Hami010806.1
Basic Information
- Insect
- Heteropelma amictum
- Gene Symbol
- -
- Assembly
- GCA_959613375.1
- Location
- OY390724.1:14478447-14481677[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 0.00038 0.74 9.8 0.0 21 92 13 83 7 95 0.86 2 4 0.59 1.1e+03 -0.5 0.0 25 50 342 367 333 374 0.84 3 4 0.00078 1.5 8.8 0.0 21 92 413 483 401 502 0.88 4 4 2.1 4.1e+03 -2.2 0.0 22 36 571 585 542 589 0.69
Sequence Information
- Coding Sequence
- ATGGGCAAAACTCGAGGAGTGCACGAGACTACGCCGGAATTGCGAAACCGGATGGTCGGCATGTACGAAGCAGGTTTGGGACTTCGCGATATCGCGGTGGCTGTCAATTGTTCGCAACGTACCGTAAAACGCTGGCTGAACAGATTCGACAAGGAAGGTACGGTGGAGACGAGGGAGCGATGCGGGCGAAAAAGAGCAACGACTGCGGAAGAGGATGACGCTATAATACGTCTTGCGACGCAAACTCCGATAACAGCGGCAAAAGCCGTGCTTCCTGCTCTCGGACTGAGGTGTTCGGTGGATACGATAAGAGAGAGACTGCACAAAGCTGGAATACACAATTGGAGTCCTTCGAGGAAGCACATGCAGAGGCTGCCTCTCGGCGACGAAGATGATGCGGCGGTTCAGCAGGCCGTATGGAGGCCGACCGGGACGCAGCTCGGGAAGAAAAAGCTCGTCGCGAAAGACAGCGGCGTCAAAAGCAAAAAGAATGGTGCATCCagtgggagaaagaaaaatcattcgtcaaAGATTCGAACTCGAAACGTTTACGGCGAAGATAGTGCGCCAGGCGTCGGTAACAAAGAGCCCGCCGGTTCCGgcgaattttctttcgaaccACAAAACGTCACGCAACAAGAAATTACGACGAATTTGGGGCAAGAAAATAACGACATGAGACTCGCGGACCAAACATTATCCGACAACCAGACGGTATTCGGCGGTGCTCTTAGTCTGGCACAACCGTTGCAACCACAGATTTATCAGCCTCACGCTGATTTGAACGTCGCTCAGAATTGGCCTCTTGATTTGGTTCAGGGAAGCCATCATTATCCTCAGGGCCAACCACATTCCTTGACTCACGAGCAACCTCCGCCGCAGCAGCAATTGCAAGAATTGCACACCCCGCGAGAACAGGAGCGTCGCAttcagcagcagcaacaacaaatGCAATCTCATCATCGAAACATGAAAGAGCAACGATCCGAGCGAGTACCTGTGGAGCGTGGGGTCGACGATGAGAATATTTCTGAAATTTCATCGGCGAACAAGCGACCCGGTAAGATATCGCGTACGGACAGTTGCTCGAATTCGAGCAGTTCGAACGATCGGGTGTCCGACATTGACGAGCTGAGCAGGgacgaatcgaaaaacgacgaggaagaTTTTGACGATAGtcggaaaaagggaaaaaagaagggtGGCAAGGCTAAAGGAACATTGGAGACGAGCGTCGAAATAAGAAATCGCATGATCGGCATGTCAGAAGCTGGCTTATCGACGTTATCGATCGCTCTGGCGATCAATAGATCCGAGAGGACCGTCAAAAGATGGCTCGAACGCTGGAACAAGGAAGGAAACGTACAgacgaaggagagaaaaggTCGTAAAAGAATAACAACGAAGGAACAGGATGATGCCATTATCGCTATGGCGACGCAGCATCCTTTGACAGCTGCCAAACATGTCGCCCCGGCGCTTGGACTCAATTGCAGCGTTGACACTATACGCGAGCGATTGCACAAAGCGGGAATCCACAGCTGGAAACTCGGTAAAAAACAAGGCGAAGGTAATGCGGTTCATACTGTACACCTTTGGCAGCCGAGTGGCAATAGGCCGAACAAGCCGAAGCTCTCCaacgaaaagaggaaaaaatcatcggaaaaaaaacgcgtaaCGTCGTCGAACGTACCGTCAAAACGAtcgttgagaagaaaaaagatcgtcgaaagtgcggaggaaaaaattgttccgCAAACTACGGCGATTATGGAAGCCCCACCCATGCAGTTTCAGGACAGCGGGCCGTTGACGGGTTACGTTTCAGGCTCGGAGATGCTGCAGCCTGTTCACAATTTATCAGGACCTACGATAGTACCTTCGCCGTCTGTGCCGCAAATTTCATCATCCATTACGCAGAGTATGCAAGTTATGGGACCGATGATGCAGCAGAGATCGGATTGTCGTATGGCAAATTCAGTCGTAACATCCGATCATCCGAATCCATCGGTTGTTTATCCCTCGTGCATGATCAGCAATAATCATTCGAGTCACATGGAACAACCGGATCCATTGAATTACGAGCCCTACATCTGGAgcttctga
- Protein Sequence
- MGKTRGVHETTPELRNRMVGMYEAGLGLRDIAVAVNCSQRTVKRWLNRFDKEGTVETRERCGRKRATTAEEDDAIIRLATQTPITAAKAVLPALGLRCSVDTIRERLHKAGIHNWSPSRKHMQRLPLGDEDDAAVQQAVWRPTGTQLGKKKLVAKDSGVKSKKNGASSGRKKNHSSKIRTRNVYGEDSAPGVGNKEPAGSGEFSFEPQNVTQQEITTNLGQENNDMRLADQTLSDNQTVFGGALSLAQPLQPQIYQPHADLNVAQNWPLDLVQGSHHYPQGQPHSLTHEQPPPQQQLQELHTPREQERRIQQQQQQMQSHHRNMKEQRSERVPVERGVDDENISEISSANKRPGKISRTDSCSNSSSSNDRVSDIDELSRDESKNDEEDFDDSRKKGKKKGGKAKGTLETSVEIRNRMIGMSEAGLSTLSIALAINRSERTVKRWLERWNKEGNVQTKERKGRKRITTKEQDDAIIAMATQHPLTAAKHVAPALGLNCSVDTIRERLHKAGIHSWKLGKKQGEGNAVHTVHLWQPSGNRPNKPKLSNEKRKKSSEKKRVTSSNVPSKRSLRRKKIVESAEEKIVPQTTAIMEAPPMQFQDSGPLTGYVSGSEMLQPVHNLSGPTIVPSPSVPQISSSITQSMQVMGPMMQQRSDCRMANSVVTSDHPNPSVVYPSCMISNNHSSHMEQPDPLNYEPYIWSF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -