Basic Information

Gene Symbol
su(Hw)
Assembly
GCA_035043045.1
Location
JAWNNH010000119.1:1536996-1539993[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00068 0.047 14.3 2.2 1 20 214 233 214 235 0.94
2 12 2.8e-06 0.00019 21.8 0.4 3 23 286 307 284 307 0.93
3 12 0.0096 0.66 10.7 0.1 1 23 313 335 313 335 0.97
4 12 7.6e-07 5.3e-05 23.6 2.5 1 21 342 362 342 363 0.95
5 12 3.3e-06 0.00023 21.6 0.6 2 23 375 396 374 396 0.96
6 12 0.00011 0.0073 16.8 5.3 1 23 407 429 407 429 0.99
7 12 8.2e-05 0.0057 17.2 0.9 1 23 435 457 435 457 0.97
8 12 1.7e-05 0.0011 19.4 0.8 1 23 463 485 463 485 0.99
9 12 2.1e-06 0.00014 22.2 3.1 1 23 491 513 491 513 0.98
10 12 0.00024 0.016 15.7 1.3 1 23 517 539 517 539 0.97
11 12 3.6e-05 0.0025 18.3 0.1 1 20 547 566 547 571 0.92
12 12 9.1e-05 0.0063 17.0 0.3 3 23 591 612 589 612 0.96

