Basic Information

Gene Symbol
-
Assembly
GCA_031772345.1
Location
CM062844.1:23264829-23280037[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 1.3e-05 0.00061 20.4 1.4 1 23 176 199 176 199 0.97
2 12 5.1e-06 0.00024 21.6 0.2 1 23 331 353 331 353 0.98
3 12 3.1e-06 0.00015 22.3 4.4 1 23 360 382 360 382 0.96
4 12 4.6e-06 0.00022 21.8 4.3 1 20 388 407 388 410 0.93
5 12 6.9e-06 0.00033 21.2 1.4 1 21 416 436 416 439 0.90
6 12 0.0011 0.053 14.3 0.7 3 23 451 471 450 471 0.97
7 12 6.8e-05 0.0032 18.1 3.3 1 23 476 498 476 498 0.96
8 12 1.3e-06 6.4e-05 23.4 0.5 1 23 504 526 504 526 0.96
9 12 7.8e-05 0.0037 17.9 0.7 1 23 532 554 532 554 0.98
10 12 1.1e-06 5.1e-05 23.7 1.6 3 23 562 582 560 582 0.96
11 12 5.9e-06 0.00028 21.4 0.6 1 23 588 610 588 610 0.99
12 12 0.0075 0.36 11.6 0.8 1 23 615 638 615 638 0.97

Sequence Information

Coding Sequence
atGGCACATGAAGTAATTCGCTTGGACCGCGTGTGCCGTGGTTGTCTTAGGGAAGACGGAGAGATGAAATCCTTATTTACAATCGGCGAAGGCCTCGGACAGGACAAACGGCGACTTGACCAAATGCTCATCTCGAGCACTCAAATCCagGTAACAGAAAATGATGGACTTCCATGCCAGATTTGTGAATTGTGTACACACCAGCTATATTCAGCCTACTCTTTTAAACACATGTGTGAGCGTTCTGATGCTAATCTCAAAAGATATGTTTCAAAAACACATCAGAATCCAGTAGCTCCTGGTGCTTGCCACCAAGCTGGGAGTGGGACAGgagtTAAGCAGGAAACATCTTTACCTACTATATCCGGaagtagtgaaattattgattttaatactaTGATCAATGCTGACTTACCAATTATCAAGGTGGAAGCTAGAGACCATTTGGGTTATGAACACGAGCATAAGGCAGTTGTCAGatataataattatgagaaACATCAGTTACAATGTGAAGGAAAGTCCTATGCATGTACAATTTGTGACAAGACATTTAGAAAACATGATTCACTTATAATCCATAGCAAAACAGCACATGGGAAAAAAGAAgATCCTGATGATTACACGAATAATGGTGAGCCAATTACCGTTGAAGTACCACCGAAGAGccatatttcaaagaaaaacagCTCATTGCACAAAAGTTATGAACCATTATTGGGACCAAGTTTAGATCTGTTAAATCCGgaagttaatataaaacaagaaCCCTTAGAAGAATTATTAGAAGAAGCAGAAAGagaAATACAAGGCATGAATGATGATGATGATAGCTTCGCCGATGCCTTTGCTGATCATAACAGTCCGCCCAGTATAGACgagaatgatTATCAATCAGACAATTCTGGTACAAAGCCTCTGCTTAGTTTGAAACGAAAAGTGGGTAGACCACGGAAAAAACCACTCCTCGACGATTCCATGGGAGAAAAATATCCATGCAATATGTGTCCTAAAGTATTTTCTTCTAATATTGGCCTAAAAATACATCAGTCAAAGCACACTGGAGAAACAATACTACACACTTGTTCAGTTTGTGGAAAATCATTCAATAGATCGAATCATCTTAAGCGTCATGAACTGATACATGGTTCAATCAAAAGACACAAATGTGACACATGCGGAAAATCCTTTAATAGACAAGACCATCTGAAGAAACACTTATGGATGCATTTGGAAACTAAACCTCACCAGTGTGAAATATGTAACAAAGGATTCTCTAGAGCTGAACATCTCAATCGACATAAAGTTGCTGTGCATTCAGGAAAAGAGAAGAATCCCAAGACAGCTTTTTGTTTGATATGCAATAGAGgTTTTACAACTGTTAAATACTTGGACACACACATGCAGATGCACACCGATAAAACATTCTCATGTAAACTCTGTGATAAAACATTTGATTCTAAATGGCATTTGAAAGAACACAGCAAATGGCACTCGAATGAGAAGCCATTTTTGTGTTCTGAGTGCGGTCAGAGGTTTATTCGAAATGATTATCTTATCATACACATGCGTAGACATAAAGGAGAAAAACCATTCAAGTGCAGATTTTGTGGCAAAGGTTTCCCGAGAGTAACTGACCTTAACGTCCATGAAAGATATCACACAGGAGAAAAAACTCATCTTTGCACAATTTGTGGGAAAGGCTTCCAGCGAcagtataatttgaaagtacATCTTAGAGTTCACACAGGAGAGAAACCGTATGTTTGTTCATTCTGTGGGAAGACATTCGCACAAGGAAATGATCTAAAATCGCATGTTCGCCGCCACACAGGAGAAAGATTCAACTGCGAAGTTTGCGGAGAAGGTTTCTTGCAAGGATATCATTTAACCCAACACAAGCGAAGTGTACACGGCCTTGAATGTTCATCTCACATACGAAGAGTGGAAAAACATCTTCAGCCAAATCCAGACATCAAGCCACATGTAGTTACCAAACGAAGAAGTCGTGGAGCAAATCAAAACCTTCTCGTTGCTCAGATGAATCAGATAAAGTTAGCGAATGAACTCCAGGTATAA
Protein Sequence
MAHEVIRLDRVCRGCLREDGEMKSLFTIGEGLGQDKRRLDQMLISSTQIQVTENDGLPCQICELCTHQLYSAYSFKHMCERSDANLKRYVSKTHQNPVAPGACHQAGSGTGVKQETSLPTISGSSEIIDFNTMINADLPIIKVEARDHLGYEHEHKAVVRYNNYEKHQLQCEGKSYACTICDKTFRKHDSLIIHSKTAHGKKEDPDDYTNNGEPITVEVPPKSHISKKNSSLHKSYEPLLGPSLDLLNPEVNIKQEPLEELLEEAEREIQGMNDDDDSFADAFADHNSPPSIDENDYQSDNSGTKPLLSLKRKVGRPRKKPLLDDSMGEKYPCNMCPKVFSSNIGLKIHQSKHTGETILHTCSVCGKSFNRSNHLKRHELIHGSIKRHKCDTCGKSFNRQDHLKKHLWMHLETKPHQCEICNKGFSRAEHLNRHKVAVHSGKEKNPKTAFCLICNRGFTTVKYLDTHMQMHTDKTFSCKLCDKTFDSKWHLKEHSKWHSNEKPFLCSECGQRFIRNDYLIIHMRRHKGEKPFKCRFCGKGFPRVTDLNVHERYHTGEKTHLCTICGKGFQRQYNLKVHLRVHTGEKPYVCSFCGKTFAQGNDLKSHVRRHTGERFNCEVCGEGFLQGYHLTQHKRSVHGLECSSHIRRVEKHLQPNPDIKPHVVTKRRSRGANQNLLVAQMNQIKLANELQV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00801129; iTF_00800353;
90% Identity
iTF_00801129; iTF_00800353;
80% Identity
-