Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 0.29 7.5e+03 -3.6 0.2 263 280 82 99 40 103 0.51

2 2 2e-66 5.1e-62 210.4 15.2 1 222 118 333 118 334 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	0.29	7.5e+03	-3.6	0.2	263	280	82	99	40	103	0.51
2	2	2e-66	5.1e-62	210.4	15.2	1	222	118	333	118	334	0.93

Coding Sequence: ATGGGCGAGCGATCTGATCAAGCGACTCCTGAGAACAGTGACGAAGAAAGCGGAGACGCCTTCACTGATGGAGATTTCGGTGATTCGGACGATGAAACTGTTATCGAACGTACTAGTAAAAAGATATCTTTAAATGAAACTCTGAATGCTGCTGTGAAACTTGATGATAATGTCGTTGATGAGATTCATAATGGTCATAAAGAAACCCTTAGTGGTGCCGATAATGACGATATAGACAATACTATAAGTAGTCAGAACAATGGTGATAATTCATTGGATGATATGAGCAGAGATTCGCAGAGCGACAGCAATGGATGTATCGTTGGAATTCTGGGAGATCAACAAAGTCACGCGGAACAGCGGCTAGCTGCTCGGCGAGCGGCGCGGGCGGAGGCGCGCGAGATCCGCATGAGGGAACTCGAACGACAGCAGCGCGAACAGGAGGACCATGCTGACAAGGCGTATGATATGTATGCAGAAACAGTGGGTCGACGGGCGGGCGGTCGGTTGGCGGCGATGAGTCCCAGCGCGCTGCACTCGCCGAGACGAAGCTCCGAAGACTCGGACGATGTGCTGAGCATCAAGGACCTTAGGCACGAGCTGAAGGAGGTCGAGGAGAAGTTCCGCAAGGCGATGATCCTGAACGCTCAGCTCGACAACGACAAGGCGGCGCTCGGGTACCAGCTCGAGCTGCTCAAGGACAGGATAGAGGAGCTGCAGGAGGAGTACGCGCAGCTGCAGCGTGAACATAGAGAGAAGTGCTCGAGCCACGAGCGCTTAAAGCGGGACCACGCGTCGCTGGAGCGCGAGGTGACGCTCGCGCGGGACGCGGTGCGCGCGCGGGACGCGGCGGCGGCGGCCGCGGGACGCGCCTTCGTGGAGGCGGCGAGCGCGCCCGACGCGCCCAGCGGGGAGCGCGCGGGCGCCGTCCCGCCGCTCGCGCTCGTCTCGCACGACTCGCAGCGGCTGCTCGACGACGCGGGCGAGGGTACACTAGGTAACTAA
Protein Sequence: MGERSDQATPENSDEESGDAFTDGDFGDSDDETVIERTSKKISLNETLNAAVKLDDNVVDEIHNGHKETLSGADNDDIDNTISSQNNGDNSLDDMSRDSQSDSNGCIVGILGDQQSHAEQRLAARRAARAEAREIRMRELERQQREQEDHADKAYDMYAETVGRRAGGRLAAMSPSALHSPRRSSEDSDDVLSIKDLRHELKEVEEKFRKAMILNAQLDNDKAALGYQLELLKDRIEELQEEYAQLQREHREKCSSHERLKRDHASLEREVTLARDAVRARDAAAAAAGRAFVEAASAPDAPSGERAGAVPPLALVSHDSQRLLDDAGEGTLGN

Sequence clustering based on sequence similarity using MMseqs2