Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00082 5.3 7.4 0.3 23 45 167 189 156 196 0.81

2 6 0.00091 5.9 7.2 0.1 22 45 194 217 189 221 0.86

3 6 6.4e-05 0.42 10.9 0.3 21 44 221 244 218 248 0.91

4 6 0.0094 61 4.0 0.2 21 43 249 271 245 276 0.88

5 6 0.00014 0.89 9.8 1.0 21 46 277 302 273 312 0.79

6 6 0.028 1.8e+02 2.5 0.3 22 49 306 332 301 335 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00082	5.3	7.4	0.3	23	45	167	189	156	196	0.81
2	6	0.00091	5.9	7.2	0.1	22	45	194	217	189	221	0.86
3	6	6.4e-05	0.42	10.9	0.3	21	44	221	244	218	248	0.91
4	6	0.0094	61	4.0	0.2	21	43	249	271	245	276	0.88
5	6	0.00014	0.89	9.8	1.0	21	46	277	302	273	312	0.79
6	6	0.028	1.8e+02	2.5	0.3	22	49	306	332	301	335	0.85

Coding Sequence: atGAAAGAACTTTGCCGGATTTGTATGAGTAGCTCTGTAACACTTGTGGAAATATTTGCAGAACGACCTCAAACGGAGGAGGAACCCAATATATCAGAAATGCTAAATGAGTGCGTTTCACAGATGACTGTCACACAGGATGATCCATTGCCAAAGCAGATTTGTCTATCGTGTGTTCTCGACGCTCAAAATGCATTCAGATTCAAGCGGCGATGCGAACGAAGCCACCAACGTTTTTGGAAACTCTTGAACGAAAGGGAACAGGATAACATTGAGGAATCCATCGGTCAAATTGTTGAAACTAATTTGCACCATGGAGAATATAGCATAGTCACAGACTACGTTAAGAAAGAGAAACTAGAGAATCGTGTGATGGATAGCTgggcaataaaaaaagaacttttaCCGGAGACGGATAATTGTAAAACTGATAGCGTAATTGAAAACGATAACGTTAAAGAGGCGTCTAACAGTATTGctaaaagtaaaagcaaagacCGCTTAAACAAATGTCCCTACTGTccgaaaattattaaacatcaCGCGAATTTTGAAAGACACATTCGCACACACGACGACGAGCGTTCGTTCGAGTGTCCTGAATGCTCAAAAACTTTCGCTCGAAGCCATAATCTCAAGAAGCACTTAATCATTCATACCGGAGAACGACCATACACTTGTCCCCACTGCTCAAAAACCTTTACCCAGCGTTCAAATCTTAATAAGCACATCCGCACTCATACTGGCGAGCGTCCGTACAAGTGTCCTTACTGTTCCAAAGCTTTTGTAGAGAGCCACCATCTGAAAAATCACACAATGTGCCATACCGAAGAGCGTCCGTTTACGTGTCCACATTGTCCAAAAGCCTTCATCAGAAGTATAAATCTAGAAACGCATCTTCGGGTTCATTCAGGGGACCGTCCATTCGCTTGCCCTCAATGCCCAAAGACTTTTAATTTGGCCACATGCCTGAAGGGGCATTTACGGCTACATTTCGGCAATCGTACACACAAGTGA
Protein Sequence: MKELCRICMSSSVTLVEIFAERPQTEEEPNISEMLNECVSQMTVTQDDPLPKQICLSCVLDAQNAFRFKRRCERSHQRFWKLLNEREQDNIEESIGQIVETNLHHGEYSIVTDYVKKEKLENRVMDSWAIKKELLPETDNCKTDSVIENDNVKEASNSIAKSKSKDRLNKCPYCPKIIKHHANFERHIRTHDDERSFECPECSKTFARSHNLKKHLIIHTGERPYTCPHCSKTFTQRSNLNKHIRTHTGERPYKCPYCSKAFVESHHLKNHTMCHTEERPFTCPHCPKAFIRSINLETHLRVHSGDRPFACPQCPKTFNLATCLKGHLRLHFGNRTHK

Sequence clustering based on sequence similarity using MMseqs2