGSSTAAASASLLGISVINAGAMLGRRIAGSGSAAAASNGGQQAALTLQAPPGTRLYWAPSPAGGGSGSGSVGGTSFNLANNNSNSNNNNNNSMLTNNNNNNNNNNNIKMPLPIVLTAPVASTAQRRNVTNASRRTTAAQQKRRKLHSNNKNVNDAAATAAVSGSAAAAIRCVDSASLTNTSSASLPAPLPAKIIKLEHFE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00594986;
90% Identity: iTF_00804923;
80% Identity: -