Sequence Information

Coding Sequence
ATGAGCGCCAGCAAACAAGTCGCCGCTGCGGCGCAAACAGCATCAACTTCCAGTTCTGGCTCAGTTATCAAAATACTGGATGTCAATCGACTGATGCCGAGAGAGAAGCGACCTGGCACACGCATGAAGCTACTAAACGATGTGGCTGCCAAGGCCGGAAAGCAGGAGAAGCGTCCAAGCATTAAAATACTCAATGCCGAAGAATTGTCAAACAGCCCAAAGGTGGGCAGCAGGCGATCCGCTGCGAAAACTGTTAGCCCCGCTGGCAATGCCGTAAAGATATTAAACGAGAAGCGCAATGCACCCGCTAGCACGCCCGTGGAAACTGCAAAGATTAAGACATCGCCGCCTGGTAAGAAGAAGAAAATGGATCACTACGTGCTGCAGGCGATCAAAAGCGAGAGCAGCAAATCTGACAACACCTCCACCATAGAGGTCGAGGACGACGatacaattgattttatactCGCCGAGAATGATGATCTTGAGCTGGGAGCGAACAAAACAAATGGCGACGAATTTGTTGTCTCTGGCGTTGACGAGGAGGACGAGGAGGAaaacgatgatgatgacaatgaAGATGAAGGCAGCCCAAGCCGCAACATcaccaacaacaacgacatcAAGGAAATGGTGGAGCATGTGTGCGGCAAGTGCTATAAGACATTCCGACGCGTCAAGAGTCTCAAGAAACACTTGGAATTCTGCCGCTACGACAGCGGCTATCATCTCCGTAAAGCGGACATGCTTAAGAATCTGGAGAAAATCGAGCGAGATGCCGTAGTCATGGAAAAGAAAGACATATGCTTCTGCTGCAGCGAGAGCTACGACACTTTTCATCTGGGCCACATTAACTGCCCTGATTGCCCAAAGTCATTTAAAACCCAGACTAGTTACGAGCGCCACATCTTCATTACTCACTCCGAGTTCAATGATTATCCCTGCTCCATTTGCAATGCCAAGCTGCGCAGTGCCGCTCTGCTCAAGCTGCACGAGCAGCAGCATCAGTCGCGTGGCAAGCCATTTGCCTGCAAGATTTGTGGCAAGGACTTTACGCGCTCGTACCATTTGAAGCGTCATCAGAAATACTCTTCGTGCTCGGCAAATGAGAATGATACCATGAGCTGCAAGGTATGCGATCGCGTCTTCTATCGCTTAGATAATCTACGCGCTCATCTGAAGCAGCATCTGGGCACTCAGGTGGTGAAGAAACCCGAGTACATGTGTCATGTGTGCAAGAATTGCTTTTACAGCTTGTCCACACTTAACATACACATACGCACCCACACGGGTGAAAAACCATTTGATTGCGATTTGTGCGACAAGAAGTTTTCAGCCTTGGTGGCACTCAAAAAGCATCGTCGTTACCACACAGGCGAGAAACCCTACACGTGCACGGTGTGTAGTCAATCCTTTGCCGTCAAGGAGGTGCTCAATCGTCACATGAAACGTCACACTGGCGAGCGTCCGCACAAGTGCACCGAGTGCGGCAAGAGCTTTATACAGGCCACACAGCTGCGCACGCATTCCAAGACGCATTTGCGTCCCTATTCCTGCTCGCTGTGCGTTCAGAAattcaaaacagaaaaacaACTTGAGCGTCACGTGAAGGAGCACACACGCCAGAAGCGTCCCACTTTCGCCTGCACAGAGTGTCCACGCAGCTTCCGCACCAGCGCACTGCTCAAGGAACACATTGACGCTGGTGATCATTCGCcTGTAAAACCAACTCGGGCCAAACGCACTGCCAAACTGATCGAGCGCACGGACTGCGCCATTTGCGACAAGAACTTTGACAGCACTGAGACCCTAAGAAATCACATACGCAATGTGCATGAATGCGATCCGGATGATATTTTTGGCACCGAGCCCCCGGCCGCCAAGCGTAGAGCCAAAAGGGCTAAGATTGTGCATGAGGTGGAGGAGGAAGAGAACAAGAaagatgatgacgatgagaTGGCGGCAGCTAATACATCAGCGGGCTCGCTCATTTCCAGCAAGACGGATGGCAATGGCGTTGTAGTGCGCGAATTTCTTGTGGATGAGGGTGACGGCAACGCTCAGACCATTGTGCTGGAGAACGAAGTCTATACCATTTTGCCTTTAGAAGGAGACGAGGCTGGCGAATCGGTCAAGCCAGAGTCTAAGGATAAGGAGAAGATAGTATCGCCGGTGGTTAAGAAGGAGCAGCGTAAATCACTGGCCGCCAGTTTGGCCGCTGCCATTGCTGACAATCTGGAGGAACCGTCTAGTGATGATGATTCTAATGGCGAATCGCTCACAGAGGAGGATCTAAAGCTCAAGGCAAACATAGCCAAATTAATTGACATGCTGGTCGATCCGCAGACACTCAAGAAATATAACTGGCCCAACAGCTCCGAGGAGACGGTGCTCTGCAAAGTCATTGAGAATTGTGGACACGATCTGGCCAAGGCTGGCGAGAACTATGCTGAGTTGGACTATGGCAGCCGCATGCGAGAATATTGCAAGCTTCTCTTCACAGTTGTCATACACAATGATTCCATTAAGTCCTTACTCAACAATTTTCCGATTGATGATGTTATCGAATATGTGTTGGGTGATGAGGATCAGGAAGAGGACGGAGAGCCCGATAAGGACAAAGACAATGAGTCGGTTAAGTCCGATACAGACAGCATTGTGGATGCCGTTAAAGTCAAGGCTTAA
Protein Sequence
MSASKQVAAAAQTASTSSSGSVIKILDVNRLMPREKRPGTRMKLLNDVAAKAGKQEKRPSIKILNAEELSNSPKVGSRRSAAKTVSPAGNAVKILNEKRNAPASTPVETAKIKTSPPGKKKKMDHYVLQAIKSESSKSDNTSTIEVEDDDTIDFILAENDDLELGANKTNGDEFVVSGVDEEDEEENDDDDNEDEGSPSRNITNNNDIKEMVEHVCGKCYKTFRRVKSLKKHLEFCRYDSGYHLRKADMLKNLEKIERDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFNDYPCSICNAKLRSAALLKLHEQQHQSRGKPFACKICGKDFTRSYHLKRHQKYSSCSANENDTMSCKVCDRVFYRLDNLRAHLKQHLGTQVVKKPEYMCHVCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYTCTVCSQSFAVKEVLNRHMKRHTGERPHKCTECGKSFIQATQLRTHSKTHLRPYSCSLCVQKFKTEKQLERHVKEHTRQKRPTFACTECPRSFRTSALLKEHIDAGDHSPVKPTRAKRTAKLIERTDCAICDKNFDSTETLRNHIRNVHECDPDDIFGTEPPAAKRRAKRAKIVHEVEEEENKKDDDDEMAAANTSAGSLISSKTDGNGVVVREFLVDEGDGNAQTIVLENEVYTILPLEGDEAGESVKPESKDKEKIVSPVVKKEQRKSLAASLAAAIADNLEEPSSDDDSNGESLTEEDLKLKANIAKLIDMLVDPQTLKKYNWPNSSEETVLCKVIENCGHDLAKAGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQEEDGEPDKDKDNESVKSDTDSIVDAVKVKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00569117;
90% Identity
-
80% Identity
-