Basic Information

Gene Symbol
Klhl22
Assembly
GCA_028554975.1
Location
JAHFWI010000007.1:7580814-7591746[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0031 1.3 9.8 0.0 6 30 130 154 126 157 0.91
2 4 3 1.3e+03 0.2 0.0 63 108 177 225 173 227 0.82
3 4 2e-16 8.8e-14 52.2 0.0 23 107 668 754 657 757 0.90
4 4 0.3 1.3e+02 3.4 0.0 80 108 760 788 754 790 0.88

Sequence Information

Coding Sequence
ATGGCGGCCTATTCGTTCATCGGTACTTGGGAAATAGAAACATGTTGGATACAAGGAAACTATGGCGTCGATTCAGAATTAGAAGGAACAAAATTTGTGCTAGACGATACGGGGGATGTTACGTGGTGCCCTGAAAATGAAGAAACTTCCAATATTCCACTATTCTCTTGCGAAACTTATGAAATTTACAGTACCAATATCCATGGAGCGATTGTTAGATTTGGAGCATATGGGGAACACATAATAGAGTTCAGAGCTGAACCGTCTCAACCTGTTGACAACCTCGTTCTTTCCTGTGAAGGCTGGTGTGTCTTACACTGTGTGCGAGTAACAAATGATGAACCGGATTGCAACCCTATTGAGGGTTTCAGCCTGCTACCTGCTGTGGAGGATGGATTTTTCTCTGACATGGTCATCGAAGCACAAGACAATAAGCAGTTTCACGTCCATTCGAGTATATTGGGGCTACTTGGCACAGATATGTCATGGATGAGAGACCCTCCTCCTTTTTCTGGATTACCGGAAGGTGTCGTCGGATCCATACTGCATTGGCTCTACGCCGAATGTCTCCCTAATGCGATGACAGAAGATCTCGCCATGCAAGTCATAGATGCCGTGAAAGAGTACCCCTGTATGTTGAAACTTGTAGACGACTGCAAAGTTTACCTTAAGAATATGGCCTTAAAGCAGCAAATAGTTGAATTAGTGAGTGATATGCACACTTCTGCAAATCAAATTATAGAATATTTTAATACGCCTGGTGAGTGTTTGGGATGTCATCCAGCTAAATTGTGCCTAGTTGTAAAACAATCCGTAAGGGAGACGGCAGTAGCCGTAGCCAAGCTCCTGCTCCTGTGCGAGTTGTTTTCAAAACGGAAGAATGAACTTTCGAGAGAAGAGAGACACGAAGTTATTCGATACGCCCGATCTAGATTACCAATTTTCATGTGTCAGCTGAGAAAACTTTTAGAGTCATTGAAAATTACATTCAGCTCGATGACGCCAGCTCAGCGACAGGAAGTCGCCACATATCTTGTTCCTGAGATAGAAGCAATATTAGACACTATTTCTGCGCTAATATTTGAGGTGAAGACAGCTCTTGAATTGATAATGCAAGCTCTGACTCCTGCAGAAGGCACCGACAAATGTGACCCTTCGGTATCTGGGAAAGCGACCCGGGACGCGTTGGGAAAATCTCTGCGCAATGTGTTGAGAATAAGAGAACTCGCCAAGCTCAAAAATTTTCACCAAAAAGTCACGTTTAGTCTAATGCATTTACTACATAAAAAAGAAAGTTTTGCTGAGATGAGTGACAGTAACAGAGTTCGGTCGGTGTCTCGAAACTTGGAACAATTGGTGGAAGAGTTGCCAGTGTTTTTGCTCCGTCTCGAAGAAGTCACGATAGCCATGGACGACAGGCTACAGTGGAGAGAGTTCAAATTCTGTTTCAAAGTAGCGACGAGCAAAGTCTCTGGGATATTGTCAAAACTTATTTTGCACCGAGAAACGCTGCAAGATGTTATTGTAAGATTTTGCTCACTGGTGCAAGGGAAAGCGTTCACATTGGGCTTGCTCGAATTGGGAATTCTCCATTCGACAGTCCAAGTGATGGGAACGTCTGCAATGGGCACCGCACACCATGCCGATCAATACAAAGACTCCACACAGCAGAAGAGAGAGCATCCTGCCCAACATGGATTTAAGCTCAGCCTGGTTGAGTCCCTTATGAAGCCACCTCCGGTGAATCAAAGCTGTCTATCGAAAGCTGCAGCAAAGCTATTGAAATCAGAAAGATTCGCCGATATGGTGTTTGAGATTCCGATGCCACAACCAGCTCAATCGGCACCTAATAGTAATTCTAAGCATATCACGGATGTTAATCTGGCATCATTACCTGCTAAAGACATCAAAGCTGCCAACGAAGCGTCTTCGTCTGACAGTACGCACAACACGCCTTCGCGAATGGAAAATGTTCACATAGAGGACAATGGAAGTATTGTGATGAAAGCTCACAGAGTTATTGTGGCGGCGAGGTGCGACTGGTTTAGGCGAGCCTTACAATCCGGAATGAAGGAAGCGATTCACAGGAGAATTGTTATTCACGACACAACTCCAGGGATTTTTAGAAAACTGCTAACATATCTTTACACTGGAAAACTTGATACAAGAGTTGCCAACGCTGAACATCTCACTGAACTGGTTTTGCTCGGCGATCGATACGAACTGGACTCGTTAAAGAACGCTTGCGAGAAAACATTAGCCGTAAAGTACTTGGATAAAGACAGCGTCTTTTACTACTTGAGCTTGGCAGACCAGTACAATGCATCATATCTCAGGGAATCGTGTGTGAAATTCATCGCAACTCGGGCAAACATGATGAAAGGAGACCTCTTCGCGGAATTGCCTCCGTCTCTTCAACAGGAAGTTTATGCTGCTGTTGCTATGTGGCCTTTAGATATCGGTATCAGTGGAAGACGAAGACGTCATTACAGCCATGTCGGCGCCAGTGCGGATCATCTCAGCATGGAGGCTCTGTTAGACCGTGCGAGCCTTGATGATGAGGGATCCAACTCAGAGTGCAGCAGTGTTGAAGAAATAGAGATAGACAGAGGCCGTTTGAACGATTGCCTCGCAAGACTGCGAGCGATGCTCGGCCCGAGAGTGCCTCTAGATGACCTCAACCGAATAGCATTGGCCGCCGATTGCGATGCCAATAGGGCTGTCAACTTTTACTACTCCTCTTCGATGAGTCCACCGGATGATTCATGA
Protein Sequence
MAAYSFIGTWEIETCWIQGNYGVDSELEGTKFVLDDTGDVTWCPENEETSNIPLFSCETYEIYSTNIHGAIVRFGAYGEHIIEFRAEPSQPVDNLVLSCEGWCVLHCVRVTNDEPDCNPIEGFSLLPAVEDGFFSDMVIEAQDNKQFHVHSSILGLLGTDMSWMRDPPPFSGLPEGVVGSILHWLYAECLPNAMTEDLAMQVIDAVKEYPCMLKLVDDCKVYLKNMALKQQIVELVSDMHTSANQIIEYFNTPGECLGCHPAKLCLVVKQSVRETAVAVAKLLLLCELFSKRKNELSREERHEVIRYARSRLPIFMCQLRKLLESLKITFSSMTPAQRQEVATYLVPEIEAILDTISALIFEVKTALELIMQALTPAEGTDKCDPSVSGKATRDALGKSLRNVLRIRELAKLKNFHQKVTFSLMHLLHKKESFAEMSDSNRVRSVSRNLEQLVEELPVFLLRLEEVTIAMDDRLQWREFKFCFKVATSKVSGILSKLILHRETLQDVIVRFCSLVQGKAFTLGLLELGILHSTVQVMGTSAMGTAHHADQYKDSTQQKREHPAQHGFKLSLVESLMKPPPVNQSCLSKAAAKLLKSERFADMVFEIPMPQPAQSAPNSNSKHITDVNLASLPAKDIKAANEASSSDSTHNTPSRMENVHIEDNGSIVMKAHRVIVAARCDWFRRALQSGMKEAIHRRIVIHDTTPGIFRKLLTYLYTGKLDTRVANAEHLTELVLLGDRYELDSLKNACEKTLAVKYLDKDSVFYYLSLADQYNASYLRESCVKFIATRANMMKGDLFAELPPSLQQEVYAAVAMWPLDIGISGRRRRHYSHVGASADHLSMEALLDRASLDDEGSNSECSSVEEIEIDRGRLNDCLARLRAMLGPRVPLDDLNRIALAADCDANRAVNFYYSSSMSPPDDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00800305;
90% Identity
iTF_00800305;
80% Identity
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