Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0018 9 6.7 0.0 23 44 66 87 60 92 0.89

2 7 0.00068 3.4 8.0 0.2 21 45 92 116 87 120 0.87

3 7 0.014 68 3.9 0.2 18 44 117 143 116 147 0.87

4 7 0.00054 2.7 8.3 0.4 21 45 148 172 145 179 0.90

5 7 0.082 4.1e+02 1.4 0.4 21 44 204 227 196 230 0.79

6 7 0.00017 0.87 9.9 1.0 21 47 232 258 226 265 0.88

7 7 0.00015 0.75 10.1 0.8 20 45 287 312 271 319 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0018	9	6.7	0.0	23	44	66	87	60	92	0.89
2	7	0.00068	3.4	8.0	0.2	21	45	92	116	87	120	0.87
3	7	0.014	68	3.9	0.2	18	44	117	143	116	147	0.87
4	7	0.00054	2.7	8.3	0.4	21	45	148	172	145	179	0.90
5	7	0.082	4.1e+02	1.4	0.4	21	44	204	227	196	230	0.79
6	7	0.00017	0.87	9.9	1.0	21	47	232	258	226	265	0.88
7	7	0.00015	0.75	10.1	0.8	20	45	287	312	271	319	0.83

Coding Sequence: ATGCAGACGGACGAAGACCGTATATGTGTTAAGGCAGAGCCCGTAGAGGTTGAAGATGGATTTGGAATGCTAGTGCAAGGGGAAGTGGAGCAGGAGCTTCAATCAGACATAGATATAGGCTGCGTAAAAATTGAAGGAGAGGGAGATGAAGATGAGCCAATAAATGCGAGCACTGTACAGTTCGATTTGGAATCCAATCCAGCAACATGCTCTGTATGTGGCTTGGACTGCAAGAAGAAGTACAATCTGAAGCTTCACATGCGCACGCACACTGGAGAAAAGCCTGTGAGGTGTCCCCACTGTTCCGCGTCGTTTGCGCGCCACGACAACTTCAAGACACATCTACGCCGGCATACTGGCGAACGGCCCCACAAATGTCCGGAGTGCAGCAAAAACTTTCTAACGCCCAGCGACCTCAAACGCCACATTCACACTCATACTGGCGAAAAACCTTACCAGTGCCCCCACTGCCCGAAGGCATTTGCCCAAAACCTTAATCTCCGTGTGCACATACGAACCCACACCGGAGAACGGCCATACCAATGTTCCGACTGTCCAAAGACATTTCTGTCGGACAGCCATCTCAAGGAACACATGCGAGTTCATACTGGCGAGCGCCCTTACACTTGCACACACTGCGCCATGTCCTTTATCACTCACTCTAATCTGAACTGTCATATGCGCACACACACTGGCGAACGGCCCCACCAATGCCCGCACTGCTCAAGGACATTTGCCCAGCAGGCAAATTTTAATAAGCACCTCCAACTCCATACTGGCGAACGGCCCCACAAGTGCCTCGAGTGCAGCAAGAGCTTTCCGTCGCCCAGCGAGCTGAAGCGTCACATCAGGACGCACACAGGCGAACGACCCCACGCATGTCCGGTCTGTCCAAAAGCCTTTGGCCAGAAAAGTCAACTCAAGCAACACCTGCGAACGCACGCATCTGCGAGAGTCCactgcaaaatacaaaattaa
Protein Sequence: MQTDEDRICVKAEPVEVEDGFGMLVQGEVEQELQSDIDIGCVKIEGEGDEDEPINASTVQFDLESNPATCSVCGLDCKKKYNLKLHMRTHTGEKPVRCPHCSASFARHDNFKTHLRRHTGERPHKCPECSKNFLTPSDLKRHIHTHTGEKPYQCPHCPKAFAQNLNLRVHIRTHTGERPYQCSDCPKTFLSDSHLKEHMRVHTGERPYTCTHCAMSFITHSNLNCHMRTHTGERPHQCPHCSRTFAQQANFNKHLQLHTGERPHKCLECSKSFPSPSELKRHIRTHTGERPHACPVCPKAFGQKSQLKQHLRTHASARVHCKIQN

Sequence clustering based on sequence similarity using MMseqs2